科学研究
2021年论文

1. Wang D, Shao X, Wang Q, Pan X, Dai Y, Yao S, Yin T, Wang Z, Zhu J, Xi X, Chen Z, Chen S, Zhang G. Activated factor X targeted stored in platelets as an effective gene therapy strategy for both hemophilia A and B. Clin Transl Med. 2021 Mar;11(3):e375. doi: 10.1002/ctm2.375. PMID: 33783994; PMCID: PMC7989710.

2. Yang Y, Chen T, Zhang X, Wang X. Age-related functional changes of intestinal flora in rats. FEMS Microbiol Lett. 2021 Jun 11;368(10):fnab051. doi: 10.1093/femsle/fnab051. PMID: 34003293.

3. Han Y, Ji L, Guan Y, Ma M, Li P, Xue Y, Zhang Y, Huang W, Gong Y, Jiang L, Wang X, Xie H, Zhou B, Wang J, Wang J, Han J, Deng Y, Yi X, Gao F, Huang J. An epigenomic landscape of cervical intraepithelial neoplasia and cervical cancer using single-base resolution methylome and hydroxymethylome. Clin Transl Med. 2021 Jul;11(7):e498. doi: 10.1002/ctm2.498. PMID: 34323415; PMCID: PMC8288011.

4. Qi H, Ma M, Hu C, Xu ZW, Wu FL, Wang N, Lai DY, Li Y, Zhang H, Jiang HW, Meng QF, Guo S, Kang Y, Zhao X, Li H, Tao SC. Antibody Binding Epitope Mapping (AbMap) of Hundred Antibodies in a Single Run. Mol Cell Proteomics. 2021;20:100059. doi: 10.1074/mcp.RA120.00231 Epub 2021 Feb 11. PMID: 33109704; PMCID: PMC8027275.

5. Li Y, Xu Z, Lei Q, Lai DY, Hou H, Jiang HW, Zheng YX, Wang XN, Wu J, Ma ML, Zhang B, Chen H, Yu C, Xue JB, Zhang HN, Qi H, Guo SJ, Zhang Y, Lin X, Yao Z, Sheng H, Sun Z, Wang F, Fan X, Tao SC. Antibody landscape against SARS-CoV-2 reveals significant differences between non-structural/accessory and structural proteins. Cell Rep. 2021 Jul 13;36(2):109391. doi: 10.1016/j.celrep.2021.109391. Epub 2021 Jun 26. PMID: 34242574; PMCID: PMC8233850.

6. Mengna Lin; Honglin Xu; Yi Shi; Lin-Tai Da. Antigenic Peptide Loading into Major Histocompatibility Complex Class I Is Driven by the Substrate N-Terminus. CCS Chem. 2021, 3, 979–994. DOI: 10.31635/ccschem.021.202000657

7. Shang XY, Shi Y, He DD, Wang L, Luo Q, Deng CH, Qu YL, Wang N, Han ZG. ARID1A deficiency weakens BRG1-RAD21 interaction that jeopardizes chromatin compactness and drives liver cancer cell metastasis. Cell Death Dis. 2021 Oct 23;12(11):990. doi: 10.1038/s41419-021-04291-6. PMID: 34689165; PMCID: PMC8542038.

8. Qi H, Ma M, Lai D, Li Y, Zhang F, Tao SC. Assessment and comparison of recombinant proteins from different sources for the detection of SARS-CoV-2 infection by using protein microarray. Acta Biochim Biophys Sin (Shanghai). 2021 Feb 4;53(2):262-264. doi: 10.1093/abbs/gmaa152. PMID: 33347529; PMCID: PMC7799237.

9. Tian J, Wang L, Da LT. Atomic resolution of short-range sliding dynamics of thymine DNA glycosylase along DNA minor-groove for lesion recognition. Nucleic Acids Res. 2021 Feb 22;49(3):1278-1293. doi: 10.1093/nar/gkaa1252. PMID: 33469643; PMCID: PMC7897493.

10. Jing W, Dong S, Luo X, Liu J, Wei B, Du W, Yang L, Luo H, Wang Y, Wang S, Lu H. Berberine improves colitis by triggering AhR activation by microbial tryptophan catabolites. Pharmacol Res. 2021 Feb;164:105358. doi: 1016/j.phrs.2020.105358. Epub 2020 Dec 4. PMID: 33285228.

11. He K, Wang GX, Zhao LN, Cui XF, Su XB, Shi Y, Xie TP, Hou SW, Han ZG. Cinobufagin Is a Selective Anti-Cancer Agent against Tumors with EGFR Amplification and PTEN Deletion. Front Pharmacol. 2021 Nov 29;12:775602. doi: 10.3389/fphar.2021.775602. PMID: 34925034; PMCID: PMC8672866.

12. Su X, Zhao L, Shi Y, Zhang R, Long Q, Bai S, Luo Q, Lin Y, Zou X, Ghazanfar S, Tao K, Yang G, Wang L, He KY, Cui X, He J, Wu JX, Han B, Yan B, Deng B, Wang N, Li X, Yang P, Hou S, Sun J, Yang JYH, Chen J, Han ZG. Clonal evolution in liver cancer at single-cell and single-variant resolution. J Hematol Oncol. 2021 Feb 2;14(1):22. doi: 10.1186/s13045-021-01036-y. PMID: 33531041; PMCID: PMC7852352.

13. Shi J, Ku X, Zou X, Hou J, Yan W, Zhang Y. Comprehensive analysis of O-glycosylation of amyloid precursor protein (APP) using targeted and multi-fragmentation MS strategy. Biochim Biophys Acta Gen Subj. 2021 Oct;1865(10):129954. doi: 10.1016/j.bbagen.2021.129954. Epub 2021 Jul 3. PMID: 34229070.

14. Tan S, Zhang M, Shi X, Ding K, Zhao Q, Guo Q, Wang H, Wu Z, Kang Y, Zhu T, Sun J, Zhao X. CPSF6 links alternative polyadenylation to metabolism adaption in hepatocellular carcinoma progression. J Exp Clin Cancer Res. 2021 Mar 1;40(1):85. doi: 10.1186/s13046-021-01884-z. PMID: 33648552; PMCID: PMC7923339.

15. Zhang HN, Xue JB, Wang AZ, Jiang HW, Merugu SB, Li DW, Tao SC. EASINESS: E. coli Assisted Speedy affINity-maturation Evolution SyStem. Front Immunol. 2021 Dec 3;12:747267. doi: 10.3389/fimmu.2021.747267. PMID: 34925322; PMCID: PMC8677947.

16. Xue JB, Tao SC. Epitope Analysis of Anti-SARS-CoV-2 Neutralizing Antibodies. Curr Med Sci. 2021 Dec;41(6):1065-1074. doi: 10.1007/s11596-021-2453-8. Epub 2021 Oct 4. PMID: 34606064; PMCID: PMC8488073.

17. Khan IU, Brooks G, Guo NN, Chen J, Guo F. Fever-range hyperthermia promotes cGAS-STING pathway and synergizes DMXAA-induced antiviral immunity. Int J Hyperthermia. 2021;38(1):30-37. doi: 10.1080/02656736.2020.1868582. PMID: 33444507.

18. Wang T, Liu J, Luo X, Hu L, Lu H. Functional metabolomics innovates therapeutic discovery of traditional Chinese medicine derived functional compounds. Pharmacol Ther. 2021 Aug;224:107824. doi: 10.1016/j.pharmthera.2021.107824. Epub 2021 Mar 2. PMID: 33667524.

19. Liu X, Wu W, Cui D, Chen X, Li W. Functional Micro-/Nanomaterials for Multiplexed Biodetection. Adv Mater. 2021 Jul;33(30):e2004734. doi: 10.1002/adma.202004734. Epub 2021 Jun 17. PMID: 34137090.

20. Zhao J, Fu X, Chen H, Min L, Sun J, Yin J, Guo J, Li H, Tang Z, Ruan Y, Wang X, Sun Y, Huang L. G3BP1 interacts with YWHAZ to regulate chemoresistance and predict adjuvant chemotherapy benefit in gastric cancer. Br J Cancer. 2021 Jan;124(2):425-436. doi: 10.1038/s41416-020-01067-1. Epub 2020 Sep 29. PMID: 32989225; PMCID: PMC7852868.

21. Zhou T, Gao D, Li JX, Xu MJ, Xu J. Identification of an α-Oxoamine Synthase and a One-Pot Two-Step Enzymatic Synthesis of α-Amino Ketones. Org Lett. 2021 Jan 1;23(1):37-41. doi: 10.1021/acs.orglett.0c03600. Epub 2020 Dec 7. PMID: 33284636.

22. Bao C, An N, Xie H, Xu L, Zhou B, Luo J, Huang W, Huang J. Identifying Potential Neoantigens for Cervical Cancer Immunotherapy Using Comprehensive Genomic Variation Profiling of Cervical Intraepithelial Neoplasia and Cervical Cancer. Front Oncol. 2021 Jun 17;11:672386. doi: 10.3389/fonc.2021.672386. PMID: 34221990; PMCID: PMC8249860.

23. Sun X, Wang N, Xie Y, Chu H, Wang Y, Wang Y. In-situ anchoring bimetallic nanoparticles on covalent organic framework as an ultrasensitive electrochemical sensor for levodopa detection. Talanta. 2021 Apr 1;225:122072. doi: 10.1016/j.talanta.2020.122072. Epub 2021 Jan 2. PMID: 33592790.

24. Zhuang H, Karvinen S, Törmäkangas T, Zhang X, Ojanen X, Velagapudi V, Alen M, Britton SL, Koch LG, Kainulainen H, Cheng S, Wiklund P. Interactive effects of aging and aerobic capacity on energy metabolism-related metabolites of serum, skeletal muscle, and white adipose tissue. Geroscience. 2021 Dec;43(6):2679-2691. doi: 10.1007/s11357-021-00387-1. Epub 2021 Jun 5. PMID: 34089174; PMCID: PMC8602622.

25. Yan P, Li Z, Xiong J, Geng Z, Wei W, Zhang Y, Wu G, Zhuang T, Tian X, Liu Z, Liu J, Sun K, Chen F, Zhang Y, Zeng C, Huang Y, Zhang B. LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity. Cell Rep. 2021 Nov 23;37(8):110038. doi: 10.1016/j.celrep.2021.110038. PMID: 34818543.

26. Yu H, Zhang F, Yan P, Zhang S, Lou Y, Geng Z, Li Z, Zhang Y, Xu Y, Lu Y, Chen C, Wang D, Zhu W, Hu X, Wang J, Zhuang T, Zhang Y, Wu G, Liu J, Zeng C, Pu WT, Sun K, Zhang B. LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis. Circulation. 2021 May 18;143(20):2007-2022. doi: 10.1161/CIRCULATIONAHA.120.050812. Epub 2021 Mar 5. PMID: 33663221.

27. Liang X, Wu S, Geng Z, Liu L, Zhang S, Wang S, Zhang Y, Huang Y, Zhang B. LARP7 Suppresses Endothelial-to-Mesenchymal Transition by Coupling With TRIM28. Circ Res. 2021 Oct 15;129(9):843-856. doi: 10.1161/CIRCRESAHA.121.319590. Epub 2021 Sep 10. PMID: 34503347.

28. Ling S, Yang S, Hu X, Yin D, Dai Y, Qian X, Wang D, Pan X, Hong J, Sun X, Yang H, Paludan SR, Cai Y. Lentiviral delivery of co-packaged Cas9 mRNA and a Vegfa-targeting guide RNA prevents wet age-related macular degeneration in mice. Nat Biomed Eng. 2021 Feb;5(2):144-156. doi: 10.1038/s41551-020-00656-y. Epub 2021 Jan 4. PMID: 33398131.

29. Li Y, Ma ML, Lei Q, Wang F, Hong W, Lai DY, Hou H, Xu ZW, Zhang B, Chen H, Yu C, Xue JB, Zheng YX, Wang XN, Jiang HW, Zhang HN, Qi H, Guo SJ, Zhang Y, Lin X, Yao Z, Wu J, Sheng H, Zhang Y, Wei H, Sun Z, Fan X, Tao SC. Linear epitope landscape of the SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients. Cell Rep. 2021 Mar 30;34(13):108915. doi: 10.1016/j.celrep.2021.108915. Epub 2021 Mar 12. PMID: 33761319; PMCID: PMC7953450.

30. Nagai-Okatani C, Zou X, Fujita N, Sogabe I, Arakawa K, Nagai M, Angata K, Zhang Y, Aoki-Kinoshita KF, Kuno A. LM-GlycomeAtlas Ver. 2.0: An Integrated Visualization for Lectin Microarray-based Mouse Tissue Glycome Mapping Data with Lectin Histochemistry. J Proteome Res. 2021 Apr 2;20(4):2069-2075. doi: 10.1021/acs.jproteome.0c00907. Epub 2021 Mar 4. PMID: 33657805.

31. Wu JX, He KY, Zhang ZZ, Qu YL, Su XB, Shi Y, Wang N, Wang L, Han ZG. LZP is required for hepatic triacylglycerol transportation through maintaining apolipoprotein B stability. PLoS Genet. 2021 Feb 16;17(2):e1009357. doi: 10.1371/journal.pgen.1009357. PMID: 33591966; PMCID: PMC7909667.

32. Li S, Liu Y, Liu X, Lan B, Li W, Guo F. Magnetite Fe3O4 Nanoparticles Enhance Mild Microwave Ablation of Tumor by Activating the IRE1-ASK1-JNK Pathway and Inducing Endoplasmic Reticulum Stress. Int J Nanomedicine. 2021 Sep 3;16:6129-6140. doi: 10.2147/IJN.S312823. PMID: 34511910; PMCID: PMC8423452.

33. Guo R, Luo X, Liu J, Lu H. Mass spectrometry based targeted metabolomics precisely characterized new functional metabolites that regulate biofilm formation in Escherichia coli. Anal Chim Acta. 2021 Feb 8;1145:26-36. doi: 10.1016/j.aca.2020.12.021. Epub 2020 Dec 17. PMID: 33453877.

34. Tang Y, Jia Z, Xu H, Da LT, Wu Q. Mechanism of REST/NRSF regulation of clustered protocadherin α genes. Nucleic Acids Res. 2021 May 7;49(8):4506-4521. doi: 10.1093/nar/gkab248. PMID: 33849071; PMCID: PMC8096226.

35. Luo X, Liu J, Wang H, Lu H. Metabolomics identified new biomarkers for the precise diagnosis of pancreatic cancer and associated tissue metastasis. Pharmacol Res. 2020 Jun;156:104805. doi: 10.1016/j.phrs.2020.104805. Epub 2020 Apr 8. Erratum in: Pharmacol Res. 2021 Jul;169:105657. PMID: 32278036.

36. Guo R, Luo X, Xin X, Liu L, Wang X, Lu H. Microbial Metabolomics: From Methods to Translational Applications. Adv Exp Med Biol. 2021;1280:97-113. doi: 10.1007/978-3-030-51652-9_7. PMID: 33791977.

37. Guo Q, Zheng Y, Lin J, Xu Y, Hu C, Zong J, Lu T, Xu H, Chen B, Liang Q, Xiao Y, Pan J, Lin S. Modified reduced-volume intensity-modulated radiation therapy in non-metastatic nasopharyngeal carcinoma: A prospective observation series. Radiother Oncol. 2021 Mar;156:251-257. doi: 10.1016/j.radonc.2020.12.035. Epub 2021 Jan 5. PMID: 33418007.

38. Feng J, Li YP, Hu Y, Zhou Y, Zhang H, Wu F. Novel Quinic Acid Glycerates from Tussilago farfara Inhibit Polypeptide GalNAc-Transferase. Chembiochem. 2022 Feb 4;23(3):e202100539. doi: 10.1002/cbic.202100539. Epub 2021 Dec 9. PMID: 34850523.

39. Zheng YX, Wang L, Kong WS, Chen H, Wang XN, Meng Q, Zhang HN, Guo SJ, Jiang HW, Tao SC. Nsp2 has the potential to be a drug target revealed by global identification of SARS-CoV-2 Nsp2-interacting proteins. Acta Biochim Biophys Sin (Shanghai). 2021 Aug 31;53(9):1134-1141. doi: 10.1093/abbs/gmab088. PMID: 34159380.

40. Sun Y, Yu L, Liu C, Ye S, Chen W, Li D, Huang W. One-tube SARS-CoV-2 detection platform based on RT-RPA and CRISPR/Cas12a. J Transl Med. 2021 Feb 16;19(1):74. doi: 10.1186/s12967-021-02741-5. PMID: 33593370; PMCID: PMC7884969.

41. Qi H, Ma M, Lai D, Tao SC. Phage display: an ideal platform for coupling protein to nucleic acid. Acta Biochim Biophys Sin (Shanghai). 2021 Mar 26;53(4):389-399. doi: 10.1093/abbs/gmab006. PMID: 33537750.

42. Yu X, Liu X, Yang K, Chen X, Li W. Pnictogen Semimetal (Sb, Bi)-Based Nanomaterials for Cancer Imaging and Therapy: A Materials Perspective. ACS Nano. 2021 Feb 23;15(2):2038-2067. doi: 10.1021/acsnano.0c07899. Epub 2021 Jan 23. PMID: 33486944.

43. Jia W, Zou X, Xu Z, Bai L, Shan A, Li Y, Shi J, Yang F, Ding C, Narimatsu H, Zhang Y. Polypeptide N-acetylgalactosaminyltransferase 18 retains in endoplasmic reticulum depending on its luminal regions interacting with ER resident UGGT1, PLOD3 and LPCAT1. Glycobiology. 2021 Sep 9;31(8):947-958. doi: 10.1093/glycob/cwab031. PMID: 33909026.

44. Tian T, Xu X, Li X, Zhang W, Lu H. Precision-characterization and quantitative determination of main compounds in Si-Ni-San with UHPLC-MS/MS based targeted-profiling method. J Pharm Biomed Anal. 2021 Feb 5;194:113816. doi: 10.1016/j.jpba.2020.113816. Epub 2020 Dec 5. PMID: 33339640.

45. Ji L, Fu J, Hao J, Ji Y, Wang H, Wang Z, Wang P, Xiao H. Proteomics analysis of tissue small extracellular vesicles reveals protein panels for the reoccurrence prediction of colorectal cancer. J Proteomics. 2021 Oct 30;249:104347. doi: 10.1016/j.jprot.2021.104347. Epub 2021 Aug 9. PMID: 34384913.

46. Zheng J, Suo L, Zhou Y, Jia L, Li J, Kuang Y, Cui D, Zhang X, Wu Q. Pyk2 suppresses contextual fear memory in an autophosphorylation-independent manner. J Mol Cell Biol. 2022 Jan 21;13(11):808-821. doi: 10.1093/jmcb/mjab057. PMID: 34529077; PMCID: PMC8782590.

47. Ren HH, Niu Z, Guo R, Fu M, Li HR, Zhang XY, Yao L. Rhodiola crenulata extract decreases fatty acid oxidation and autophagy to ameliorate pulmonary arterial hypertension by targeting inhibiton of acylcarnitine in rats. Chin J Nat Med. 2021 Feb;19(2):120-133. doi: 10.1016/S1875-5364(21)60013-4. PMID: 33641783.

48. Shi X, Ding K, Zhao Q, Li P, Kang Y, Tan S, Sun J. Suppression of CPSF6 Enhances Apoptosis Through Alternative Polyadenylation-Mediated Shortening of the VHL 3'UTR in Gastric Cancer Cells. Front Genet. 2021 Sep 14;12:707644. doi: 10.3389/fgene.2021.707644. PMID: 34594359; PMCID: PMC8477001.

49. Li XC, Yang HR, Hu ZY, Jin X, Zhang WY, Guo XX: Synthesis of 4(3H)-Quinazolinones by Visible-Light-Induced 2-Benzylaminobenzamides. Chin J Org Chem 2021, 41(8):3083-3088.

50. Li Y, Lai DY, Lei Q, Xu ZW, Wang F, Hou H, Chen L, Wu J, Ren Y, Ma ML, Zhang B, Chen H, Yu C, Xue JB, Zheng YX, Wang XN, Jiang HW, Zhang HN, Qi H, Guo SJ, Zhang Y, Lin X, Yao Z, Pang P, Shi D, Wang W, Yang X, Zhou J, Sheng H, Sun Z, Shan H, Fan X, Tao SC. Systematic evaluation of IgG responses to SARS-CoV-2 spike protein-derived peptides for monitoring COVID-19 patients. Cell Mol Immunol. 2021 Mar;18(3):621-631. doi: 10.1038/s41423-020-00612-5. Epub 2021 Jan 22. PMID: 33483707; PMCID: PMC7821179.

51. Zhou Y, Xu S, Zhang M, Wu Q. Systematic functional characterization of antisense eRNA of protocadherin α composite enhancer. Genes Dev. 2021 Oct 1;35(19-20):1383-1394. doi: 10.1101/gad.348621.121. Epub 2021 Sep 16. PMID: 34531317; PMCID: PMC8494205.

52. Qi H, Ma ML, Jiang HW, Ling JY, Chen LY, Zhang HN, Lai DY, Li Y, Guo ZW, Hu CS, Guo SJ, Meng QF, Ren Y, Yang X, Wang W, Zhou J, Zhao XD, Li H, Tao SC. Systematic profiling of SARS-CoV-2-specific IgG epitopes at amino acid resolution. Cell Mol Immunol. 2021 Apr;18(4):1067-1069. doi: 10.1038/s41423-021-00654-3. Epub 2021 Mar 4. PMID: 33664486; PMCID: PMC7931502.

53. Ma ML, Shi DW, Li Y, Hong W, Lai DY, Xue JB, Jiang HW, Zhang HN, Qi H, Meng QF, Guo SJ, Xia DJ, Hu JJ, Liu S, Li HY, Zhou J, Wang W, Yang X, Fan XL, Lei Q, Chen WJ, Li CS, Yang XM, Xu SH, Wei HP, Tao SC. Systematic profiling of SARS-CoV-2-specific IgG responses elicited by an inactivated virus vaccine identifies peptides and proteins for predicting vaccination efficacy. Cell Discov. 2021 Aug 17;7(1):67. doi: 10.1038/s41421-021-00309-7. PMID: 34400612; PMCID: PMC8367966.

54. Yin D, Ling S, Wang D, Dai Y, Jiang H, Zhou X, Paludan SR, Hong J, Cai Y. Targeting herpes simplex virus with CRISPR-Cas9 cures herpetic stromal keratitis in mice. Nat Biotechnol. 2021 May;39(5):567-577. doi: 10.1038/s41587-020-00781-8. Epub 2021 Jan 11. PMID: 33432198; PMCID: PMC7611178.

55. Ma M, Qi H, Hu C, Xu Z, Wu F, Wang N, Lai D, Li Y, Zhang H, Jiang H, Meng Q, Guo S, Kang Y, Zhao X, Li H, Tao SC. The binding epitope of sintilimab on PD-1 revealed by AbMap. Acta Biochim Biophys Sin (Shanghai). 2021 Apr 15;53(5):628-635. doi: 10.1093/abbs/gmab020. PMID: 33637989.

56. Huang W, Lin D, Wang C, Bao C, Zhang Z, Chen X, Zhang Z, Huang J. The determination of release from isolation of COVID-19 patients requires ultra-high sensitivity nucleic acid test technology. J Infect. 2021 Jan;82(1):159-198. doi: 10.1016/j.jinf.2020.06.075. Epub 2020 Jul 2. PMID: 32622906; PMCID: PMC7330563.

57. Xie Y, Wang N, Sun X, Chu H, Wang Y, Hu X. Triple-signaling amplification strategy based electrochemical sensor design: boosting synergistic catalysis in metal-metalloporphyrin-covalent organic frameworks for sensitive bisphenol A detection. Analyst. 2021 Jul 21;146(14):4585-4594. doi: 10.1039/d1an00665g. Epub 2021 Jun 22. PMID: 341599

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