Including learning experience
2009-2014 PhD Aarhus University, Denmark
2006-2009 Master Chinese Academy of Sciences
2002-2006 Bachelor Shandong University

 

Work Experience
2017.11-current. Principal investigator, Shanghai Jiaotong University
2014.01-2017.10 postdoc Aarhus University

 

 

1. Develop the delivery tool for CRISPR solving the ‘last mile problem’ for its application in gene therapy.
2. Develop next-gen lentivirus and apply it in gene therapy of important genetic diseases such as beta-thalassemia.
3.Combine gene editing and immune editing strategy to develop new oncolytic virus.
4. Apply CRISPR screening tool to systematically investigate virus and host interactions.

1. Di Yin, Sikai Ling, Dawei Wang, Yao Dai, Hao Jiang, Xujiao Zhou, Soren Riis Paludan, Jiaxu Hong*, and Yujia Cai*. Intracorneal delivery of HSV-targeting CRISPR/Cas9 mRNA cures herpetic stromal keratitis. Nature Biotechnology. 2021.
2. Sikai Ling, Shiqi Yang, Xinde Hu, Di Yin, Yao Dai, Xiaoqing Qian, Dawei Wang, Xiaoyong Pan, Jiaxu Hong, Xiaodong Sun, Hui Yang, Soren Riis Paludan and Yujia Cai* (2020). Hit-and-run knockout of vegfa by lentiviral nanoparticle-delivered Cas9 mRNA prevents wet age-related macular degeneration. Nature Biomedical Engineering. 2021.
3. An overview of development in gene therapeutics in China. Gene therapy; 1-11. Wang, D., K. Wang and Y. Cai*. 2020

1. Two China National Invention Patent on CRISPR Delivery Technology
2. One PCT Patent

Yao Dai (Master, East China Normal University) Ph.D. candidate
Yiye Zhong (Master, Zhejiang University) Ph.D. candidate
Zhuofan Jiang (Master, University of Nottingham) Ph.D. student
Shuhui Zhang (Bachelor, Xi’an Jiaotong University) Master’s student
Sicong Lu (Bachelor, The University of Sydney) Master’s student
Yu Guo (Bachelor) Master’s student
Luoni Zhang (Bachelor) Master’s student
Ziyuan Xia (Bachelor) Master’s student
Jie Wang Joint Ph.D. student, Shanghai Jiao Tong University School of Medicine
Qihao Tang (Bachelor’s student, Shanghai Jiaotong University) Student Intern
Xiaoyuan Wang (Bachelor, Shanghai Ocean University) Visiting student

Graduate Student:
Sikai Ling (Master, Shandong University) Ph.D. graduate
Di Yin (Master, Zhejiang University) Ph.D. graduate, Postdoctoral researcher of Stanford University