Including learning experience
2003.09-2009.07 Fudan University/Chinese Human Genome Center at Shanghai, PhD in Genetics, Shanghai, China
1998.09-2002.07 Hubei University, Bachelor of Science in Biology, Wuhan, China

 

Work Experience
2020.10-Now, Tenure-track Associated Professor/Principal Investigator, Shanghai Jiao Tong University, Shanghai Center for Systems Biomedicine, Shanghai, China
2014.09-2020.09 Postdoctoral Research Associate, Memorial Sloan Kettering Cancer Center [MSKCC], New York, USA
2009.07-2014.08 Postdoctoral Research Fellow, University of Michigan/Howard Hughes Medical Institute, Ann Arbor, Michigan, USA

 

Talent Awards
1. Sponsored by the Talent Program of Shanghai Municipality in 2021
2. Sponsored by the Talent Program of Shanghai Jiao Tong University in 2020
3. Selected as 1 of 10 Remarkable Basic Science Breakthroughs of MSKCC in 2019, New York, USA
4. Granted The Society of Memorial Sloan-Kettering Scholars Prize in 2018, New York, USA

 

Social Service
AAAS Membership, NYAS Membership, Reviewer of the journals: Aging, J Cancer, Int J Biol Sci

DNA damage repair and telomere biology
1. Mechanistic studies of the association of DNA damage response protein and human tumorigenesis
2. Mechanistic studies of the role of DNA damage response protein in genome maintenance of yeast
3. Telomere Maintenance of telomere-binding proteins and its roles in cancer and aging

1. Ma Y, Huang C, Tang T, Wu B, Xue H, Cao Y, Wu J, Wan B* and Lei M*. Structural and functional insights into CST tethering in Tetrahymena thermophila telomerase, Structure, 2022, 30(12): 1563-1564. (* corresponding author) .
2. Yu Y, Li S, Ser Z, Sanyal T, Choi K, Wan B, Kuang H, Sali A, Kentsis A, Patel DJ, Zhao X. Integrative analysis reveals unique structural and functional features of the Smc5/6 complex. Proc Natl Acad Sci U S A, 2021, 118(19):e2026844118. PMID: 33941673.
3. Li S, Bonner JN, Wan B, So S, Summers A, Gonzalez L, Xue X, Zhao X. Esc2 orchestrates substrate-specific sumoylation by acting as a SUMO E2 cofactor in genome maintenance. Genes Dev. 2021, 35(3-4): 261-272. PMID: 33446573
4. Wan B, Wu J, Meng X, Lei M, Zhao X. Molecular basis for control of diverse genome stability factors by the multi-BRCT scaffold Rtt107. Mol Cell. 2019, 75(2):238-251. PMID: 31348879.
5. Shultis D., Mitra P., Huang X., Johnson J., Khattak N.A., Gray F., Piper C., Czajka J., Hansen L., Wan B., Chinnaswamy K., Liu L., Wang M., Pan J., Stuckey J., Cierpicki T., Borchers C.H., Wang S., Lei M., Zhang Y. Changing the Apoptosis Pathway through Evolutionary Protein Design. J Mol Biol. 2019, 431(4):825-841. PMID: 30625288.
6. Bonner JN, Choi K, Xue X, Torres NP, Szakal B, Wei L, Wan B, Arter M, Matos J, Sung P, Brown GW, Branzei D, Zhao X. Smc5/6 mediated sumoylation of the Sgs1-Top3-Rmi1 complex promotes removal of recombination intermediates. Cell Rep. 2016,16(2):368-378. PMID: 27373152.
7. Yin J#, Wan B#, Sarkar J#, Horvath K, Wu J, Chen Y, Cheng G, Wan K, Chin P, Lei M*, Liu Y*. Dimerization of SLX4 contributes to functioning of the SLX4-nuclease complex. Nucl Acids Res. 2016,44(10):4871-4880. PMID: 27131364 (* equal contribution)
8. Wan B, Hang L, Zhao X. Multi-BRCT scaffolds use distinct strategies to support genome maintenance. Cell Cycle. 2016,15(19):2561-2570. PMID: 27580271.
9. Wan B#, Tang T#, Upton H, Shuai J, Zhou Y, Li S, Chen J, Brunzelle JS, Zeng Z, Collins K, Wu J*, Lei M*. The Tetrahymena telomerase p75-p45-p19 subcomplex is a unique CST complex. Nat Struct Mol Biol. 2015,22(12):1023-1026. PMID: 26551074. (* equal contribution)
10. Sarkar J, Wan B, Yin J, Vallabhaneni H, Horvath K, Kulikowicz T, Bohr VA, Zhang Y, Lei M, Liu Y. SLX4 contributes to telomere preservation and regulated processing of telomeric joint molecule intermediates. Nucl Acids Res. 2015,43(12):5912-5923. PMID: 25990736.
11. Yang YW, Flynn RA, Chen Y, Qu K, Wan B, Wang KC, Lei M, Chang HY. Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency. Elife. 2014, 3:e02046. PMID: 24521543.
12. Sommers JA, Banerjee T, Hinds T, Wan B, Wold MS, Lei M and Brosh RM. Novel function of the fanconi anemia group J or RECQ1 helicase to disrupt protein-DNA complexes in a replication protein a-stimulated manner. J Biol Chem. 2014,289(29):19928-19941. PMID: 24895130.
13. Wan B#, Yin J#, Horvath K#, Sarkar J, Chen Y, Wu J, Wan K, Lu J, Gu P, Yu EY, Lue NF, Chang S, Liu Y*, Lei M*. SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres. Cell Rep. 2013,4(5):861-869. PMID: 24012755. (* equal contribution)
14. Zhou J, Wan B, Shan J, Shi H, Li Y, Huo K. PTPN4 negatively regulates CrkI in human cell lines. Cell Mol Biol Lett. 2013,18(2):297-314. PMID: 23666597.
15. Huang J, Gurung B*, Wan B*, Matkar S, Veniaminova NA, Wan K, Merchant JL, Hua X, Lei M. The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature 2012,482(7386):542-546. PMID: 22327296. (* equal contribution)
16. Chen Y, Cao F, Wan B, Dou Y, Lei M. Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30. Cell Res. 2012,22(3):598-602. PMID: 22231628.
17. Huang J, Wan B, Wu L, Yang Y, Dou Y, Lei M. Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex. Cell Res. 2012,22(6):1078-1081. PMID: 22547026.
18. Chen Y*, Wan B*, Wang KC*, Cao F, Yang Y, Protacio A, Dou Y, Chang HY, Lei M. Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding. EMBO Rep. 2011,12(8):797-803. PMID: 21660059. (* equal contribution)
19. Xu X, Liu RF, Wan BB, Xing WM, Huang J, Han ZG. Expression of a novel gene FAM43B repressing cell proliferation is regulated by DNA methylation in hepatocellular carcinoma cell lines. Mol Cell Biochem. 2011,354(1-2):11-20. PMID: 21461611.
20. Huang J, Zheng DL, Qin FS, Cheng N, Chen H, Wan BB, Wang YP, Xiao HS, Han ZG. Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling. J Clin Invest. 2010,120(1):223-241. PMID: 20038795.
21. Wan B, Wang XR, Zhou YB, Zhang X, Huo K, Han ZG. C12ORF39, a novel secreted protein with a typical amidation processing signal. Biosci Rep. 2010,30(1):1-10. PMID: 19193193.
22. Li T, Wan B, Huang J. Comparison of gene expression in hepatocellular carcinoma, liver development and liver regeneration. Mol Genet Genomics. 2010,283(5):485-492. PMID: 20358383.
23. Wan B, Zhou YB, Zhang X, Zhu H, Huo K, Han ZG. hOLFML1, a novel secreted glycoprotein, enhances the proliferation of human cancer cell lines in vitro. FEBS Lett. 2008,582(21-22):3185-3192. PMID: 18708057.
24. Zhou YB*, Cao JB*, Wan BB*, Wang XR, Ding GH, Zhu H, Yang HM, Wang KS, Zhang X, Han ZG. hBolA, novel non-classical secreted proteins, belonging to different BolA family with functional divergence. Mol Cell Biochem. 2008,317(1-2):61-68. PMID: 18548201. (* equal contribution)
25. Li L, Shi Y, Wu H, Wan B, Li P, Zhou L, Shi H, Huo K. Hepatocellular carcinoma-associated gene 2 interacts with MAD2L2. Mol Cell Biochem. 2007,304(1-2):297-304. PMID: 17541814.

1. 2022.04-2025.03 Science and Technology Commission of Shanghai Municipality：22ZR1432700 (Telomere research)，PI
2. 2022.01-2025.12 National Natural Science Foundation of China (NSFC): 32170087 (DNA damage repair research)，PI
3. 2021.07-2023.07 National Facility for Translational Medicine (Shanghai), China: TMSK-2021-132 (DNA damage repair research)，PI

Postdoc: Hongjin Qu
PhD students: Yu Cao, Liming Hu
Master degree students: Yang Luo, Sisi Yang.
Lab Alumni: Junshi Li, Yifei Huang.