本课题组长期致力于利用基因芯片和高通量测序技术及生物信息学手段，系统分析癌症基因组、转录组和甲基化组的变异，并探讨各种变异与临床特征的关联性，结合细胞学和动物学技术识别鉴定与肿瘤相关的重要功能基因，深入研究其在肿瘤发生发展中的分子机制，为肿瘤的临床诊断提供新的指标，或为最终治愈肿瘤提供潜在的药物靶点；致力于肿瘤转移复发的监测技术、肿瘤化疗药物用药指导的基因检测技术、白血病骨髓移植相关的HLA分型技术等的基因组临床应用技术转化研究；致力于女性肿瘤的防治措施研究和女性健康管理体系建设、产品开发与技术推广等相关女性移动健康管理体系研究。
课题组长：黄健
课题组成员
工作人员：邓宇亮 黄婉秋（博士后）
学生：博士：安艳 包超慧 韩颖鑫
硕士：仇林 安娜
主要研究方向
1. 肿瘤基因组变异的基础和应用研究
2. 肝癌发病机制研究及治疗药物研发
3. 宫颈癌筛查、早诊和预后技术研究
课题组公众号
代表性成果
1. Jian Huang#*, Zhaoyang Qian, Yuhua Gong, Yanzhou Wang3, Yanfang Guan, Yingxin Han, Xin Yi, Wanqiu Huang, Liyan Ji, Jiajia Xu, Mengyuan Su, Qing Yuan, Shujian Cui, Chaohui Bao, Weilong Liu, Xi Chen, Ming Zhang, Xiaohuan Gao, Renhua Wu, Yinxin Zhang, Huicheng Xu, Shida Zhu, Hongmei Zhu, Ling Yang, Xun Xu, Pingyu Zhou*, Zhiqing Liang*. Comprehensive genomic variation profiling of cervical intraepithelial neoplasia and cervical cancer identifies potential targets for cervical cancer early warning. Journal of Medical Genetics. 2018 Dec 19. pii: jmedgenet-2018-105745. doi: 10.1136/jmedgenet-2018-105745.
2. Xin Zou, Wei Cao, Jian Huang*, Jie Hao*, Ze-Guang Han*. Optimal Gene Filtering for Single-Cell data (OGFSC) – a gene filtering algorithm for single-cell RNA-seq data. Bioinformatics, 2018 Dec 10. doi: 10.1093/bioinformatics/bty1016.
3. Yingxin Han, Xing Liu, Yuqi Wang, Xiaolei Wu, Yanfang Guan, Xinchun Chen, Boping Zhou, Qing Yuan, Ying Ou, Renhua Wu, Wanqiu Huang, Yun wang, Ming Zhang, Yinxin Zhang, Dongxing Zhu, Hongmei Zhu, Ling Yang, Xin Yi, Chen Huang & Jian Huang*. Identification of characteristic TRB V usage in HBV-associated HCC by using differential expression profiling analysis. Oncoimmunology. 2015 Apr 2;4(8):e1021537. eCollection 2015.
4. Gao F, Xia Y, Wang J, Lin Z, Ou Y, Liu X, Liu W, Zhou B, Luo H, Zhou B, Wen B, Zhang X, Huang J*. Integrated analyses of DNA methylation and hydroxymethylation reveal tumor suppressive roles of ECM1, ATF5 and EOMES in human hepatocellular carcinoma. Genome Biol. 2015 Jan 3;15(12):533.
5. Huang J, Deng Q, Wang Q, Li KY, Dai JH, Li N, Zhu ZD, Zhou B, Liu XY, Liu RF, Fei QL, Chen H, Cai B, Zhou B, Xiao HS, Qin LX, Han ZG. Exome sequencing of hepatitis B virus-associated hepatocellular carcinoma. Nature Genetics. 2012 Aug 26;44(10):1117-1121.
