董瑞蛟-上海交通大学系统生物医学研究院

学习经历
2009–2014 上海交通大学化学化工学院理学博士
2006–2009 东华大学材料科学与工程学院理学硕士
2002–2006 武汉纺织大学材料科学与工程学院工学学士

工作经历
2020年11月至今上海交通大学系统生物医学研究院特别研究员（博士生导师）
2015年6月–2020年10月英国帝国理工学院化工系博士后
2014年9月–2015年5月上海交通大学生命科学技术学院博士后

人才奖项
2021年国家优秀青年科学基金（海外）
2021年上海海外高层次人才计划
2023年浙江丽水市“绿谷精英·创新引领行动”计划
2022年江苏省“333高层次人才培养工程”计划
2021年江苏省泰州市高层次创新创业人才引进计划
2020年上海交通大学人才引进计划
2019年英国帝国理工学院Sir William Wakeham奖
2019年欧洲生物材料大会优秀学术报告奖
2017年国际化工协会年会优秀学术报告奖
2014年上海交通大学优秀毕业生
2012年教育部博士研究生学术新人奖
2012年教育部博士研究生国家奖学金

学会兼职与审稿人
1. 担任国际学术期刊《Nano-Micro Letters》(IF = 26.6) 青年编委
2. 担任国际学术期刊《Environmental Science & Ecotechnology》(IF = 12.6) 青年编委
3. 担任国际学术期刊《Frontiers of Chemical Science and Engineering》（IF = 4.5）客座编辑（Materials, Energy and Environment特刊, 2020)
4. 担任国际学术期刊《Molecules》（IF = 4.6）客座编辑
5. 担任国际期刊《Frontiers in Chemistry》（IF = 5.5）客座编辑
6. 美国化学会（ACS）会员、英国皇家化学会（RSC）会员、国际化工协会（SCI）会员兼学术大使、中国化学会（CCS）会员
7. 担任PNAS、Nano-Micro Letters、ACS Macro Letters、Macromolecules、Langmuir、Scientific Reports、Polymer Chemistry、Chemistry-A European Journal等国际学术期刊审稿人

主要围绕肿瘤的诊断及治疗这一热点科学问题，致力于设计开发具有精准序列结构的多维高分子生物材料，以及其在药物递送、基因治疗、蛋白免疫治疗、生物成像等多个领域中的应用。旨在建立一套普适的平台技术，用以构建精准有序的纳米递送体系，研究载体与生物体的作用机制，可控调节其性能，进而优化其临床疗效。具体研究方向包括：
1. 全自动流动化学合成技术构建精准有序生物医用高分子材料
2. 精准蛋白药物、非病毒基因递送载体的开发及其与生物体作用机制研究
3. 多维有序共轭高分子材料的可控制备及生物应用研究

Since SJTU
8. Yu Chen, Kaiyuan Song, Ziying Li, Yue Su, Baiyang Chen, Qijing Huang, Li Yu, Zeguang Han, Yongfeng Zhou, Xinyuan Zhu, Lintai Da, Jia Xu* and Ruijiao Dong*. Angewandte Chemie 2024, Under revision. (* Corresponding author) (IF = 16.6)
7. Li Yu†*, Baiyang Chen†, Ziying Li†, Yue Su, Xuesong Jiang, Zeguang Han, Yongfeng Zhou, Deyue Yan, Xinyuan Zhu and Ruijiao Dong*. Computer-aided automated flow chemical synthesis of polymers. Giant 2024, DOI: 10.1016/j.giant.2024.100252. (Invited review) (* Corresponding author) (IF = 6.9)
6. Ziying Li, Kaiyuan Song, Yu Chen, Lujia You, Li Yu, Baiyang Chen, Qijing Huang, Zihang Yuan, Yaqin Xu, Yue Su, Lintai Da,* Xinyuan Zhu, and Ruijiao Dong*. Nature Communications 2023, Under revision. (* Corresponding author) (IF = 16.6)
5. Li Yu†*, Baiyang Chen†, Ziying Li, Qijing Huang, Kaiyuan He, Yue Su,* Zeguang Han, Yongfeng Zhou, Xinyuan Zhu, Deyue Yan and Ruijiao Dong*. Digital synthetic polymers for information storage. Chemical Society Reviews 2023, 52, 1529–1548. (* Corresponding author) (IF = 60.615)
4. Wumaier Yasen*, Bei Li, Aliya Aini, Ziying Li, Yue Su, Linzhu Zhou*, Dongbo Guo, Qiuhui Qian, Dong Chen, Xinyuan Zhu, Ruijiao Dong*. Visible Light-Guided Gene Delivery with Nonviral Supramolecular Block Copolymer Vectors. ACS Applied Materials & Interfaces 2023, 15(35), 41817–41827. (* Corresponding author) (IF = 10.383)
3. Siyao Li, Ruijiao Dong, Valentina-Elena Musteata, Jihoon Kim, Neel D. Rangnekar, J. R. Johnson, Bennett D. Marshall, Stefan Chisca, Jia Xu, Scott Hoy, Benjamin A. McCool, Suzana P. Nunes, Zhiwei Jiang*, Andrew G. Livingston*. Hydrophobic polyamide nanofilms provide rapid transport for crude oil separation. Science 2022, 377, 1555–1561. Highlighted by ScienceDaily, NatureAsia, MirageNews and X-MOL (IF = 63.714)
2. Zhiwei Jiang†, Ruijiao Dong†, Austin M. Evans, Niklas Biere, Mahmood A. Ebrahim, Siyao Li, Dario Anselmetti, William R. Dichtel, Andrew G. Livingston*. Aligned macrocycle pores in ultrathin films for accurate molecular sieving. Nature 2022, 609, 58–64. († Co-first Author) Highlighted by ScienceMag, MirageNews, Phys.org and X-MOL (IF = 69.504)
1. Weiping Wu*, Xiaolei Fan*, Yongliang Li*, Ruijiao Dong*. Growing collaborations between Chinese and UK young scholars on chemical science and technology. Front. Chem. Sci. Eng. 2021, 15(1), 1–3. (Editorial, Guest Editor) (IF = 4.803)

Prior to SJTU
24. Ruijiao Dong, Ruiyi Liu, Piers R. J. Gaffney, Marc Schaepertoens, Patrizia Marchetti, Christopher M. Williams, Rongjun Chen, Andrew G. Livingston*. Sequence-defined multifunctional polyethers via liquid-phase synthesis with molecular sieving. Nature Chemistry 2019, 11, 136–145. Highlighted by IChemE; Highlighted by X-MOL; Imperial College News (IF = 24.274)
23. Ruijiao Dong, Yongfeng Zhou, Xiaohua Huang, Xinyuan Zhu*, Yunfeng Lu, Jian Shen*. Functional supramolecular polymers for biomedical applications. Advanced Materials 2015, 27, 498–526. ESI Highly Cited Paper; One of the Most-Read Articles (November, 2014) (IF = 32.086)
22. Ruijiao Dong, Yongfeng Zhou, Xinyuan Zhu*. Supramolecular dendritic polymers: From synthesis to applications. Accounts of Chemical Research 2014, 47, 2006–2016. One of the Most-Read Articles (May, 2014) (IF = 24.466)
21. Ruijiao Dong, Bangshang Zhu, Yongfeng Zhou*, Deyue Yan, Xinyuan Zhu*. "Breathing" vesicles with jellyfish-like on–off switchable fluorescence behavior. Angewandte Chemie-International Edition 2012, 51, 11633–11637. Highlighted by ACS “Noteworthy Chemistry” (IF = 16.823)
20. Wumaier Yasena, Ruijiao Dong*, Aliya Aini, Xinyuan Zhu*. Recent advances on supramolecular block copolymers for biomedical applications. Journal of Materials Chemistry B 2020, 8, 8219-8231. (* Corresponding author) (IF = 7.571)
19. Wumaier Yasen, Ruijiao Dong*, Linzhu Zhou, Yu Huang, Dongbo Guo, Dong Chen, Chuanlong Li, Aliya Aini, Xinyuan Zhu*. Supramolecular block copolymer for gene delivery: Enhancement of transfection efficacy by charge regulation. Chemical Communications 2017, 53, 12782−12785. (* Corresponding author) (IF = 6.222)
18. Wumaier Yasen, Ruijiao Dong*, Linzhu Zhou, Jieli Wu, Chengxi Cao, Aliya Aini, Xinyuan Zhu*. Synthesis of a cationic supramolecular block copolymer with covalent and noncovalent polymer blocks for gene delivery. ACS Applied Materials & Interfaces 2017, 9, 9006−9014. (* Corresponding author) (IF = 10.383)
17. Ruijiao Dong, Screenath P. Ravinathan, Lizhe Xue, Nan Li*, Yingjian Zhang, Linzhu Zhou, Chengxi Cao, Xinyuan Zhu*. Dual-responsive aggregation-induced emission-active supramolecular nanoparticles for gene delivery and bioimaging. Chemical Communications 2016, 52, 7950–7953. (IF = 6.222)
16. Ruijiao Dong, Yan Pang, Yue Su, Xinyuan Zhu*. Supramolecular hydrogels: Synthesis, properties and their biomedical applications. Biomaterials Science 2015, 3(7), 937–954. 2015's most accessed Biomaterials Science articles (IF = 7.59)
15. Ruijiao Dong, Yang Bo, Gangsheng Tong, Yongfeng Zhou, Xinyuan Zhu*, Yunfeng Lu*. Self-assembly and optical properties of a porphyrin-based amphiphile. Nanoscale 2014, 6, 4544–4550. (IF = 8.307)
14. Ruijiao Dong, Yue Su*, Songrui Yu, Yongfeng Zhou, Yunfeng Lu*, Xinyuan Zhu*. A redox-responsive cationic supramolecular polymer constructed from small molecules as a promising gene vector. Chemical Communications 2013, 49, 9845–9847. (IF = 6.222)
13. Ruijiao Dong, Bangshang Zhu, Yongfeng Zhou*, Deyue Yan, Xinyuan Zhu*. Reversible photoisomerization of azobenzene-containing polymeric systems driven by visible light. Polymer Chemistry 2013, 4, 912–915. One of the Most-Read Articles (January, 2013) (IF = 5.364)
12. Ruijiao Dong, Hongying Chen, Dali Wang, Yuanyuan Zhuang, Lijuan Zhu, Yue Su, Deyue Yan, Xinyuan Zhu*. Supramolecular fluorescent nanoparticles for targeted cancer imaging. ACS Macro Letters 2012, 1, 1208–1211. One of the Most-Read Articles (October, 2012) (IF = 7.015)
11. Ruijiao Dong, Linzhu Zhou, Jieli Wu, Chunlai Tu, Yue Su, Bangshang Zhu, Hongchen Gu, Deyue Yan, Xinyuan Zhu*. A supramolecular approach to the preparation of charge-tunable dendritic polycations for efficient gene delivery. Chemical Communications 2011, 47, 5473–5475. (IF = 6.222)
10. Ruijiao Dong, Yong Liu, Yongfeng Zhou*, Deyue Yan, Xinyuan Zhu*. Photo-reversible supramolecular hyperbranched polymer based on host–guest interactions. Polymer Chemistry 2011, 2, 2771–2774. (IF = 5.364)
9. Ruijiao Dong, Jiongxin Zhao*, Youwei Zhang, Ding Pan. Morphology control of polyacrylonitrile (PAN) fibers by phase separation technique. Journal of Polymer Science Part B: Polymer Physics 2009, 47, 261–275. (IF = 3.151)
8. Ruijiao Dong, Marcus Keuser, Xiaomei Zeng, Jiongxin Zhao*, Youwei Zhang, Chengxun Wu, Ding Pan. Viscometric measurement of the thermodynamics of PAN terpolymer/DMSO/water system and effect of fiber-forming conditions on the morphology of PAN precursor. Journal of Polymer Science Part B: Polymer Physics 2008, 46, 1997–2011. (IF = 3.151)
7. Songrui Yu, Ruijiao Dong, Jianxin Chen, Feng Chen, Wenfeng Jiang, Yongfeng Zhou*, Xinyuan Zhu*, Deyue Yan. Synthesis and self-assembly of amphiphilic aptamer-functionalised hyperbranched multiarm copolymers for targeted cancer imaging. Biomacromolecules 2014, 15, 1828–1836. (IF = 6.978)
6. Yu Huang, Ruijiao Dong, Xinyuan Zhu*, Deyue Yan*. Photo-responsive polymeric micelles. Soft Matter 2014, 10, 6121–6138. (IF = 4.046)
5. Xuan Wei, Ruijiao Dong, Dali Wang, Tianyu Zhao, Yongsheng Gao, Patrick Duffy, Xinyuan Zhu*, Wenxin Wang*. Supramolecular fluorescent nanoparticles constructed via multiple non-covalent interactions for the detection of hydrogen peroxide in cancer cells. Chemistry–A European Journal 2015, 21(32), 11427–11434. (IF = 5.236)
4. Xiuying Huan, Dali Wang, Ruijiao Dong, Chunlai Tu, Bangshang Zhu*, Deyue Yan, Xinyuan Zhu*. Supramolecular ABC miktoarm star terpolymer based on host-guest inclusion complexation. Macromolecules 2012, 45, 5941–5947. (IF = 6.057)
3. Songrui Yu, Jianxin Chen, Ruijiao Dong, Yue Su, Bing Ji, Yongfeng Zhou*, Xinyuan Zhu*, Deyue Yan. Enhanced gene transfection efficiency of PDMAEMA by incorporating hydrophobic hyperbranched polymer cores: effect of degree of branching. Polymer Chemistry 2012, 3, 3324–3329. (IF = 5.364)
2. Dali Wang, Gangsheng Tong*, Ruijiao Dong, Yongfeng Zhou, Jian Shen*, Xinyuan Zhu*. Self-assembly of supramolecularly engineered polymers and their biomedical applications. Chemical Communications 2014, 50, 11994–12017. (IF = 6.222)
1. Hongping Deng, Yue Su, Minxi Hu, Xin Jin*, Lin He, Yan Pang, Ruijiao Dong, Xinyuan Zhu*. Multicolor fluorescent polymers inspired from green fluorescent protein. Macromolecules 2015, 48, 5969–5979. (IF = 6.057)

主持国家优秀青年科学基金项目(海外)（2023-2025）、国家自然科学基金面上项目（2024-2027）、国家自然科学基金面上项目（2022-2025）、上海市自然科学基金面上项目（2022-2025）、国家自然科学基金青年基金（2016–2018年）、中国博士后面上基金（2016年）、上海芯像生物科技有限公司横向项目（2021年）、江苏省泰州市高层次创新创业人才项目（2022–2023年）、浙江丽水市“绿谷精英·创新引领行动计划”（2024–2026年）等。

参与英国物理科学研究委员会基金（EPSRC，2015–2017年）、欧洲研究委员会基金（ERC，2018–2023年）、国家杰出青年科学基金项目（2012-2014）、国家自然科学基金面上项目（2014–2017年）等。

成功申请PCT国际专利《Defined monomer sequence polymers》(WO2017042583A1)、以及PCT国际专利《Multi oligomer monomers in interfaciallly polymerised film》（GB2005106.6），以及中国发明专利《一种超支化聚乙二醇衍生物及其制备方法和应用》（202310058205.4）、《一种具有精准序列结构的蛋白质-高分子偶联物及其制备方法与应用》（202410220772.X）等。

课题组现有助理研究员1名、博士后1名、科研助理1名、博士生6名、硕士生8名、本科生4名。