邹霞-上海交通大学系统生物医学研究院

学习经历
2007/09 - 2014/03，上海交通大学，生物化学与分子生物学，博士
2003/09 - 2007/06，南昌大学，生物技术，学士

工作经历
2021/01-至今，上海交通大学，系统生物医学研究院，副研究员
2016/06-2019/12，上海交通大学，系统生物医学研究院，助理研究员
2014/10-2015/02，日本产业技术综合研究所，联合培养博士后
2014/04-2016/05，上海交通大学医学院附属瑞金医院，博士后

人才奖项
上海市青年科技英才扬帆计划（2018年）

学会兼职与审稿人
中国生物化学与分子生物学会糖复合物专业委员会青年委员会委员
Carbohydrate Polymers 审稿人（IF：9.38）

疾病糖链生物标志物
功能糖组学及蛋白组学

第一/通讯作者：
1. Li, X., Xu, Z., Hong, X., Zhang, Y.*, and Zou, X.* Databases and Bioinformatic Tools for Glycobiology and Glycoproteomics. Int J Mol Sci. 2020;21(18).
2. Zou, X., Yao, F., Yang, F., Zhang, F., Xu, Z., Shi, J., Kuno, A., Zhao, H., and Zhang, Y. Glycomic Signatures of Plasma IgG Improve Preoperative Prediction of the Invasiveness of Small Lung Nodules. Molecules. 2019;25(1).
3. Xu, W. P. #, Wang, Z. R. #, Zou, X. #, Zhao, C., Wang, R., Shi, P. M., Yuan, Z. L., Yang, F., Zeng, X., Wang, P. Q., Sultan, S., Zhang, Y. *, and Xie, W. F. * Serum Wisteria floribunda agglutinin-positive Mac-2-binding protein evaluates liver function and predicts prognosis in liver cirrhosis. J Dig Dis. 2018;19(4):242-253.
4. Zou, X. #, Zhu, M. Y. #, Yu, D. M., Li, W., Zhang, D. H., Lu, F. J., Gong, Q. M., Liu, F., Jiang, J. H., Zheng, M. H., Kuno, A., Narimatsu, H., Zhang, Y. *, and Zhang, X. X. * Serum WFA(+) -M2BP levels for evaluation of early stages of liver fibrosis in patients with chronic hepatitis B virus infection. Liver Int. 2017;37(1):35-44.
5. Zou, X. #, Yoshida, M. #, Nagai-Okatani, C. #, Iwaki, J., Matsuda, A., Tan, B., Hagiwara, K., Sato, T., Itakura, Y., Noro, E., Kaji, H., Toyoda, M., Zhang, Y., Narimatsu, H., and Kuno, A. A standardized method for lectin microarray-based tissue glycome mapping. Sci Rep. 2017;7:43560.
6. Zhu, M. Y. #, Zou, X. #, Li, Q., Yu, D. M., Yang, Z. T., Huang, D., Chen, J., Gong, Q. M., Zhang, D. H., Zhang, Y., Chen, L., Chen, P. Z. *, and Zhang, X. X.* A novel noninvasive algorithm for the assessment of liver fibrosis in patients with chronic hepatitis B virus infection. J Viral Hepat. 2017;24(7):589-598.
7. Zou, X. #, Chi, X. #, Pan, Y., Du, D., Sun, H., Matsuda, A., Li, W., Kuno, A., Zhang, X., Narimatsu, H., Niu, J. *, and Zhang, Y. * LecT-Hepa facilitates estimating treatment outcome during interferon therapy in chronic hepatitis C patients. Clin Proteomics. 2014;11(1):44.
8. Zou, X.#, Feng, B.#, Dong, T., Yan, G., Tan, B., Shen, H., Huang, A., Zhang, X., Zhang, M., Yang, P., Zheng, M., and Zhang, Y. Up-regulation of type I collagen during tumorigenesis of colorectal cancer revealed by quantitative proteomic analysis. J Proteomics. 2013;94:473-485.

其它：
9. Jia, W., Zou, X., Xu, Z., Bai, L., Shan, A., Li, Y., Shi, J., Yang, F., Ding, C., Narimatsu, H., and Zhang, Y. Polypeptide N-acetylgalactosaminyltransferase 18 Retains in Endoplasmic Reticulum Depending on its Luminal Regions Interacting with ER resident UGGT1, PLOD3 and LPCAT1. Glycobiology. 2021. doi: 10.1093/glycob/cwab031.
10. Shi, J.#, Ku, X.#, Zou, X., Hou, J., Yan, W.*, and Zhang, Y.* Comprehensive Analysis of O-Glycosylation of Amyloid Precursor Protein (APP) Using Targeted and Multi-Fragmentation MS Strategy. Biochim Biophys Acta Gen Subj. 2021 (Accepted)
11. Nagai-Okatani, C., Zou, X., Fujita, N., Sogabe, I., Arakawa, K., Nagai, M., Angata, K., Zhang, Y., Aoki-Kinoshita, K. F., and Kuno, A. LM-GlycomeAtlas Ver. 2.0: An Integrated Visualization for Lectin Microarray-based Mouse Tissue Glycome Mapping Data with Lectin Histochemistry. J Proteome Res. 2021;20(4):2069-2075.
12. Xu, Z. #, Ku, X. #, Tomioka, A., Xie, W., Liang, T., Zou, X., Cui, Y., Sato, T., Kaji, H., Narimatsu, H., Yan, W., and Zhang, Y. O-linked N-acetylgalactosamine modification is present on the tumor suppressor p53. Biochim Biophys Acta Gen Subj. 2020;1864(8):129635.
13. Liang, T. #, Xu, Z. #, Jia, W., Zhang, H., Yang, F., Zou, X., and Zhang, Y. A simple bacterial expression system for human ppGalNAc-T and used for the synthesis of O-GalNAc glycosylated interleukin 2. Biochem Biophys Res Commun. 2020;529(1):57-63.
14. Zhou, L. #, Zhang, S. #, Zou, X., Lu, J., Yang, X., Xu, Z., Shan, A., Jia, W., Liu, F., Yan, X., Su, H., Liang, T., Zheng, M., Zhang, Y., and Feng, B. The beta-galactoside alpha2,6-sialyltranferase 1 (ST6GAL1) inhibits the colorectal cancer metastasis by stabilizing intercellular adhesion molecule-1 via sialylation. Cancer Manag Res. 2019;11:6185-6199.
15. Liu, T., Sun, Y., Zhou, J., Yang, F., Zou, X., Wang, L., Wu, X., Chen, Y., Piao, H., Lu, L., Jiang, W., Xu, Y., Feng, B., Nan, Y., Xie, W., Chen, G., Zheng, H., Li, H., Ding, H., Liu, H., Wang, T., Ou, X., Wu, S., Kong, Y., Wang, P., Cong, M., Zhang, Y., You, H., and Jia, J. On-treatment changes of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein are associated with the regression of liver fibrosis in chronic hepatitis B patients on interferon alpha add-on therapy. J Med Virol. 2019;91(8):1499-1509.
16. Yan, X. #, Lu, J. #, Zou, X., Zhang, S., Cui, Y., Zhou, L., Liu, F., Shan, A., Lu, J., Zheng, M., Feng, B., and Zhang, Y. The polypeptide N-acetylgalactosaminyltransferase 4 exhibits stage-dependent expression in colorectal cancer and affects tumorigenesis, invasion and differentiation. FEBS J. 2018;285(16):3041-3055.
17. Narimatsu, H., Kaji, H., Vakhrushev, S. Y., Clausen, H., Zhang, H., Noro, E., Togayachi, A., Nagai-Okatani, C., Kuno, A., Zou, X., Cheng, L., Tao, S. C., and Sun, Y. Current Technologies for Complex Glycoproteomics and Their Applications to Biology/Disease-Driven Glycoproteomics. J Proteome Res. 2018;17(12):4097-4112.
18. Zhang, S. #, Lu, J. #, Xu, Z., Zou, X., Sun, X., Xu, Y., Shan, A., Lu, J., Yan, X., Cui, Y., Yan, W., Du, Y., Gu, J., Zheng, M., Feng, B., and Zhang, Y. Differential expression of ST6GAL1 in the tumor progression of colorectal cancer. Biochem Biophys Res Commun. 2017;486(4):1090-1096.
19. Wang, Y., Cao, Y., Huang, X., Yu, T., Wei, Z., McGrath, J., Xu, F., Bi, Y., Li, X., Yang, F., Li, W., Zou, X., Peng, Z., Xiao, Y., Zhang, Y., He, L., and He, G. Allele-specific expression of mutated in colorectal cancer (MCC) gene and alternative susceptibility to colorectal cancer in schizophrenia. Sci Rep. 2016;6:26688.
20. Tan, B., Qiu, Y., Zou, X., Chen, T., Xie, G., Cheng, Y., Dong, T., Zhao, L., Feng, B., Hu, X., Xu, L. X., Zhao, A., Zhang, M., Cai, G., Cai, S., Zhou, Z., Zheng, M., Zhang, Y., and Jia, W. Metabonomics identifies serum metabolite markers of colorectal cancer. J Proteome Res. 2013;12(6):3000-3009.
21. Cheng, Y., Xie, G., Chen, T., Qiu, Y., Zou, X., Zheng, M., Tan, B., Feng, B., Dong, T., He, P., Zhao, L., Zhao, A., Xu, L. X., Zhang, Y., and Jia, W. Distinct urinary metabolic profile of human colorectal cancer. J Proteome Res. 2012;11(2):1354-1363.
22. Wang, S., Xie, W., Zhang, X., Zou, X., and Zhang, Y. Disulfide- and terminal alkyne-functionalized magnetic silica particles for enrichment of azido glycopeptides. Chem Commun (Camb). 2012;48(47):5907-5909.
23. Peng, C., Togayachi, A., Kwon, Y. D., Xie, C., Wu, G., Zou, X., Sato, T., Ito, H., Tachibana, K., Kubota, T., Noce, T., Narimatsu, H., and Zhang, Y. Identification of a novel human UDP-GalNAc transferase with unique catalytic activity and expression profile. Biochem Biophys Res Commun. 2010;402(4):680-686.

1. 国家自然科学基金青年项目，2019-2021，主持
2. 上海市青年科技英才扬帆计划，2018-2021，主持
3. 上海交通大学医工交叉基金项目，2017，2018，2021（两项），合作主持
4. 中国博士后科学基金一等资助，2014-2016，主持

1. 邹霞，张延，杨芳，冯波，郑民华，CTx在制备诊断结直肠癌药物中的用途，2015.9.23，中国，ZL 2013 1 0476530.9
2. 张延，彭灿，武功冬，邹霞，谢文娴，ppGalNAc-T20抗原及其多克隆抗体的制备方法，2011.7.22，中国，ZL201010300097.X
3. 张延，张芳，许之珏，杨芳，邹霞，姚烽，赵珩，血清免疫球蛋白G糖链修饰在肺部磨玻璃结节早期诊断中的用途，2017.11.4，中国，ZL201711070938.0