师资队伍

张冰

长聘副教授、博导

 

电话: 86-21-34208691
传真:
邮箱: bingzhang@sjtu.edu.cn
主页: http://binglab.sjtu.edu.cn

学习经历
2001-2006年 山东大学医学院 博士 (优秀博士生)

 

工作经历
2018- 上海交通大学系统生物与医学研究院助理院长
2015- 特别研究员,上海交通大学系统生物与医学研究院
2017- 上海交通大学附属新华医院兼聘首席科学家
2011-2015 讲师, 哈佛大学医学院,哈佛大学波士顿儿童医院, 美国
2010-2011 博士后, 哈佛大学波士顿儿童医院, 美国
2006-2010 博士后,佐治亚大学生化与分子生物学系, 复合多糖研究中心。美国

 

人才奖项
2016 国家高层次引进人才
2016 中组部青年千人

 

学会兼职与审稿人
中国细胞生物学会发育生物学分会执委
中国细胞生物学会会员
美国血管生物学会会员
美国心脏病学会会员

1. 心血管系统再生与重大疾病关键分子机制
2. 表观遗传与转录的分子调控网络
3. 高通量测序技术研制和生物信息学软件及分析程序开发

1. Yu H, Zhang F, Yan P, Zhang S, Lou Y, Geng Z, Li Z, Zhang Y, Xu Y, Lu Y, Chen C, Wang D, Zhu W, Hu X, Wang J, Zhuang T, Zhang Y, Wu G, Liu J, Zeng C, Pu WT, Sun K, Zhang B*. LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis. Circulation. 2021 Mar 5. doi: 10.1161/CIRCULATIONAHA.120.050812. Online ahead of print.PMID: 33663221 IF>23 通讯作者
2. Yifei Miao, Lei Tian, Marcy Martin, Sharon L Paige, Francisco X Galdos, Jibiao Li, Alyssa Klein, Hao Zhang, Ning Ma, Yuning Wei, Maria Stewart, Soah Lee, Jan-Renier Moonen, Bing Zhang, Paul Grossfeld, Seema Mital, David Chitayat, Joseph C Wu, Marlene Rabinovitch ,
Timothy J Nelson , Shuyi Nie, Sean M Wu, Mingxia Gu. Intrinsic Endocardial Defects Contribute to Hypoplastic Left Heart Syndrome. Cell Stem Cell. 2020 Oct 1;27(4):574-589.e8. IF>20
3. Fang Zhang, Pengyi Yan, Huijing Yu, Huangying Le, Zixuan Li, Jiahuan Chen, Xiaodong Liang, Shiyan Wang, Weiting Wei, Li Liu, Yan Zhang, Xing Ji, Anyong Xie, Wantao Chen, Zeguang Han, William T Pu, Sun Chen, Yingwei Chen, Kun Sun, Baoxue Ge, Bing Zhang*. LARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis. Cell Rep. 2020 Aug 18;32(7):108058. IF>8 通讯作者
4. Jiahuan Chen, Xiaodong Liang, Shasha Zhang, Shiyan Wang, Sara P. Garcia, Pengyi Yan, Huijing Yu, Zixuan Li, Li Liu, Fang Zhang, Weiting Wei, Huangying Le, Yan Zhang, Guo-cheng Yuan, Sun Chen, Yingwei Chen, Kun Sun, William T. Pu, Bing Zhang*,Two faces of bivalent domain regulate VEGFA responsiveness and angiogenesis. Cell Death Dis. 2020, Jan 30;11(1):75 IF>6 通讯作者
5. Akerberg BN, Gu F, VanDusen NJ, Zhang X, Dong R, Li K, Zhang B, Zhou B, Sethi I, Ma Q, Wasson L, Wen T, Liu J, Dong K, Conlon FL, Zhou J, Yuan GC, Zhou P, Pu WT. A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers. Nat Commun. 2019 Oct 28;10(1):4907. doi: 10.1038/s41467-019-12812-3 IF>12
6. Wang S, Chen J, Garcia SP, Liang X, Zhang F, Yan P, Yu H, Wei W, Li Z, Wang J, Le H, Han Z, Luo X, Day DS, Stevens SM, Zhang Y, Park PJ, Liu ZJ, Sun K, Yuan GC*, Pu WT*, Zhang B*. A dynamic and integrated epigenetic program at distal region orchestrates transcriptional responses to VEGFA. Genome Res. 2019 Feb;29(2):193-207. doi: 10.1101/gr.239053.118 IF>12 通讯作者
7. Wang C, Chen J, Zhang Q, Li W, Zhang S, Xu Y, Wang F, Zhang B, Zhang Y, Gao WQ, Elimination of CD4lowHLA-G+ T cells overcomes castration-resistance in prostate cancer therapy, Cell Res., 2018 Oct 8. doi: 10.1038/s41422-018-0089-4 IF>14
8. Wenhua Yu, Fang Zhang, Huafeng Xie, Shiyan Wang, Yi Fu, Jiahuan Chen, Xiaodong Liang, Huangying Le, William T. Pu*, Bing Zhang*. Depletion of Polycomb Repressive Complex 2 core component EED impairs fetal hematopoiesis. Cell Death Dis. 2017 Apr 13;8(4):e2744 IF>6 通讯作者
9. Jiahuan Chen, Yi Fu, Daniel S. Day, Ye Sun, Shi-yan Wang, Xiaodong Liang, Fei Gu, Fang Zhang, Sean M. Stevens, Pingzhu Zhou, Kai Li, Yan Zhang, Ruei-zeng Lin, Lois E. H. Smith, Jin Zhang, Juan M. Melero-Martin, Ze-Guang Han, Peter J. Park, Bing Zhang*, William T. Pu* “VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis. Nat Commun. 2017 Aug 29;8(1):383. doi: 10.1038/s41467-017-00405-x IF>12 通讯作者
10. Guo H, Zhang B, Nairn AV, Nagy T, Moremen KW, Buckhaults P, Pierce M. O-GlcNAc expression levels epigenetically regulate colon cancer tumorigenesis by affecting the cancer stem cell compartment via modulating expression of transcriptional factor MYBL1. J Biol Chem. 2017 Jan 17 IF>5
11. Daniel Day, Zhang Bing*, Sean M. Stevens, Francesco Ferrari, Erica N. Larschan, Peter J Park*, William.T.PU*. Comphensive analysis of Promoter-Promximal RNA PolymeraseII Pasuing Across Mammlian Cell Types. Genome Biol. 2016 Jun 3;17(1):120. doi: 10.1186/s13059-016-0984-2. IF>11 第一作者/通讯作者
12. Zhang Q, Qin J, Zhong L, Gong L, Zhang B, Zhang Y, Gao WQ. CCL5-mediated Th2 immune polarization promotes metastasis in luminal breast cancer. Cancer Res. 2015 Aug 6. pii: canres. 3590.2014. IF>9
13. Ye Sun, Chi-Hsiu Liu, John Paul SanGiovannib, Lucy P. Evans, Katherine T. Tian, Bing Zhang, Andreas Stahld, William T. Pu, Theodore M. Kamenecka, Laura A. Solt, Jing Chen, Nuclear receptor RORα regulates pathologic retinal angiogenesis by modulating Socs3 dependent inflammation. PNAS. Proc Natl Acad Sci U S A. 2015 Aug 4. pii: 201504387 IF>9
14. Zhang Bing, William. T. PU. Notching up vascular regeneration. Cell Research 2014; doi:10.1038/ cr.2014 IF>14 第一作者/通讯作者
15. Zhang Bing, Wenyuan Xiao, Hong Qiu, Fuming Zhang, Eduard Condac, Cathy Cheng, Parastoo Azadi, John J. Greer, Dean Li, kelley Moremen, Robert Linhardt, Jeffrey D. Esko, Lianchun Wang. Congenital Diaphragmatic Hernia Results From Disruption of Developmental Angiogenesis mediated by Slit3-Robo4-Heparan Sulfate Signaling. J Clin Invest. 2014 Jan 2;124(1):209-21. IF>12 第一作者
16. Zhang Bing, Pu WT. The mysterious origins of coronary vessels. Cell Res. 2013 Jul 9.doi:10.1038/cr. 2013.90 IF>14 第一作者
17. Bing Zhang, Daniel S. Day, Joshua W. Ho, Lingyun Song, Jingjing Cao, Danos Christodoulou, Jonathan G. Seidman, Gregory E. Crawford, Peter J. Park, and William T. Pu. A dynamic H3K27ac signature defines VEGFA-regulated endothelial enhancers. Genome Res. 2013 Jun;23(6):917-27 IF>12 第一作者
18. He A, Ma Q, Cao J, von Gise A, Zhou P, Xie H, Zhang B, Hsing M, Christodoulou D, Cahan P, Daley GQ, Kong SW, Orkin SH, Seidman CE, Seidman JG, Pu WT. Polycomb Repressive Complex 2 Regulates Normal Development of the Mouse Heart. Circ Res. 2012 Feb 3;110(3):406-15. IF>14
19. Zhou B, Honor LB, He H, Ma Q, Oh JH, Butterfield C, Lin RZ, Melero-Martin JM, Dolmatova E, Duffy HS, Gise A, Zhou P, Hu YW, Wang G, Zhang B, Wang L, Hall JL, Moses MA, McGowan FX, Pu WT.Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J Clin Invest. 2011 May 2;121(5):1894-904. IF>12
20. Zhang Bing, Ursula M. Dietrich, Jian-Guo Geng, Roy Bicknell, Jeffrey D.Esko and Lianchun Wang. (2009) Repulsive axon guidance molecule Slit3 is a novel angiogenic factor. Blood. 2009 Nov 5;114(19):4300-9 IF>13 第一作者
21. Song X, Tian H, Liu XX, Zhang B, Li WJ, Xu J. (2008) Ornithine Decarboxylase and S-adenosylmethionine Decarboxylase Bi-antisense Virus Inhibit Growth and Invasion of Esophageal Cancer Cell Line Eca109. Ai Zheng. Nov;27(11):1144-9. Chinese.
22. Tian H, Liu X, Zhang B, Sun Q, Sun D. (2007) Adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase inhibits lung cancer cell growth. Acta Biochim Biophys Sin (Shanghai). Jun;39(6):423-30.
23. Gong L, Zhang B, Zhang Y, Hu H, Zhao Z, Liu X. (2007) Cloning, expression and purification of human S-adenosylmethionine decarboxylase gene alpha subunit. Chin J Physiol. Feb 28;50(1):29-33.
24. Gong L, Jiang C, Zhang B, Hu H, Wang W, Liu X. (2006) Adenovirus-mediated expression of both antisense ornithine decarboxylase and s-adenosylmethionine decarboxylase induces G1 arrest in HT-29 cells. J Biochem Mol Biol. Nov 30;39(6):730-6.
25. Zhang B, Liu XX, Zhang Y, Jiang CY, Teng QS, Hu HY, Wang W, Gong L. (2006)Adenovirus-mediated expression of both antisense ODC and AdoMetDC inhibited colorectal cancer cell growth in vitro. Acta Pharmacol Sin. Mar;27(3):353-9
26. Zhang B, Liu XX, Zhang Y, Jiang CY, Hu HY, Gong L, Liu M, Teng QS. (2006) Polyamine depletion by ODC-AdoMetDC antisense adenovirus impairs human colorectal cancer growth and invasion in vitro and in vivo. J Gene Med. Aug;8(8):980-9. 第一作者
27. Zhang Y, Liu XX, Zhang B, Hu HY, Gong L. (2005) Antitumor effect of antisense ODC adenovirus on human prostate cancer cells. Prostate Cancer Prostatic Dis.;8(3):280-6
28. Hu HY, Liu XX, Zhang B et al. (2005) Ornithine decarboxylase gene is overexpressed in colorectal carcinoma. World J Gastroenterol April; 11 (15):2244-2248
29. Zhang Y, Liu XX, Zhang B, et al. (2005) inhibition of Prostate Cancer Cells with Antisense RNA of Ornithine Decarboxylase Gene in Vitro. Chinese Journal of Biochemistry and Molecular biology, 21(1): 128
30. Zhang B, Liu XX, Zhang Y, et al. (2005) Construction of an antisense bicistronic recombinant adenovirus vector of ODC and SAMDC. Journal of Shandong University, 43(5):345
31. Zhang B, Liu XX, Zhang Y, et al. (2005) The screening of the sensitive antisense targets in the ODC mRNA. Chinese Journal of Current Advances in General Surgery, 8(5):146 第一作者
32. Zhang B, Liu XX, Gong L. (2004) The development of antisense technology(review). Oncology Section Foreign Meidcal Sciences.31 (9):674 第一作者
33. Zhang Y, Liu XX, Zhang B, et al. (2004) Inhibition of prostate cancer cell PC-3 by rAd-ODC/Ex3as. Journal of Shandong University, 42(5):423

2021-2025 上海市教育委员会科研创新计划项目 新型活性氧感受器LARP7治疗心力衰竭的机制和应用研究 上海市教委 项目负责人
2021-2023 上海交大“交大之星”计划医工交叉项目 先天性房室间隔缺损遗传机制及分子标记物的研究 上海交大 项目负责人
2019-2022 自然基金面上项目 LARP7调节血管内皮向间充质细胞转化的机制研究 国家自然基金委 项目负责人
2019-2022 上海交大医工交叉重点项目“高通量测序技术在先天性主动脉二瓣畸形诊断中的应用研究” 上海交通大学 项目负责人
2017-2021 自然基金面上项目 ETS1促转录停滞释放和血管新生的分子机制研究 国家自然基金委 项目负责人
2016-2019 “血管稳态和重构调节机制”培育项目,VEGF信号通路的系统生物学研究 国家自然基金委 项目负责人
2014-2018 Scientist Development Grant (National), 美国心脏学会 项目负责人
2020-2025 国家重点研发计划 发育编程及其代谢调节专项,运动对发育和稳态的影响 科技部 子课题负责人
2020-2021 国家自然科学基金委重大研究计划集成项目 动脉粥样硬化发生的血流动力学调控机制和干预策略研究 国家自然基金委 课题负责人
2018-2021 国家重点研发计划重点专项项目 “基于高血压肾病和 “器官不良对话”关键发病机制的综合干预研究”, 科技部 子课题负责人
2018-2021 国家重点研发计划重点专项项目 “基于立体化网络建设出生缺陷综合防控示范应用体系” 科技部 子课题负责人
2017-2022 上海市教委创新计划重大项目 先天性主动脉瓣膜病遗传与环境发病机制的研究 上海市教委 课题负责人

已授权专利

1. Wang L, Zhang B., Esko JD,Angiogenic protein and methods of use”Provisional U.S. Patent No: 61/053,295; . Issued July 2008.
2. 张冰、张芳,LARP7基因在癌症诊断和治疗中的应用,专利号 202010953449.5, 2020.11

在申请专利三项, 国际PCT专利一项。

博士后1人
博士6人(硕博连读5人;致远荣誉计划2人;交大学术之星1人; 上海市优秀毕业生1人;国家奖学金1人)
硕士2人

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