师资队伍

万兵兵

长聘教轨副教授、博导

 

电话: (Tel) +86-021-3420-4251 (Wan Lab), 021-3420-6059 (Admin Office)
传真:
邮箱: (Email) wanb@sjtu.edu.cn
主页: https://wanlab.sjtu.edu.cn

学习经历
(Education:)
2003.09-2009.07 复旦大学/国家人类基因组南方研究中心 遗传学专业 获博士学位 (硕博连读)
(2003.09-2009.07 Fudan University/Chinese Human Genome Center at Shanghai, PhD in Genetics, Shanghai, China)
1998.09-2002.07 湖北大学 生物工程专业 获学士学位
(1998.09-2002.07 Hubei University, Bachelor of Science in Biology, Wuhan, China)

 

工作经历
(Research Experience:)
2020.10-至今 上海交通大学系统生物医学研究院 特别研究员/博士生导师
(2020.10-Now, Tenure-track Associated Professor/Principal Investigator, Shanghai Jiao Tong University, Shanghai Center for Systems Biomedicine, Shanghai, China)
2014.09-2020.09 美国纽约纪念斯隆-凯特琳癌症中心 博士后副研究员
(2014.09-2020.09 Postdoctoral Research Associate, Memorial Sloan Kettering Cancer Center [MSKCC], New York, USA)
2009.07-2014.08 美国密西根大学生化系/HHMI 从事博士后研究
(2009.07-2014.08 Postdoctoral Research Fellow, University of Michigan/Howard Hughes Medical Institute, Ann Arbor, Michigan, USA)

 

人才奖项
(Honors:)
2021年入选上海海外高层次人才计划
(Sponsored by the Talent Program of Shanghai Municipality in 2021)
2020年入选上海交通大学长聘体系(Tenure-Track)教职 (绿色通道引进高层次人才)
(Sponsored by the Talent Program of Shanghai Jiao Tong University in 2020)
2019年入选纪念斯隆-凯特琳癌症中心十大基础研究突破之一
(Selected as 1 of 10 Remarkable Basic Science Breakthroughs of MSKCC in 2019, New York, USA)
2018年获纪念斯隆-凯特琳协会学者奖
(Granted The Society of Memorial Sloan-Kettering Scholars Prize in 2018, New York, USA)

 

学会兼职与审稿人
(Academic Activities:)
中国细胞生物学学会CSCB会员
AAAS (American Association for the Advancement of Science) 协会会员 (AAAS Membership)
NYAS (New York Academy of Sciences) 协会会员 (NYAS Membership)
Aging, J Cancer, Int J Biol Sci 等杂志审稿人 (Reviewer of the journals: Aging, J Cancer, Int J Biol Sci)

DNA损伤修复与端粒的功能研究 (Research Areas: DNA damage repair and telomere biology)
1. 人染色体端粒长度维持的分子机制及其与癌症和衰老的关系研究
(Telomere Maintenance of telomere-binding proteins and its roles in cancer and aging)
2. 维持酵母基因组稳定性起重要作用的DNA损伤修复蛋白的作用机制研究
(Mechanistic studies of the role of DNA damage response protein in genome maintenance of Saccharomyces cerevisiae)
3. 人的肿瘤发生发展密切相关的DNA损伤修复蛋白的作用机制研究与应用
(Mechanistic studies of the association of DNA damage response protein and human tumorigenesis)

(Publications:)
1. Ma Y, Huang C, Tang T, Wu B, Xue H, Cao Y, Wu J, Wan B* and Lei M*. Structural and functional insights into CST tethering in Tetrahymena thermophila telomerase, Structure, 2022, 30(12): 1563-1564. (* corresponding author) .

2. Yu Y, Li S, Ser Z, Sanyal T, Choi K, Wan B, Kuang H, Sali A, Kentsis A, Patel DJ, Zhao X. Integrative analysis reveals unique structural and functional features of the Smc5/6 complex. Proc Natl Acad Sci U S A, 2021, 118(19):e2026844118. PMID: 33941673.

3. Li S, Bonner JN, Wan B, So S, Summers A, Gonzalez L, Xue X, Zhao X. Esc2 orchestrates substrate-specific sumoylation by acting as a SUMO E2 cofactor in genome maintenance. Genes Dev. 2021, 35(3-4): 261-272. PMID: 33446573

4. Wan B, Wu J, Meng X, Lei M, Zhao X. Molecular basis for control of diverse genome stability factors by the multi-BRCT scaffold Rtt107. Mol Cell. 2019, 75(2):238-251. PMID: 31348879.

5. Shultis D., Mitra P., Huang X., Johnson J., Khattak N.A., Gray F., Piper C., Czajka J., Hansen L., Wan B., Chinnaswamy K., Liu L., Wang M., Pan J., Stuckey J., Cierpicki T., Borchers C.H., Wang S., Lei M., Zhang Y. Changing the Apoptosis Pathway through Evolutionary Protein Design. J Mol Biol. 2019, 431(4):825-841. PMID: 30625288.

6. Bonner JN, Choi K, Xue X, Torres NP, Szakal B, Wei L, Wan B, Arter M, Matos J, Sung P, Brown GW, Branzei D, Zhao X. Smc5/6 mediated sumoylation of the Sgs1-Top3-Rmi1 complex promotes removal of recombination intermediates. Cell Rep. 2016,16(2):368-378. PMID: 27373152.

7. Yin J#, Wan B#, Sarkar J#, Horvath K, Wu J, Chen Y, Cheng G, Wan K, Chin P, Lei M*, Liu Y*. Dimerization of SLX4 contributes to functioning of the SLX4-nuclease complex. Nucl Acids Res. 2016,44(10):4871-4880. PMID: 27131364 (* equal contribution)

8. Wan B, Hang L, Zhao X. Multi-BRCT scaffolds use distinct strategies to support genome maintenance. Cell Cycle. 2016,15(19):2561-2570. PMID: 27580271.

9. Wan B#, Tang T#, Upton H, Shuai J, Zhou Y, Li S, Chen J, Brunzelle JS, Zeng Z, Collins K, Wu J*, Lei M*. The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex. Nat Struct Mol Biol. 2015,22(12):1023-1026. PMID: 26551074. (* equal contribution)

10. Sarkar J, Wan B, Yin J, Vallabhaneni H, Horvath K, Kulikowicz T, Bohr VA, Zhang Y, Lei M, Liu Y. SLX4 contributes to telomere preservation and regulated processing of telomeric joint molecule intermediates. Nucl Acids Res. 2015,43(12):5912-5923. PMID: 25990736.

11. Yang YW, Flynn RA, Chen Y, Qu K, Wan B, Wang KC, Lei M, Chang HY. Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency. Elife. 2014, 3:e02046. PMID: 24521543.

12. Sommers JA, Banerjee T, Hinds T, Wan B, Wold MS, Lei M and Brosh RM. Novel function of the fanconi anemia group J or RECQ1 helicase to disrupt protein-DNA complexes in a replication protein a-stimulated manner. J Biol Chem. 2014,289(29):19928-19941. PMID: 24895130.

13. Wan B#, Yin J#, Horvath K#, Sarkar J, Chen Y, Wu J, Wan K, Lu J, Gu P, Yu EY, Lue NF, Chang S, Liu Y*, Lei M*. SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres. Cell Rep. 2013,4(5):861-869. PMID: 24012755. (* equal contribution)

14. Zhou J, Wan B, Shan J, Shi H, Li Y, Huo K. PTPN4 negatively regulates CrkI in human cell lines. Cell Mol Biol Lett. 2013,18(2):297-314. PMID: 23666597.

15. Huang J, Gurung B*, Wan B*, Matkar S, Veniaminova NA, Wan K, Merchant JL, Hua X, Lei M. The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature 2012,482(7386):542-546. PMID: 22327296. (* equal contribution)

16. Chen Y, Cao F, Wan B, Dou Y, Lei M. Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30. Cell Res. 2012,22(3):598-602. PMID: 22231628.

17. Huang J, Wan B, Wu L, Yang Y, Dou Y, Lei M. Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex. Cell Res. 2012,22(6):1078-1081. PMID: 22547026.

18. Chen Y*, Wan B*, Wang KC*, Cao F, Yang Y, Protacio A, Dou Y, Chang HY, Lei M. Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding. EMBO Rep. 2011,12(8):797-803. PMID: 21660059. (* equal contribution)

19. Xu X, Liu RF, Wan BB, Xing WM, Huang J, Han ZG. Expression of a novel gene FAM43B repressing cell proliferation is regulated by DNA methylation in hepatocellular carcinoma cell lines. Mol Cell Biochem. 2011,354(1-2):11-20. PMID: 21461611.

20. Huang J, Zheng DL, Qin FS, Cheng N, Chen H, Wan BB, Wang YP, Xiao HS, Han ZG. Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling. J Clin Invest. 2010,120(1):223-241. PMID: 20038795.

21. Wan B, Wang XR, Zhou YB, Zhang X, Huo K, Han ZG. C12ORF39, a novel secreted protein with a typical amidation processing signal. Biosci Rep. 2010,30(1):1-10. PMID: 19193193.

22. Li T, Wan B, Huang J. Comparison of gene expression in hepatocellular carcinoma, liver development and liver regeneration. Mol Genet Genomics. 2010,283(5):485-492. PMID: 20358383.

23. Wan B, Zhou YB, Zhang X, Zhu H, Huo K, Han ZG. hOLFML1, a novel secreted glycoprotein, enhances the proliferation of human cancer cell lines in vitro. FEBS Lett. 2008,582(21-22):3185-3192. PMID: 18708057.

24. Zhou YB*, Cao JB*, Wan BB*, Wang XR, Ding GH, Zhu H, Yang HM, Wang KS, Zhang X, Han ZG. hBolA, novel non-classical secreted proteins, belonging to different BolA family with functional divergence. Mol Cell Biochem. 2008,317(1-2):61-68. PMID: 18548201. (* equal contribution)

25. Li L, Shi Y, Wu H, Wan B, Li P, Zhou L, Shi H, Huo K. Hepatocellular carcinoma-associated gene 2 interacts with MAD2L2. Mol Cell Biochem. 2007,304(1-2):297-304. PMID: 17541814.

1. 2022.04-2025.03 上海市科委自然科学基金面上项目:22ZR1432700 (端粒方向),在研,主持
2. 2022.03-2027.03上海交通大学 产学研合作项目:新一代测序酶的研制 (22H010100767) ,在研,主持
3. 2022.01-2025.12 国家自然科学基金委面上项目:32170087 (DNA损伤修复方向),在研,主持
4. 2021.07-2023.07 转化医学国家重大基础设施(上海)开放课题:TMSK-2021-132 (DNA损伤修复与乳腺癌方向),在研,主持
5. 2021.01-2026.12 上海交通大学“双一流”建设高层次人才计划科研项目:BRCT结构域对基因组稳定性维持的分子机制研究,在研,主持
6. 2021.01-2026.12 上海交通大学 产学研合作项目:新一代高性能DNA 聚合酶研发项目 (21H010102507),在研,主持

此外还受上海市海外高层次人才计划项目资助。

已授权专利:
1. 中国专利授权公开号:CN113481229A,一种获得大肠杆菌超级感受态细胞的制备方法。曲红金,吕妍,万兵兵,曹禺,汪子喻,李俊实
1. 中国专利授权公开号:CN101003805A,人C10ORF58基因、其编码蛋白及应用。 韩泽广,万兵兵,黄健

(Lab members:)
博士后:
曲红金(获上海交通大学“晨星”博士后激励计划资助,毕业于海军军医大学)

博士生:
曹禺(2021级,毕业于大连理工大学),胡黎明(2022级,毕业于兰州大学),罗思敏(2023级,毕业于上海交通大学医学院)

硕士生:
罗洋(2021级,获上海交大一等新生奖学金,毕业于四川大学)
杨丝丝(2022级,重庆三峡学院联合培养,毕业于天津科技大学)

其它学习过的学生:
李俊实(2021,海军军医大学)
黄逸飞(2021,The University of Queensland, Australia)


计划招聘一名助理研究员/副研究员,招收博士研究生,硕士研究生,联合培养研究生,博士后若干名。
(Now, Wan Lab has 1 postdoctoral research fellow, 2 PhD candidate student, 1 Master student of SJTU, 1 joint-program Master student. Wan Lab is planning to recruit 1 assistant/associate investigator and more graduate students from China or abroad.)

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