科学研究
精准生物医用材料课题组
  本课题组主要围绕肿瘤的诊断及治疗这一热点科学问题,致力于设计开发具有精准序列结构的多维高分子生物材料,以及其在药物递送、基因治疗、蛋白免疫治疗、生物成像等多个领域中的应用。旨在建立一套普适的平台技术,用以构建精准有序的纳米递送体系,研究载体与生物体的作用机制,可控调节其性能,进而优化其临床疗效。目前,本课题组在高分子化学、材料科学、生物医药等多个领域积累了丰富的研究基础和研发经验,已累计发表SCI论文30余篇,包括Science、Nature、Nature Chem.、Adv. Mater.、Acc. Chem. Res.、Angew. Chem. Int. Ed.、Chem. Commun.、ACS Appl. Mater. Interfaces、Nanoscale、ACS Macro Lett.等,论文SCI总引超 2000次,多篇论文入选ESI高被引论文及年度阅读量最高论文,相关成果得到了国际学术同行的认可,并被科学杂志、PHYS.ORG、MIRAGE新闻网、国际化学工程师协会(IChemE)、ACS Noteworthy Chemistry及X-MOL等作为研究亮点报道。

课题组长:董瑞蛟

课题组成员

工作人员:于力

学生:博士:李紫莹、陈柏杨、黄琦婧

硕士:徐亚芩、袁子航、游璐嘉、陈玉(联培)

本科生:熊博、王一鸣、张舒畅、杨展宏、陈思霖

 

主要研究方向

1. 全自动流动化学合成技术构建精准有序生物医用高分子材料

2. 精准蛋白药物、非病毒基因递送载体的开发及其与生物体作用机制研究

3. 多维有序共轭高分子材料的可控制备及生物应用研究

 

课题组网站

http://www.donggroup.sjtu.edu.cn/Default.aspx

 

联系方式

Email: drj021@sjtu.edu.cn

 

代表性成果
1. Zhiwei Jiang†, Ruijiao Dong†, Austin M. Evans, Niklas Biere, Mahmood A. Ebrahim, Siyao Li, Dario Anselmetti, William R. Dichtel, Andrew G. Livingston*. Aligned macrocycle pores in ultrathin films for accurate molecular sieving. Nature 2022, 609, 58–64. († Co-first Author) Highlighted by ScienceMag, MirageNews, Phys.org and X-MOL
2. Siyao Li, Ruijiao Dong, Valentina-Elena Musteata, Jihoon Kim, Neel D. Rangnekar, J. R. Johnson, Bennett D. Marshall, Stefan Chisca, Jia Xu, Scott Hoy, Benjamin A. McCool, Suzana P. Nunes, Zhiwei Jiang*, Andrew G. Livingston*. Hydrophobic polyamide nanofilms provide rapid transport for crude oil separation. Science 2022, In press.
3. Weiping Wu*, Xiaolei Fan*, Yongliang Li*, Ruijiao Dong*. Growing collaborations between Chinese and UK young scholars on chemical science and technology. Front. Chem. Sci. Eng. 2021, 15, 1–3. Editorial, Guest Editor
4. Wumaier Yasena, Ruijiao Dong*, Aliya Aini, Xinyuan Zhu*. Recent advances on supramolecular block copolymers for biomedical applications. Journal of Materials Chemistry B, 2020, 8, 8219–8231. (Corresponding author)
5. Ruijiao Dong, Ruiyi Liu, Piers R. J. Gaffney, Marc Schaepertoens, Patrizia Marchetti, Christopher M. Williams, Rongjun Chen, Andrew G. Livingston*. Sequence-defined multifunctional polyethers via liquid-phase synthesis with molecular sieving. Nature Chemistry 2019, 11, 136–145. Highlighted by IChemE; Highlighted by X-MOL; Imperial College News
6. Wumaier Yasen, Ruijiao Dong*, Linzhu Zhou, Yu Huang, Dongbo Guo, Dong Chen, Chuanlong Li, Aliya Aini, Xinyuan Zhu*. Supramolecular block copolymer for gene delivery: Enhancement of transfection efficacy by charge regulation. Chemical Communications 2017, 53, 12782−12785. (Corresponding author)
7. Wumaier Yasen, Ruijiao Dong*, Linzhu Zhou, Jieli Wu, Chengxi Cao, Aliya Aini, Xinyuan Zhu*. Synthesis of a cationic supramolecular block copolymer with covalent and noncovalent polymer blocks for gene delivery. ACS Applied Materials & Interfaces 2017, 9, 9006−9014. (Corresponding author)
8. Ruijiao Dong, Screenath P. Ravinathan, Lizhe Xue, Nan Li*, Yingjian Zhang, Linzhu Zhou, Chengxi Cao, Xinyuan Zhu*. Dual-responsive aggregation-induced emission-active supramolecular nanoparticles for gene delivery and bioimaging. Chemical Communications 2016, 52, 7950–7953.
9. Ruijiao Dong, Yongfeng Zhou, Xiaohua Huang, Xinyuan Zhu*, Yunfeng Lu, Jian Shen*. Functional supramolecular polymers for biomedical applications. Advanced Materials 2015, 27, 498–526. ESI Highly Cited Paper; One of the Most-Read Articles
10. Ruijiao Dong, Yan Pang, Yue Su, Xinyuan Zhu*. Supramolecular hydrogels: Synthesis, properties and their biomedical applications. Biomaterials Science 2015, 3(7), 937–954. 2015's most accessed Biomaterials Science articles
11. Ruijiao Dong, Yongfeng Zhou, Xinyuan Zhu*. Supramolecular dendritic polymers: From synthesis to applications. Accounts of Chemical Research 2014, 47, 2006–2016. One of the Most-Read Articles
12. Ruijiao Dong, Yang Bo, Gangsheng Tong, Yongfeng Zhou, Xinyuan Zhu*, Yunfeng Lu*. Self-assembly and optical properties of a porphyrin-based amphiphile. Nanoscale 2014, 6, 4544–4550.
13. Ruijiao Dong, Yue Su*, Songrui Yu, Yongfeng Zhou, Yunfeng Lu*, Xinyuan Zhu*. A redox-responsive cationic supramolecular polymer constructed from small molecules as a promising gene vector. Chemical Communications 2013, 49, 9845–9847.
14. Ruijiao Dong, Bangshang Zhu, Yongfeng Zhou*, Deyue Yan, Xinyuan Zhu*. Reversible photoisomerization of azobenzene-containing polymeric systems driven by visible light. Polymer Chemistry 2013, 4, 912–915. One of the Most-Read Articles
15. Ruijiao Dong, Bangshang Zhu, Yongfeng Zhou*, Deyue Yan, Xinyuan Zhu*. "Breathing" vesicles with jellyfish-like on–off switchable fluorescence behavior. Angewandte Chemie-International Edition 2012, 51, 11633–11637. Highlighted by ACS “Noteworthy Chemistry”
16. Ruijiao Dong, Hongying Chen, Dali Wang, Yuanyuan Zhuang, Lijuan Zhu, Yue Su, Deyue Yan, Xinyuan Zhu*. Supramolecular fluorescent nanoparticles for targeted cancer imaging. ACS Macro Letters 2012, 1, 1208–1211. One of the Most-Read Articles
17. Ruijiao Dong, Linzhu Zhou, Jieli Wu, Chunlai Tu, Yue Su, Bangshang Zhu, Hongchen Gu, Deyue Yan, Xinyuan Zhu*. A supramolecular approach to the preparation of charge-tunable dendritic polycations for efficient gene delivery. Chemical Communications 2011, 47, 5473–5475.
18. Ruijiao Dong, Yong Liu, Yongfeng Zhou*, Deyue Yan, Xinyuan Zhu*. Photo-reversible supramolecular hyperbranched polymer based on host–guest interactions. Polymer Chemistry 2011, 2, 2771–2774.
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