师资队伍

吕海涛

长聘教轨副教授、博导

 

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邮箱: haitao.lu@sjtu.edu.cn
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学习经历
2004年9月-2009年6月 黑龙江中医药大学 生药学(硕博连读) 博士学位
Ph.D., in Pharmacognosy, Heilongjiang University of Chinese Medicine
2000年9月-2004年7月 黑龙江中医药大学 中药学 学士学位
B.SC., in Pharmaceutical Sciences, Heilongjiang University of Chinese Medicine

 

工作经历
吕海涛博士,英国皇家化学会会士(FRSC),英国皇家生物学会会士(FRSB),上海交通大学特别研究员/课题组长/博士生导师,绿色通道引进高层次人才,QUT校长特聘教授席,澳门科技大学兼职教授/博导,交通大学功能代谢组科学实验室主任,上海院士专家工作站(专家级)首席专家。2009年于黑龙江中医药大学完成生药学博士学位(中医方证代谢组学方向),师从王喜军教授,2009-2013年在美国爱因斯坦医学院、华盛顿大学医学院和麻省理工学院完成博士后训练,合作导师Peter C. Dedon教授等。近五年,主持国家重点研发计划课题和国家自然科学基金等10余项课题。在Mass Spectrometry Reviews, Pharmacology & Therapeutics, Analytica Chimica Acta, Pharmacological Research, Molecular Cellar Proteomics等著名杂志发表SCI检索论文53篇,论文被Nature Chemical Biology, Nature Reviews Urology等著名杂志引用1500余次。近五年在国内外一流学术会议担任分会主席5次,大会邀请报告40余场次,被国外著名高校邀请报告6次。Faculty Member-Faculty Opinions (Faculty1000 Prime), 兼任中国生物物理学会代谢组学分会副秘书长;任Phytomedicine (Q1, TOP期刊)副主编, Pharmacological Research(Q1, TOP期刊)Section主编,ACS Pharmacology and Translational Science和Proteomics 编委,Acta Pharmaceutica Sinica B(Q1, TOP期刊)青年编委; 国家自然科学基金、澳大利亚NHMRC基金会和香港Health and Medical Research Fund (HMRF) 基金会评审专家; 澳门大学等著名高校Faculty Promotion评审专家。

2021年4月-至今 英国皇家化学会 会士 (FRSC)
Elected Fellow, The Royal Society of Chemistry in UK
2021年7月-至今 英国皇家生物学会 会士 (FRSB)
Elected Fellow, The Royal Society of Biology in UK
2016年9月-至今 上海交通大学系统生物医学研究院 研究员/PI/博士生导师
Professor, Principal Investigator, Faculty Director, PhD. Supervisor
Laboratory for Functional Metabolomics Science
Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
2020年8月-至今 澳门科技大学药学院 兼职教授/博士生导师
Adjunct Professor, PhD Supervisor
School of Pharmacy, Macau University of Science and Technology
2013年7月-2016年7月 QUT 校长特聘教授席 (国际人才基金,Adjunct Faculty)/博士生导师
QUT Vice Chancellor Research Fellow, PhD. Supervisor
2012年9月-2016年9月 重庆大学药学院(创新药物研究中心)百人计划研究员/博士生导师/主任助理
Professor, Assistant Dean, Principal Investigator, PhD. Supervisor
College of Pharmaceutical Sciences, Chongqing University
2009年9月-2013年1月 美国爱因斯坦医学院/华盛顿大学医学院/麻省理工学院 博士后研究员
Postdoctoral Fellow (Associate), Albert Einstein College of Medicine, Washington
University School of Medicine, MIT Smart Center/Dept. Biological Engineering

 

人才奖项
英国皇家化学会会士 (Elected Fellow of The Royal Society of Chemisty, FRSC)
英国皇家生物学会会士 (Elected Fellow of The Royal Society of Biology, FRSB)
Faculty Member, Faculty Opinions (Former F1000 Prime)
QUT校长特聘教授席(国际人才基金)
重庆大学百人计划(海外引进高层次人才)
上海交通大学特别研究员计划(绿色通道引进高层次人才)

 

学会兼职与审稿人
中国生物物理学会代谢组学分会 副秘书长
中国药理学会中药与天然药物药理学专委会(青委会)常务理事
中国药理学会网络药理学专委会 理事
中国药理学学会分析药理学专委会 理事
美国科学促进会(AAAS)荣誉会员
国际代谢组学学会 会员
上海交通大学系统生物医学研究院/国际合作与交流委员会 委员
上海交通大学系统生物医学研究院/研究生事务委员会 委员
澳门科技大学药学院 兼职教授/博导
西南医科大学中西医结合学院 客座教授
Phytomedicine (Elsevier) 副主编
Pharmacological Research (Elsevier) Section 主编
Frontiers in Microbiology 副主编
Proteomics (Wiley) 编委
ACS Pharmacology and Translational Science 编委
Acta Pharmaceutica Sinica B (Elsevier)青年编委
Journal of Analysis and Testing 青年编委
Chinese Journal of Natural Medicines 青年编委
《药学学报》青年编委
《色谱》杂志 青年编委

1. 精准修饰代谢组学/Precision-Modification Metabolomics
2. 微生物功能代谢组学/Microbial Functional Metabolomics
3. 中药系统药理学/Systems Pharmacology of Chinese Medicine
4. 生物质谱与分析化学/Biological Mass Spectrometry and Analytical Chemistry

代表性论文/Selected Publications
24. Dong, S., Zhu, M.,...Hu, L., Jing, W*., Lu, H*. and Wang, S., etc (2021). Dihydromyricetin improves DSS-induced colitis in mice via modulation of fecal-bacteria-related bile acid metabolism. Pharmacological Research, https://doi.org/10.1016/j.phrs.2021.105767. (*Corresponding Author)
23. Wang, T., Liu, J., Luo, X., Hu, L., and Lu, H*. (2021). Functional metabolomics innovates therapeutic discovery of traditional Chinese medicine derived functional compounds. Pharmacology & Therapeutics, https://doi.org/10.1016/j.pharmthera.2021.107824. (*Corresponding Author)
22. Guo, R., Luo, X., Liu, J., and Lu, H*. (2021). Mass spectrometry based targeted metabolomics precisely characterized new functional metabolites that regulate biofilm formation in Escherichia coli. Analytica Chimica Acta, https://doi.org/10.1016/j.aca.2020.12.021. (*Corresponding Author)
21. Jing, W., Luo, X., Liu, J., and Lu, H*., et al. (2021). Berberine improves colitis by triggering AhR activation by microbial tryptophan catabolites. Pharmacological Research., https://doi.org/10.1016/j.phrs.2020.105358. (*Corresponding Author)
20. Tian, T., Xu, X., Li, X., Zhang, W., and Lu, H*. (2020). Precision-characterization and quantitative determination of main compounds in Si-Ni-San with UHPLC-MS/MS based targeted-profiling method. Journal of Pharmaceutical and Biomedical Analysis, https://doi.org/10.1016/j.jpba.2020.113816. (*Corresponding Author).
19. Liu, J., Luo, X., Guo, R. and Lu, H*. (2020). Cell metabolomics reveals berberine inhibited cell viability and metastasis in pancreatic cancer cells by regulating citrate metabolism. Journal of Proteome Research, 19, 3825–3836. (*Corresponding Author)
18. Guo R., LU, H*. (2020). Targeted Metabolomics Revealed the Regulatory Role of Manganese On Small-Molecule Metabolism of Biofilm Formation in Escherichia Coli. Journal of Analysis and Testing, 4, 226–237. (*Corresponding Author)
17. Luo, X., Liu, J., Lu, H*., etc. (2020). Metabolomics identified new biomarkers for the precise diagnosis of pancreatic cancer and associated tissue metastasis. Pharmacological Research., https://doi.org/10.1016/ j.phrs. 2020.104805 (*Corresponding Author)
16. Guo, R., Luo, X., Xu, X., Lu, H*., etc. (2020) Microbial metabolomics: from methods to translational applications. Wiley, "Advances in Molecular Biology and Biochemistry", In Production.(*Corresponding Author)
15. Guo, R., Luo, X., Liu, J., Lu, H*., etc. (2020). Multi-omics strategies decipher therapeutic discovery of traditional Chinese medicine. Pharmacological Research, https://doi.org/10.1016 /j.phrs.2020.104627. (*Corresponding Author)
14. Hu, L., Liu, J., Zhang, W., Wang, T., H, Lu*., etc. (2020). Functional metabolomics decipher biochemical functions and associated mechanisms underlie small-molecule metabolism. Mass Spectrometry Reviews, https://doi.org/10.1002/mas.21611 (Invited by Editor in Chief) (*Corresponding Author)
13. Lu, H*. Que, Y., Wu, X., Guan, T. and Guo, H. (2019). Mass Spectrometry based Metabolomics Deciphered Metabolic Reprogramming That Was Required for Biofilm formation in Uropathogenic Escherichia coli. Scientific Reports, 9(1): 13160. (*Corresponding Author)
12. Xu, G., Guo, H., and Lv, H*. (2019). Metabolomics Assay Identified a Novel Virulence-Associated Siderophore Encoded by the High-Pathogenicity Island in Uropathogenic Escherichia coli (correction). J Proteome Res., 18, 2331-2336. (*Corresponding Author)
11. Luo, X., Guo, R., Xu, X., Li, X., Lu, H*., etc. (2019). Mass Spectrometry and Associated Technologies Delineate The Advantageously Biomedical Capacity Of Siderophores In Different Pathogenic Contexts. Mass Spectrometry Reviews, 38, 239-252 (*Corresponding Author)
10. Su, Q, Xu, G. Guan, T. Que, Y, and Lu, H*. (2018). Mass spectrometry-derived systems biology technologies delineate the system’s applications of siderophores with chemistry and biology. Mass Spectrometry Reviews, 37, 188-201 (*Corresponding Author)
9. Su, Q., Guan, T. B., He, Y. and Lv, H*. (2016). Siderophore biosynthesis governs the virulence of uropathogenic Escherichia coli by coordinately modulating the differential metabolism. Journal of Proteome Research, 15 , 1323–1332. (*Corresponding Author)
8. Su, Q., Guan, T. and Lv, H*. (2016) Siderophore biosynthesis coordinately modulated the virulence associated interactive metabolome of uropathogenic Escherichia coli and human urine. Scientific Reports, 6, 24099; doi: 10.1038/srep24099 (*Corresponding Author)
7. Nie, W.N., Yan, L. Y., Lu, H.T* ., etc.(2016). Advanced mass spectrometry based multiple omics technologies for exploring the pathogenesis of hepatocellular carcinoma. Mass Spectrometry Reviews, 35, 331-349. (*Corresponding Author)
6. Yan L, Nie W, Lu, H.T.*(2015)Metabolic phenotyping of the Yersinia high-pathogenicity island that regulates central carbon metabolism. Analyst. 2015;140(10):3356-3361.(*Corresponding Author)
5. Lv, H. T*., Hung, C. S., and Henderson, J. P.* (2014): Metabolomic Analysis of Siderophore Cheater Mutants Reveals Metabolic Costs of Expression in Uropathogenic Escherichia coli.Journal of Proteome Research, 13, 1397-1404. (*Corresponding Author)
4. Lv, H. T.* (2013): Mass spectrometry based metabolomics towards understanding of gene functions with a diversity of biological contexts, Mass Spectrometry Reviews, 32,118-128. (*Corresponding Author).
3. Lv, H.T., and Henderson, J. P*. (2011): YersiniaHigh Pathogenicity Island genes modify The Escherichia coli primary metabolome independently of siderophore production. Journal Proteome Research,10, 5547–5554.
2. Lv, H.T*., Hung, C. S., Chaturvedi, K. S., Hooton, T. M., and Henderson, J.P.* (2011):Development of an integrated metabolomic approach for Infectious Diseases Research. Analyst, 136, 4752-4763. (*Corresponding Author).
1. Lv, H.T.,Palacios, G., Hartil, K. and Kurland, I.J. (2011):Advantages of Tandem LC-MS for the Rapid Assessment of Tissue-specific Metabolic Complexity using a Pentafluorophenylpropyl Stationary Phase. Journal Proteome Research, 10, 2104-2012.

13. 上海市院士专家工作站(专家工作站);2021年度; 首席专家;在研
12. 上海“科技创新行动计划”自然基金项目 ; 执行期 2021-2024; 主持人;在研
11. 转化医学国家重大科技基础设施(上海) 2021年度开放课题(大科学计划预研项目); 执行期 2021-2023; 主持人;在研
10. Agilent Applications and Core Technology-University Research Fund (ACT-UR); 执行期 2021-2022; 主持人; 在研
9. 国家重点研发计划; 胰腺癌转移的阶段化代谢特征谱及代谢机理研究;执行期 2017/06-2021/12; 主持人;在研
8. 国家自然科学基金面上项目;致病性大肠杆菌中新铁载体的发现与功能表征;执行期 2017/01-2020/12;主持人;在研
7. 国家自然科学基金面上项目;基于代谢组学技术表征中药石韦治疗尿路感染的活性组分和作用机制;执行期 2013/01-2016/12; 主持人;结题
6. 重庆大学百人计划(海外引进高层次人才); 功能代谢组学与创新中药研究; 执行期 2012/07-2015/07; 获批经费:主持人;结题
5. 上海交通大学特别研究员计划(绿色通道引进高层次人才);精准修饰代谢组学;执行期 2015/12-2018/12;主持人;在研
4. 重庆自然基金面上项目;基于代谢组学技术表征中药人参治疗糖尿病的功能组分和作用机理;执行期2014/09-2017/09;主持人;结题
3. 中央高校基本科研业务费学校创新重大项目;新铁载体的发现与表征;执行期 2015/07-2017/07;主持人;结题
2. 中央高校基本科研业务费跨学科重大项目;基于代谢组学技术的人参治疗糖尿病的转化医学研究; 执行期 2014/06-2017/06;主持人;在研
1. QUT校长特聘教授席(国际人才基金);群体性肌肉损伤代谢生物标记物的发现与表征;执行期2013/07-2016/07; 主持人;结题

获批合作专利1项

已经毕业学生中2人在大学任教,3人在国家三级甲等医院,1人在海外攻读博士学位,10人任职于国内外著名质谱和生物医药公司。

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