师资队伍

吴强

讲席教授、博导

 

电话: 02134204300
传真: 02134204300
邮箱: qiangwu@@sjtu.edu.cn
主页: https://www.researchgate.net/profile/Qiang_Wu41

学习经历
1990年和1993年分别获得复旦大学学士和硕士。1998年获美国纽约州立大学石溪分校和冷泉港实验室细胞发育生物学博士。

 

工作经历
工作年份 ,职称
2020年,讲席教授
2018年,二级教授
2008年,特聘教授
2002年,助理教授,博导
在三维基因组编辑、调控和功能方面取得系统性研究成果。

 

人才奖项
上海交大系统生物医学研究院和癌基因及相关基因国家重点实验室研究员,比较生物医学研究中心主任,博士生导师。系统生物医学教育部重点实验室常务副主任,科技部重大科学研究计划(973)项目首席科学家,享受国务院政府特殊津贴,上海市优秀学术带头人。中国细胞学会表观遗传分会、中国生化分子生物学会基因分会和中国遗传学会基因编辑分会专业委员,中美生命科学家学会终身会员。曾经在复旦大学、纽约州立大学石溪分校和冷泉港实验室学习,哈佛大学、犹他大学和中科院生物物理所工作;曾获得上海市自然科学一等奖和高等学校科学研究优秀成果奖一等奖(均为第一完成人),上海交通大学教书育人奖,The Second Annual RNA Award, Damon Runyon Research Fellowship Award, American Cancer Society Research Scholar Award, Basil O’Connor Scholar Award等奖项。在分子遗传学和发育生物学相关三维基因组和基因编辑交叉领域取得一系列研究成果,相关论文发表于Cell, Science, Molecular Cell, PNAS, Genome Biology, NAR, Protein&Cell, Cell Research, Cell Discovery, eLife, Nature Genetics等学术杂志。现任上海交通大学系统生物医学教育部重点实验室常务副主任,中国神经科学学会,the Chinese Society for Neuroscience会员The Society for Neuroscience,正式会员,The RNA Society,会员。The American Association for the Advancement of Sciences,会员。The Sigma Xi Scientific Research Society,会员。The American Society of Human Genetics,会员。The Society of Chinese Bioscientists in America,终身会员。并为多个国际知名期刊审稿。

 

学会兼职与审稿人
中国细胞生物学会染色质专业委员会委员
中国生化分子生物学会基因专业委员会委员
中国遗传学会基因编辑专业委员会委员

We are interested in the regulation and function of the protocadherin and Ugt clusters during brain development as well as in brain diseases. To this end, we have developed novel methods of CRISPR DNA-fragment editing or chromosomal rearrangements to investigate mechanisms of three-dimensional (3D) genome folding. Finally, we are interested in the role of genome architectural protein CTCF in higher-order chromatin structure and its dynamic regulation.

Yuanxiao Tang, Zhilian Jia, Honglin Xu, Lin-tai Da, Qiang Wu. (2021). Mechanism of REST/NRSF Regulation of Clustered Protocadherin Alpha Genes. NAR in Press.

Wu Q. and Shou J. (2021). Toward precision CRISPR DNA fragment editing and predictable 3D genome engineering. Journal of Molecular Cell Biology, 12, 828-856.

Wu Q. and Jia Z. (2021). Wiring the brain by clustered protocadherin neural codes. Neurosci. Bull., 37, 117-131.

Jia, Z. and Wu, Q. (2020) Clustered Protocadherins Emerge as Novel Susceptibility Loci for Mental Disorders. Front Neurosci., 14, 587819.

Jia Z., Li J., Ge X., Wu Y., Guo Y., Wu Q. (2020). Tandem CTCF sites function as insulators to balance spatial chromatin contacts and topological enhancer-promoter selection. Genome Biology 21 (75), 1-24

Wu Q., Liu P. and Wang L. (2020). Many facades of CTCF unified by its coding for three dimensional genome architecture. Journal of Genetics and Genomics 47, 407-424.

Wu Y., Jia Z., Ge X., Wu Q. (2020). Three-dimensional genome architectural CCCTC-binding factor makes choice in duplicated enhancers at Pcdhα locus. SCIENCE CHINA Life Sciences, 63: 835-844.

Lu Y., Shou J., Jia Z., Wu Y., Li J., Guo Y., Wu Q. (2019). Genetic evidence for asymmetric blocking of higher-order chromatin structure by CTCF/cohesin. Protein & Cell 10 (12), 914-920

X Shi, J Shou, MM Mehryar, J Li, L Wang, M Zhang, H Huang, X Sun, Q Wu. (2019). Cas9 has no exonuclease activity resulting in staggered cleavage with overhangs and predictable di-and tri-nucleotide CRISPR insertions without template donor. Cell discovery 5 (1), 1-4

Shou J., Li J., Liu Y., Wu Q. (2018) Precise and predictable CRISPR chromosomal rearrangements reveal principles of Cas9-mediated nucleotide insertion. Molecular Cell. 71, 498-509. Epub 2018 Jul 19.

Fan L., Lu Y., Shen X., Shao H., Suo L., Wu Q. (2018) Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice. eLife. 7. pii: e35242. doi: 10.7554/eLife.35242. Highlighted in eLife Digest.

Xu D., Ma, R, Zhang, J, Liu Z., Wu B., Peng J., Zhai Y., Gong Q., Shi Y., Wu J., Wu Q., Zhang Z., Ruan K. (2018) Dynamic nature of CTCF tandem 11 Zinc fingers in multivalent recognition of DNA as revealed by NMR spectroscopy. J. Phys. Chem. Lett. 9: 4020-4028. doi: 10.1021/acs.jpclett.8b01440. Epub 2018 Jul 6.
Shen X.L., Lu Y.C., Jia Z.L., Wu Q. (2018) N-WASP regulates cortical neuron migration through its polyPro and VCA domains. Heriditas (Yi Chuan). 40: 390-401. doi: 10.16288/j.yczz.18-066.
Yin, M., Wang, J., Wang, M., Li, X., Zhang, M., Wu, Q., Wang, Y. (2017) Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites. Cell Research 27: 1365-1377.
Chen W.V., Nwakeze C.L., Denny C.A., O'Keeffe S., Rieger M.A., Mountoufaris G., Kirner A., Dougherty J.D., Hen R., Wu Q., Maniatis T. (2017) Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice. Science. 356: 406-411. doi: 10.1126/science.aal3231. Research Highlighted in Perspective in Science, 356: 376-378.
Chen, D., Zuo, Y., Zhang, X., Ye, Y., Bao, X., Huang, H., Tepakhan, W., Wang, L., Ju, J., Chen, G., Zheng, M., Liu, D., Huang, S., Zong, L., Li, C., Chen, Y., Zheng, C., Shi, L., Zhao, Q., Wu, Q., Fucharoen, S., Zhao, C., and Xu, X. (2017). A Genetic Variant Ameliorates beta-Thalassemia Severity by Epigenetic-Mediated Elevation of Human Fetal Hemoglobin Expression. Am J Hum Genet 101: 130-138.
Zhai Y., Xu Q., Guo Y., Wu Q. (2016). Characterizationof a cluster of CTCF-binding sites in a protocadherin regulatory region. Heriditas 38: 323-336.
Burgess, S., Cheng, L., Gu, F., Huang, J., Huang, Z., Lin, S., Li, J., Li, W., Qin, W., Sun, Y., Songyang, Z., Wei, W., Wu, Q., Wang, H., Wang, X., Xiong, J.W., Xi, J., Yang, H., Zhou, B., and Zhang, B. (2016). Questions about NgAgo. Protein & cell 7, 913-915.
Guo, Y., Q. Xu, D. Canzio, J. Shou, J. Li, D.U. Gorkin, I. Jung, H. Wu, Y. Zhai, Y. Tang, Y. Lu, Y. Wu, Z. Jia, W. Li, M.Q. Zhang, B. Ren, A.R. Krainer, T. Maniatis, Wu Q. (2015). CRISPR inversion of CTCF sites alters genome topology and enhancer/promoter function. Cell 162: 900-910. doi:10.1016/j.cell.2015.07.038. CELL Hottest Article.
Research Highlighted in Cell, 162, 703–705; Nature Reviews Molecular Cell Biology 16, 578–579.
Li J, Shou J,Guo Y, Tang Y, Wu Y, Jia Z, Zhai Y, Chen Z, Xu Q, Wu, Q. (2015). Efficient inversions and duplications of mammalian regulatory DNA elements and gene clusters by CRISPR/Cas9. J. Mol. Cell Biol. 7: 284-298. Cover Article.
Jia Z, Guo Y, Tang Y, Xu Q, Li B, Wu Q. (2014) Regulation of the protocadherin Celsr3 gene and its role in globus pallidus development and connectivity. Mol Cell Biol. 34: 3895-3910.
Wang Y., Huang H., Wu Q. (2014) Characterization of the zebrafish UGT repertoire reveals a new class of drug-metabolizing UDP glucuronosyltransferases. Mol. Pharmacol. 86: 62-75.
Guo Y., Monahan K., Wu H., Varley KE., Gertz J., Li W., Myers RM., Maniatis T., Wu Q. (2012) CTCF/Cohesin-mediated DNA Looping is required for protocadherin alpha promoter choice. Proc Natl Acad Sci USA 109: 21081-21086.
Suo L., Lu H., Ying G., Capecchi M.R., Wu, Q. (2012) Protocadherin clusters and cell adhesion kinase regulate dendrite complexity through Rho GTPase. J Mol Cell Biol 4: 362-376. Cover Article
Yang J., Cai L., Huang H., Liu B., Wu, Q. (2012) Genetic variations and haplotype diversity of the UGT1 gene cluster in the Chinese population. PLoS One 7: e33988.
Wu, Q. and Maniatis, T. (1999) A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell 97: 779-790.
Research highlighted in Cell, 98: 133–136; Neuron, 23: 427–430; Current Biology 9: R651–R654; Nature neuroscience 2: 686-687.
Wu, Q. and Krainer, A.R. (1996) U1-mediated exon definition interactions between AT-AC and GT-AG introns. Science 274: 1005-1008.

1. 原钙粘蛋白在脑发育和脑疾病中的生理病理功能
2. 三维基因组中染色质高级结构的编辑调控和功能

“检测原钙粘蛋白基因簇γ的方法及试剂盒”发明人:吴强,郭亚,汤元霄。申请号:201110359153。发明专利证书号:1279069。专利号:ZL2011 1 359153。授权公告日:2013.09.25

2009年,黄海燕,获国家博士后基金
2011年,汤元宵,获“三好学生”称号
2012年,吴海洋,获国家奖学金
2012年,郭亚,获博士研究生国家奖学金
2012年,甲芝莲,获博士研究生国家奖学金
2012年,郭亚,获上海交大博士生特别资助
2013年,郭亚,获Tony Leggett研究生一等奖学金
2013年,甲芝莲,获牛津奖学金
2014年,吴海洋,获教育部国家留学基金
2014年,甲芝莲,获Tony Leggett研究生二等奖学金
2014年,郭亚,获上海市优秀毕业生荣誉称号
2015年,李金环,获博士研究生国家奖学金
2015年,寿佳,获上海交大专项奖学金
2016年,许泉,获国家奖学金
2017年,刘沛峰,获博士新生最优秀奖学金
2017年,李金环,获第61批博士后基金
2018年,寿佳,获国际会议奖学金
2018年,李金环,获香港科技署博士后创新基金
2019年,寿佳,获联新奖学金
2019年,寿佳,获上海市优秀毕业生荣誉称号
2019年,寿佳,获上海交通大学优秀博士论文
2020年,寿佳,获上海市超级博士后
2020年,寿佳,获国家博士后创新人才激励计划
2019年,石欣,获联新奖学金
2019年,陈秀丽,获学业优秀一等奖学金
2020年,徐思远,获学业优秀一等奖学金
2021年,张颐骏,获学业优秀一等奖学金

吴强,甲芝莲 (2019) CTCF与三维基因组染色质高级结构 In Press in 《表观遗传学》
吴强,李伟 (2016) 第27章:从人类基因组到大脑发育:原钙粘蛋白在脑发育中的调控与功能研究 in 《前沿生命的启迪》461-477页,科学出版社 2016.9。
吴强,(2013) 教会学生做科研 in 《学者笔谈》第五辑280-289页,上海交通大学出版社 2013.1。

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