功能代谢组学与创新中药研究课题组一直致力于基于生物质谱的功能代谢组学创新方法研究，微生物代谢研究和中药系统生物学研究。课题组建设与发展主体依托上海交通大学系统生物学研究院小分子质谱设施，建有国际一流水准的生物质谱平台、小分子代谢组功能表征平台和生物信息学平台，目前拥有UHPLC-QTOF和UHPLC-TQ联用系统2台套、多台套生物分子功能表征设施和生物信息学软件系统。近五年，课题组共承担国家重点研发计划课题，国家自然科学基金面上项目/青年项目和QUT Vice Chancellor’s Research Fellowships等10余项创新课题的研究工作，多篇论文发表于Mass Spectrometry Reviews, Journal of Proteome Research, Molecular Cellar Proteomics等领域内权威SCI检索杂志。课题组长吕海涛研究员目前兼任世中联网络药理学专委会常务理事，中国药理学会网络药理学专委会理事，中国药理学学会分析药理学专委会创会理事，美国科学促进会（AAAS）荣誉会员和国际代谢组学学会会员。同时担任SCI检索杂志Frontiers in Microbiology（IF 4.0）副主编， Frontiers in Pharmacology (IF 3.8) 副主编， Phytomedicine (IF 3.6)副主编，Scientific Reports (IF 4.1)和 Bioanalysis (IF 2.65)编委，以及SCI检索杂志Acta Pharmaceutica Sinica B （IF 6.0）和Chinese Journal of Natural Medicines (IF 1.9)青年编委，国家自然科学基金委和澳大利亚NHMRC基金评审专家。
代表性成果
1. Luo, X., Guo, R., Xu, X., Li, X., Yao, L., Wang, X., and Lu, H*. (2018) Spectrometry And Associated Technologies Delineate The Advantageously Biomedical Capacity Of SiderophoresIn Different Pathogenic Contexts. Mass Spectrometry Reviews, doi: 10.1002/mas.21577(Invited by Editor in Chief)(*Corresponding Author)
2. Su, Q., Guan, T. B., He, Y. and Lv, H*. (2016). Siderophore biosynthesis governs the virulence of uropathogenic Escherichia coli by coordinately modulating the differential metabolism. Journal of Proteome Research, 15, 1323–1332. (*Corresponding Author)
3. Su, Q, Xu, G. Guan, T. Que, Y. and Lu, H*. (2018). Mass spectrometry-derived systems biology technologies delineate the system’s applications of siderophores with chemistry and biology. Mass Spectrometry Reviews, 37, 188-201(Invited by Editor in Chief) (*Corresponding Author)
4. Lv, H. T*., Hung, C. S., and Henderson, J. P.* (2014): Metabolomic Analysis of Siderophore Cheater Mutants Reveals Metabolic Costs of Expression in Uropathogenic Escherichia coli. Journal of Proteome Research, 13, 1397-1404. (*Corresponding Author)
5. Yan, L. Y., Nie, W. N., and Lv, H. T. * (2015) Metabolic Phenotyping of the Yersinia High-Pathogenicity Island that Regulates Central Carbon Metabolism. Analyst, 140, 3356-3361. (*Corresponding Author)
