师资队伍

万兵兵

长聘教轨副教授、博导

 

电话: (Tel) +86-021-3420-4251 (Wan Lab), 021-3420-6059 (Admin Office)
传真:
邮箱: (Email) wanb@sjtu.edu.cn
主页: (Wan Lab homepage) https://scsb.sjtu.edu.cn/Professor/12269.html

学习经历
(Education:)
2003.09-2009.07 复旦大学/国家人类基因组南方研究中心 遗传学专业 获博士学位 (硕博连读)
(2003.09-2009.07 Fudan University/Chinese Human Genome Center at Shanghai, PhD in Genetics, Shanghai, China)
1998.09-2002.07 湖北大学 生物工程专业 获学士学位
(1998.09-2002.07 Hubei University, Bachelor of Science in Biology, Wuhan, China)

 

工作经历
(Research Experience:)
2020.10-至今 上海交通大学系统生物医学研究院 特别研究员/博士生导师
(2020.10-Now, Tenure-track Associated Professor/Principal Investigator, Shanghai Jiao Tong University, Shanghai Center for Systems Biomedicine, Shanghai, China)
2014.09-2020.09 美国纽约纪念斯隆-凯特琳癌症中心 博士后副研究员
(2014.09-2020.09 Postdoctoral Research Associate, Memorial Sloan Kettering Cancer Center [MSKCC], New York, USA)
2009.07-2014.08 美国密西根大学生化系/HHMI 从事博士后研究
(2009.07-2014.08 Postdoctoral Research Fellow, University of Michigan/Howard Hughes Medical Institute, Ann Arbor, Michigan, USA)

 

人才奖项
(Honors:)
2021年入选上海海外高层次人才计划
(Sponsored by the Talent Program of Shanghai Municipality in 2021)
2020年入选上海交通大学长聘体系(Tenure-Track)教职 (绿色通道引进高层次人才)
(Sponsored by the Talent Program of Shanghai Jiao Tong University in 2020)
2019年入选纪念斯隆-凯特琳癌症中心十大基础研究突破之一
(Selected as 1 of 10 Remarkable Basic Science Breakthroughs of MSKCC in 2019, New York, USA)
2018年获纪念斯隆-凯特琳协会学者奖
(Granted The Society of Memorial Sloan-Kettering Scholars Prize in 2018, New York, USA)

 

学会兼职与审稿人
(Academic Activities:)
AAAS (American Association for the Advancement of Science) 协会会员 (AAAS Membership)
NYAS (New York Academy of Sciences) 协会会员 (NYAS Membership)
Aging, J Cancer, Int J Biol Sci 等杂志审稿人 (Reviewer of the journals: Aging, J Cancer, Int J Biol Sci)

DNA损伤修复与端粒的功能研究 (Research Areas: DNA damage repair and telomere biology)
1. 维持酵母基因组稳定性起重要作用的DNA损伤修复蛋白的作用机制研究
(Mechanistic studies of the role of DNA damage response protein in genome maintenance of Saccharomyces cerevisiae)
2. 人的肿瘤发生发展密切相关的DNA损伤修复蛋白的作用机制研究与应用
(Mechanistic studies of the association of DNA damage response protein and human tumorigenesis)
3. 人染色体端粒长度维持的分子机制及其与癌症和衰老的关系研究
(Telomere Maintenance of telomere-binding proteins and its roles in cancer and aging)

(Publications:)
1. Li S, Bonner JN, Wan B, So S, Summers A, Gonzalez L, Xue X, Zhao X. Esc2 orchestrates substrate-specific sumoylation by acting as a SUMO E2 cofactor in genome maintenance. Genes Dev. 2021, 35(3-4): 261-272. PMID: 33446573
2. Wan B, Wu J, Meng X, Lei M*,Zhao X*. Molecular basis for control of diverse genome stability factors by the multi-BRCT scaffold Rtt107. Mol Cell, 2019, 75(19): 238-251. PMID: 31348879.
3. Wan B, Hang LE, Zhao X*. Multi-BRCT scaffolds use distinct strategies to support genome maintenance. Cell Cycle, 2016, 15(19): 2561-2570. PMID: 27580271.
4. Yin J#, Wan B#, Sarkar J#, Horvath K, Wu J, Chen Y, Cheng G, Wan K, Chin P, Lei M*, Liu Y*. Dimerization of SLX4 contributes to functioning of the SLX4-nuclease complex. Nucleic Acids Res, 2016, 44(10): 4871-4880. PMID: 27131364.
5. Wan B#, Tang T#, Upton H, Shuai J, Zhou Y, Li S, Chen J, Brunzelle JS, Zeng Z, Collins K, Wu J*, Lei M*. The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex. Nat. Struct. Mol. Biol, 2015, 22 (12): 1023-1026. PMID: 26551074.
6. Sarkar J, Wan B, Yin J, Vallabhaneni H, Horvath K, Kulikowicz T, Bohr VA, Zhang Y, Lei M*, Liu Y*. SLX4 contributes to telomere preservation and regulated processing of telomeric joint molecule intermediates. Nucleic Acids Res, 2015, 43(12): 5912-5923.
7. Wan B#, Yin J#, Horvath K#, Sarkar J, Chen Y, Wu J, Wan K, Lu J, Gu P, Yu EY, Lue NF, Chang S, Liu Y*, Lei M*. SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres. Cell Rep, 2013,4(5):861-869. PMID: 24012755.
8. Huang J, Gurung B#, Wan B#, Matkar S, Veniaminova NA, Wan K, Merchant JL, Hua X*, Lei M*. The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature 2012,482(7386):542-546. PMID: 22327296.
9. Huang J, Wan B, Wu L, Yang Y, Dou Y, Lei M*. Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex. Cell Res, 2012,22(6):1078-1081. PMID: 22547026.
10. Chen Y#, Wan B#, Wang KC#, Cao F, Yang Y, Protacio A, Dou Y, Chang HY*, Lei M*. Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding. EMBO Rep, 2011,12(8):797-803. PMID: 21660059.

(Lab members:) 现有1名博士后,1名博士生,1名硕士生,1名联合培养硕士生,计划招聘一名助理研究员/副研究员,招收博士研究生,硕士研究生,联合培养研究生,博士后若干名。
(Now, Wan Lab has 1 postdoctoral research fellow, 1 PhD candidate student, 1 Master student of SJTU, 1 joint-program Master student. Wan Lab is planning to recruit 1 assistant/associate investigator and more graduate students from China or abroad.)

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