学习经历
2001-2006年 山东大学医学院 博士 （优秀博士生）

 

工作经历
2023- 先心病教育部工程中心副主任，上海交通大学医学院附属新华医院
2023- 特聘教授， 上海交通大学系统生物与医学研究院（兼）
2015- 研究员，上海交通大学系统生物与医学研究院
2011-2015 讲师， 哈佛大学医学院，哈佛大学波士顿儿童医院, 美国
2010-2011 博士后, 哈佛大学波士顿儿童医院， 美国
2006-2010 博士后，佐治亚大学生化与分子生物学系， 复合多糖研究中心，美国

 

人才奖项
2016 国家青年高层次引进人才
2022 国家杰青

 

学会兼职与审稿人
北美血管生物学会员（North American Vascular Biology Association）
上海细胞生物学会常务理事
中国细胞生物学会会员
中国发育生物学分会执行委员
全国精准医疗分会常务理事
上海细胞生物学会常务理事
上海衰老协会常务理事
宁夏自治区的基础医学研究中心学术委员会委员
陆军军医大学老年心脑血管病教育部重点实验室学术委员会委员
亚洲心脏协会 （AHS）转化和基础心血管科学委员会委员
上海市人工智能药物协会常务理事
第六届ISHR中国转化医学工作委员会委员

1. 心血管系统再生与重大疾病关键分子机制
2. 基因和细胞治疗新技术研发
3. 高通量测序技术研制和生物信息学软件及分析程序开发

1. Zhang Y, Liu XX, Hu Haiyan, Wang xiaoming, Zhang B, Gong lei. (2004) Inhibition of prostate cancer cell PC-3 by rAd-ODC/Ex3as. Journal of Shandong University, 42(5):423

2. Zhang B, Liu XX, Gong L. (2004) The development of antisense technology(review). Oncology Section Foreign Meidcal Sciences.31 (9):674

3. Zhang B, Liu XX, Zhang Y, et al. (2005) The screening of the sensitive antisense targets in the ODC mRNA. Chinese Journal of Current Advances in General Surgery, 8(5):146

4. Zhang B, Liu XX, Zhang Y, et al. (2005) Construction of an antisense bicistronic recombinant adenovirus vector of ODC and SAMDC. Journal of Shandong University, 43(5):345

5. Zhang Y, Liu XX, Zhang B, et al. (2005) inhibition of Prostate Cancer Cells with Antisense RNA of Ornithine Decarboxylase Gene in Vitro. Chinese Journal of Biochemistry and Molecular biology, 21(1): 128

6. Hu HY, Liu XX, Yi Lu, Shi-Lian Liu, Ji-Feng Bian, Xiao-Ming Wang, Zhao Geng, Yan Zhang, Zhang B (2005) Ornithine decarboxylase gene is overexpressed in colorectal carcinoma. World J Gastroenterol April; 11 (15):2244-2248

7. Zhang Y, Liu XX, Zhang B, Hu HY, Gong L. (2005) Antitumor effect of antisense ODC adenovirus on human prostate cancer cells. Prostate Cancer Prostatic Dis.;8(3):280-6

8. Zhang B, Liu XX, Zhang Y, Jiang CY, Hu HY, Gong L, Liu M, Teng QS. (2006) Polyamine depletion by ODC-AdoMetDC antisense adenovirus impairs human colorectal cancer growth and invasion in vitro and in vivo. J Gene Med. Aug;8(8):980-9.

9. Zhang B, Liu XX, Zhang Y, Jiang CY, Teng QS, Hu HY, Wang W, Gong L. (2006)Adenovirus-mediated expression of both antisense ODC and AdoMetDC inhibited colorectal cancer cell growth in vitro. Acta Pharmacol Sin. Mar;27(3):353-9

10. Gong L, Jiang C, Zhang B, Hu H, Wang W, Liu X. (2006) Adenovirus-mediated expression of both antisense ornithine decarboxylase and s-adenosylmethionine decarboxylase induces G1 arrest in HT-29 cells. J Biochem Mol Biol. Nov 30;39(6):730-6.

11. Gong L, Zhang B, Zhang Y, Hu H, Zhao Z, Liu X. (2007) Cloning, expression and purification of human S-adenosylmethionine decarboxylase gene alpha subunit. Chin J Physiol. Feb 28;50(1):29-33.

12. Tian H, Liu X, Zhang B, Sun Q, Sun D. (2007) Adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase inhibits lung cancer cell growth. Acta Biochim Biophys Sin (Shanghai). Jun;39(6):423-30.

13. Song X, Tian H, Liu XX, Zhang B, Li WJ, Xu J. (2008) Ornithine Decarboxylase and S-adenosylmethionine Decarboxylase Bi-antisense Virus Inhibit Growth and Invasion of Esophageal Cancer Cell Line Eca109. Ai Zheng. Nov;27(11):1144-9.

14. Zhang Bing, Ursula M. Dietrich, Jian-Guo Geng, Roy Bicknell, Jeffrey D.Esko and Lianchun Wang. (2009) Repulsive axon guidance molecule Slit3 is a novel angiogenic factor. Blood. 2009 Nov 5;114(19):4300-9. (IF>22)

15. Zhou B, Honor LB, He H, Ma Q, Oh JH, Butterfield C, Lin RZ, Melero-Martin JM, Dolmatova E, Duffy HS, Gise A, Zhou P, Hu YW, Wang G, Zhang B, Wang L, Hall JL, Moses MA, McGowan FX, Pu WT.Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J Clin Invest. 2011 May 2;121(5):1894-904. (IF>14)

16. He A, Ma Q, Cao J, von Gise A, Zhou P, Xie H, Zhang B, Hsing M, Christodoulou D, Cahan P, Daley GQ, Kong SW, Orkin SH, Seidman CE, Seidman JG, Pu WT. Polycomb Repressive Complex 2 Regulates Normal Development of the Mouse Heart. Circ Res. 2012 Feb 3;110(3):406-15. (IF>17)

17. Bing Zhang, Daniel S. Day, Joshua W. Ho, Lingyun Song, Jingjing Cao, Danos Christodoulou, Jonathan G. Seidman, Gregory E. Crawford, Peter J. Park, and William T. Pu. A dynamic H3K27ac signature defines VEGFA-regulated endothelial enhancers. Genome Res. 2013 Jun;23(6):917-27. (IF>10)

18. Zhang Bing, Pu WT. The mysterious origins of coronary vessels. Cell Res. 2013 Jul 9.doi:10.1038/cr. 2013.90. (IF>25)

19. Zhang Bing, Wenyuan Xiao, Hong Qiu, Fuming Zhang, Eduard Condac, Cathy Cheng, Parastoo Azadi, John J. Greer, Dean Li, kelley Moremen, Robert Linhardt, Jeffrey D. Esko, Lianchun Wang. Heparan sulfate deficiency disrupts developmental angiogenesis and causes congenital diaphragmatic hernia.J Clin Invest. 2014 Jan 2;124(1):209-21. (IF>14)

20. Zhang Bing, William. T. PU. Notching up vascular regeneration. Cell Research 2014; doi:10.1038/ cr.2014. (IF>25)

21. Ye Sun, Chi-Hsiu Liu, John Paul SanGiovannib, Lucy P. Evans, Katherine T. Tian, Bing Zhang, Andreas Stahld, William T. Pu, Theodore M. Kamenecka, Laura A. Solt, Jing Chen, Nuclear receptor RORα regulates pathologic retinal angiogenesis by modulating Socs3 dependent inflammation. PNAS. Proc Natl Acad Sci U S A. 2015 Aug 4. pii: 201504387. (IF>10)

22. Zhang Q, Qin J, Zhong L, Gong L, Zhang B, Zhang Y, Gao WQ. CCL5-mediated Th2 immune polarization promotes metastasis in luminal breast cancer. Cancer Res. 2015 Aug 6. pii: canres. 3590.2014. (IF>12)

23. Daniel Day, Zhang Bing*, Sean M. Stevens, Francesco Ferrari, Erica N. Larschan, Peter J Park*, William.T.PU*. Comphensive analysis of Promoter-Promximal RNA PolymeraseII Pasuing Across Mammlian Cell Types. Genome Biol. 2016 Jun 3;17(1):120. doi: 10.1186/s13059-016-0984-2. * co-first and co-corresponding author. (IF>13)

24. Guo H, Zhang B, Nairn AV, Nagy T, Moremen KW, Buckhaults P, Pierce M. O-GlcNAc expression levels epigenetically regulate colon cancer tumorigenesis by affecting the cancer stem cell compartment via modulating expression of transcriptional factor MYBL1. J Biol Chem. 2017 Jan 17. (IF>5)

25. Jiahuan Chen, Yi Fu, Daniel S. Day, Ye Sun, Shi-yan Wang, Xiaodong Liang, Fei Gu, Fang Zhang, Sean M. Stevens, Pingzhu Zhou, Kai Li, Yan Zhang, Ruei-zeng Lin, Lois E. H. Smith, Jin Zhang, Juan M. Melero-Martin, Ze-Guang Han, Peter J. Park, Bing Zhang*, William T. Pu* “VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis. Nat Commun. 2017 Aug 29;8(1):383. doi: 10.1038/s41467-017-00405-x. (IF>14)

26. 张冰， 傅怡 “Slit-ROBO信号通路在心血管发育中的作用。上海大学学报，Vol.22 No.3

27. Wenhua Yu, Fang Zhang, Huafeng Xie, Shiyan Wang, Yi Fu, Jiahuan Chen, Xiaodong Liang, Huangying Le, William T. Pu*, Bing Zhang*. Depletion of Polycomb Repressive Complex 2 core component EED impairs fetal hematopoiesis. Cell Death Dis. 2017 Apr 13;8(4):e2744. (IF>9)

28. Wang C, Chen J, Zhang Q, Li W, Zhang S, Xu Y, Wang F, Zhang B, Zhang Y, Gao WQ, Elimination of CD4lowHLA-G+ T cells overcomes castration-resistance in prostate cancer therapy, Cell Res., 2018 Oct 8. doi: 10.1038/s41422-018-0089-4. (IF>25)

29. Wang S, Chen J, Garcia SP, Liang X, Zhang F, Yan P, Yu H, Wei W, Li Z, Wang J, Le H, Han Z, Luo X, Day DS, Stevens SM, Zhang Y, Park PJ, Liu ZJ, Sun K, Yuan GC*, Pu WT*, Zhang B*. A dynamic and integrated epigenetic program at distal region orchestrates transcriptional responses to VEGFA. Genome Res. 2019 Feb;29(2):193-207. doi: 10.1101/gr.239053.118. (IF>10)

30. Akerberg BN, Gu F, VanDusen NJ, Zhang X, Dong R, Li K, Zhang B, Zhou B, Sethi I, Ma Q, Wasson L, Wen T, Liu J, Dong K, Conlon FL, Zhou J, Yuan GC, Zhou P, Pu WT. A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers. Nat Commun. 2019 Oct 28;10(1):4907. doi: 10.1038/s41467-019-12812-3. (IF>14)

31. Jiahuan Chen, Xiaodong Liang, Shasha Zhang, Shiyan Wang, Sara P. Garcia, Pengyi Yan, Huijing Yu, Zixuan Li, Li Liu, Fang Zhang, Weiting Wei, Huangying Le, Yan Zhang, Guo-cheng Yuan, Sun Chen, Yingwei Chen, Kun Sun, William T. Pu, Bing Zhang*,Two faces of bivalent domain regulate VEGFA responsiveness and angiogenesis. Cell Death Dis. 2020, Jan 30;11(1):75. (IF>9)

32. Fang Zhang, Pengyi Yan, Huijing Yu, Huangying Le, Zixuan Li, Jiahuan Chen, Xiaodong Liang, Shiyan Wang, Weiting Wei, Li Liu, Yan Zhang, Xing Ji, Anyong Xie, Wantao Chen, Zeguang Han, William T Pu, Sun Chen, Yingwei Chen, Kun Sun, Baoxue Ge, Bing Zhang*. LARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis. Cell Rep. 2020 Aug 18;32(7):108058. (IF>9)

33. Yifei Miao, Lei Tian, Marcy Martin, Sharon L Paige, Francisco X Galdos, Jibiao Li, Alyssa Klein, Hao Zhang, Ning Ma, Yuning Wei, Maria Stewart, Soah Lee, Jan-Renier Moonen, Bing Zhang, Paul Grossfeld, Seema Mital, David Chitayat, Joseph C Wu, Marlene Rabinovitch , Timothy J Nelson , Shuyi Nie, Sean M Wu, Mingxia Gu. Intrinsic Endocardial Defects Contribute to Hypoplastic Left Heart Syndrome. Cell Stem Cell. 2020 Oct 1;27(4):574-589.e8. (IF>24)

34. Huijing Yu; Fang Zhang; Pengyi Yan; Shasha Zhang; Yingmei Lou; Zilong Geng; Zixuan Li; Yan Zhang; Yuejuan Xu; Yanan Lu; Chen Chen; Daowen Wang; Wei Zhu; Xinyang Hu; Jian’an Wang; Tao Zhuang; Yuzhen Zhang; Gengze Wu; Junling Liu; Chunyu Zeng; William T. Pu; Kun Sun; Bing Zhang*, LARP7 protects against heart failure by enhancing mitochondrial biogenesis, Circulation 2021 May 18;143(20):2007-2022. (IF>29)

35. Xiaodong Liang, Shuo Wu, Zilong Geng, Li Liu, Shasha Zhang, Shiyan Wang, Yan Zhang, Yu Huang, Bing Zhang*, LARP7 suppresses endothelial-to-mesenchymal transition by coupling with TRIM28. Circulation Research, 2021 Sep 10.doi: 10.1161/CIRCRESAHA.121.319590. (IF>17)

36. Pengyi Yan, Zixuan li, Junhao Xiong, Zilong Geng, Weiting Wei, Yan Zhang, Gengze Wu, Tao Zhuang, Xiaoyu Tian, Zhijie Liu, Junling Liu, Kun Sun, Fengyuan Chen, Yuzhen Zhang, Chunyu Zeng, Yu Huang, Bing Zhang* LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity. Cell Rep. 2021 Nov 23;37(8):110038. (IF>9)

37. Li Liu,Zi-long Geng, Jia-huan Chen, Sha-sha Zhang, Bing Zhang*. Whole gene expression profile analysis of miRNAs in human umbilical vein endothelial cells regulated by vascular endothelial growth factor A. Journal of Shanghai Jiao Tong University (Medical Science) 2021, Vol. 41 ›› Issue (9): 1183-1189. doi: 10.3969/j.issn.1674-8115.2021.09.008

38. Xue Gong, Miao Tian, Nian Cao, Peili Yang, Zaicheng Xu, Shuo Zheng, Qiao Liao, Caiyu Chen, Cindy Zeng, Pedro A Jose, Da-Zhi Wang, Zhao Jian,Yingbin Xiao, Ding-Sheng Jiang, Xiang Wei , Bing Zhang, Yibin Wang, Ken Chen, Gengze Wu,Chunyu Zeng. Circular RNA circEsyt2 regulates vascular smooth muscle cell remodeling via splicing regulation. J Clin Invest. 2021 Dec 15;131(24):e147031. (IF>19)

39. Junyi Yu, Wei Wang, Jining Yang, Ye Zhang, Xue Gong, Hao Luo, Nian Cao, Zaicheng Xu, Miao Tian, Peili Yang, Qiao Mei, Zhi Chen, Zhuxin Li, Chuanwei Li, Xudong Duan, Qing Rex Lyu, Chen Gao, Bing Zhang, Yibin Wang, Gengze Wu, Chunyu Zeng. LncRNA PSR Regulates Vascular Remodeling Through Encoding a Novel Protein Arteridin.2022 Sep 22;101161CIRCRESAHA122321080. (IF>23)

40. Huan Hu, Zilong Geng, Shasha Zhang, Yuejuan Xu, Qingjie Wang, Sun Chen, Bing Zhang*, Kun Sun* and Yanan Lu*. Rare copy number variation analysis identifies disease-related variants in atrioventricular septal defect patients. Frontiers in Genetics. 03 February 2023, DOI 10.3389/fgene.2023.1075349 (IF>4)

41. Huan Hu, Jihong Huang, Shasha Zhang, Bing Zhang, Wenjuan Li, Kun Sun. Tumor necrosis factor‐α stimulation endothelial‐to‐mesenchymal transition during cardiac fibrosis via endothelin‐1 signaling. J Biochem Mol Toxicol. 2023;e23411. (IF>3)

42. Zilong Geng, Wenjuan Li, Ping Yang, Shasha Zhang, Shuo Wu, Junhao Xiong, Kun Sun, Dan Zhu, Sun Chen*,Bing Zhang*. Whole exome sequencing reveals genetic landscape associated with left ventricular outflow tract obstruction in Chinese Han population. Frontiers in Genetics, 2023. Dec （IF>4）

43. Shuo Wu, Ping Yang, Zilong Geng, Yige Li, Zhizhao Guo, Yingmei Lou, Shasha Zhang, Junhao Xiong, Huan Hu, Xiaoling Guo, William T. Pu, Yan Zhang, Dan Zhu, Bing Zhang*. Base editing effectively prevents early-onset severe cardiomyopathy in Mybpc3 mutant mice. Cell Res. 09 Feb. 2024, doi: 10.1038/s41422-024-00930-7 (IF>28)

44. Ping Yang, Yingmei Lou, Zilong Geng, Zhizhao Guo, Shuo Wu, Yige Li, Kaiyuan Song, Ting Shi, Shasha Zhang, Junhao Xiong, Alex F Chen, Dali Li, William T. Pu, Lintai Da, Yan Zhang*, Kun Sun*, Bing Zhang*.Allele-specific suppression of mutant MHC with a high precision RNA nuclease CRISPR-Cas13d prevents hypertrophic cardiomyopathy. Circulation, 2024 doi: 10.1161/CIRCULATIONAHA.123.067890.(IF>39)

45. Yang P, Wu S, Li Y, Lou Y, Xiong J, Wang Y, Geng Z, Zhang B*. LARP7 overexpression alleviates aortic senescence and atherosclerosis. J Cell Mol Med. 2024 Jun;28(11):e18388. (IF>4)

46. Lou Y,Yang P, Wang Y, Liu X, Guo Z, Geng Z, Lin J, Wang J, Zhang M, Guo X, Fu L, Zhu D, Wu L, Zhang B*.Long-term therapeutic efficacy and safety profiles of hpCas13d RNA editing in treating early-onset hypertrophic cardiomyopathy. Life Sci. 2024 Oct 17;358:123144. doi: 10.1016/j.lfs.2024.123144. Online ahead of print. (IF>5)

47. Peng JY, Fu X, Luo XY, Liu F,Zhang B, Zhou B, Sun K,Chen AF.Endothelial ELABELA improves post-ischemic angiogenesis by upregulating VEGFR2 expression.Transl Res. 2024 Aug;270:13-23. doi: 10.1016/j.trsl.2024.03.011. Epub 2024 Mar 2 (IF>6)

48. Clinical and Genetic Profile of Chinese Children With Danon Disease: A Single-Center Retrospective Cohort Study. Zhang Q, Chan W, Chen Y, Wu J, Chen H, Yu T, Yao R, Chen L,Zhang B, Zhang H, Zhang Z,Fu L.Can J Cardiol. 2024 Oct 11:S0828-282X(24)01018-3. doi: 10.1016/j.cjca.2024.10.005. Online ahead of print. (IF>3)

49. Sheng K, Ran Y, Feng X, Wang Y, Zhou S, Guan Y, Tan P, Qian S, Zhao Z, Zhang B, Ji W, Niu C,Guo X. PTN secreted by cardiac fibroblasts promotes myocardial fibrosis and inflammation of pressure overload-induced hypertrophic cardiomyopathy through the PTN-SDC4 pathway. Life Sci. 2025 Jan 5:123356. doi: 10.1016/j.lfs.2024.123356. (IF>5)

50. She P, Gao B, Li D, Wu C, Zhu X, He Y, Mo F, Qi Y, Jin D, Chen Y, Zhao X, Lin J, Hu H, Li J, Zhang B, Xie P, Lin C, Christoffels VM, Wu Y, Zhu P,Zhong TP.The transcriptional repressor HEY2 regulates mitochondrial oxidative respiration to maintain cardiac homeostasis. Nat Commun. 2025 Jan 2;16(1):232. doi: 10.1038/s41467-024-55557-4. (IF>14)

51. Zilong Geng, Yuze Wang, Tingting Liu, Ao Tan, Shuo Wu, Xiaoling Guo, Ruogu Li, Xumin Hou, Kun Sun, LianPin Wu, Qinghua Cui, Lintai Da, Zhiyuan Ma, Honglin Li, Bing Zhang. CHIEF: An Attention-based Ensemble Learning Framework for Functional Protein Design. bioRxiv, March 12, 2025, preprint doi: https://doi.org/10.1101/2025.03.07.641005

专著
《父母：孩子最好的健康管理师》， 2023年；编委

获得国家自然基金项目、科技部"重点研发专项”项目、上海市科委“上海世界顶尖科学家国际联合科学实验室项目"、上海市教委“重点创新项目”、“上海市高水平创新团队激励计划”、上海市科委“科技创新行动计划”、上海交通大学医工交叉重点项目等16项基金支持。

已授权专利
1. Wang L, Zhang B., Esko JD，Angiogenic protein and methods of use”Provisional U.S. Patent No: 61/053,295; . Issued July 2008.
2. 张冰、张芳，LARP7基因在癌症诊断和治疗中的应用，专利号 202010953449.5， 2020.11
3. 张冰、于蕙菁、闫鹏一、李紫璇，LARP7在心衰、动脉粥样硬化或衰老诊疗药物中的应用，专利号 ZL202010953449.5，2022.9

在申请专利四项， 国际PCT专利两项。

博士后1人
博士6人（硕博连读5人；致远荣誉计划2人；交大学术之星1人,交大学术之星优胜奖1人; 上海市优秀毕业生1人；国家奖学金1人，上海交大联新奖学金1人、上海交通大学优秀学生干部1人，上海交通大学校优秀党员1人，上海交通大学“三好学生”1人，北大医学博士论坛二等奖1人）
硕士2人 （上海交通大学“三好学生”1人）