Including learning experience
1993 –1996 Doctor of Biotechnology, Tokyo University, Japan
1991 –1993 Master of Biotechnology, Tokyo University, Japan
1982 –1986 Bachelor of Microbiology, Shan Dong University, China

 

Work Experience
2006 – present Professor/PI ,Shanghai Jiao Tong University, China
Director of SCSB(China)-AIST(Japan) Joint Medical Glycomics Laboratory
2004 –2006 Research associate, National Institute of Animal Health ,Japan
2001 –2004 Research associate, Research Center for Medical Glycoscience , AIST, Japan
1996 –2001 Postdoctoral Fellow, National Institute of Advanced Industrial Science and Technology (AIST)
1986 –1989 Research associate, Shanghai Jiao Tong University, China

 

Talent Awards
2018 March 8th Redbanner pacesetter，Shanghai Jiao Tong University
(a honorific title for woman who have extraodinary achievements and outstanding contributions)
2007 Shanghai Pujiang Talents，Science and Technology Commission of Shanghai Municipality
(a honorific title for outstanding talents who returned from abroad)

 

Social Service
1. Deputy Director , Committee of glycoconjugate, The Chinese Society of Biochemistry and Molecular Biology
2. Standing Committee member, Committee of Glycoengineering , Chinese Society of Biotechnology
3. Executive Director, Committee of Glycobiology, Biophysical Society of China
4. Standing Committee member, Committee of Carbohydrate Chemistry, Chinese Chemical Society
5. Committee member, Committee of China Human Proteome Organization, The Chinese Society of Biochemistry and Molecular Biology
6. Member, The Society for Glycobiology(SFG)
7. Member, Asian Community of Glycoscience and Glycotechnology (ACGG)
8. Committee member, Academic Committee of Key laboratory of Carbohydrate and Biotechnology (Jiangnan University), Ministry of Education, China
9. Committee member, Academic degree committee of Division of Life Sciences, Shanghai Jiao Tong University, China

1. Functional studies of glycotransferases, protein glycosylation
2. Glycoproteomics and glycobiomarker discovery
3. Human glycoprotein engineering

1. Book: Chiaki Nagai-Okatani , Xia Zou , Atsushi Matsuda , Yoko Itakura , Masashi Toyoda , Yan Zhang , Atsushi Kuno. Tissue Glycome Mapping: Lectin Microarray-Based Differential Glycomic Analysis of Formalin-Fixed Paraffin-Embedded Tissue Sections. In: Kilcoyne, M., Gerlach, J.Q. (eds) Glycan Microarrays. Methods in Molecular Biology, vol 2460. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2148-6_10
2. Zou, X., Lu J., Deng Y., Liu Q., Yan X., Cui Y., Xiao X., Fang M., Yang F., Sawaki H., Sato T., Tan B., Lu X., Feng B., Kuno A., Narimatsu H., Gao C., Zhang Y.* ST6GAL1 inhibits metastasis of hepatocellular carcinoma via modulating sialylation of MCAM on cell surface. Oncogene. 2022; Accept
3. 史婧婧; 邹霞; 张延*, 淀粉样前体蛋白糖基化修饰对其加工剪切的调控. 生物技术 2022, 32 (01), 90-98+78.
4. 张涵; 张延*, 糖蛋白药物的生产与糖链改造. 上海交通大学学报 2021, 55 (S1), 41-43.
5. 邓陶; 刘倩楠; 邹霞; 张延*, 基于末端糖链的疾病诊疗新技术. 上海交通大学学报 2021, 55 (S1), 44-45.
6. Shi, J.; Ku, X.; Zou, X.; Hou, J.; Yan, W.*; Zhang, Y.*, Comprehensive analysis of O-glycosylation of amyloid precursor protein (APP) using targeted and multi-fragmentation MS strategy. Biochim Biophys Acta Gen Subj 2021, 1865 (10), 129954.
7. Nagai-Okatani, C.*; Zou, X.; Fujita, N.; Sogabe, I.; Arakawa, K.; Nagai, M.; Angata, K.; Zhang, Y.; Aoki-Kinoshita, K. F.; Kuno, A. *, LM-GlycomeAtlas Ver. 2.0: An Integrated Visualization for Lectin Microarray-based Mouse Tissue Glycome Mapping Data with Lectin Histochemistry. J Proteome Res 2021, 20 (4), 2069-2075.
8. Jia, W.; Zou, X.; Xu, Z.; Bai, L.; Shan, A.; Li, Y.; Shi, J.; Yang, F.; Ding, C.; Narimatsu, H.; Zhang, Y.*, Polypeptide N-acetylgalactosaminyltransferase 18 Retains in Endoplasmic Reticulum Depending on its Luminal Regions Interacting with ER resident UGGT1, PLOD3 and LPCAT1. Glycobiology 2021.
9. Xu, Z.; Ku, X.; Tomioka, A.; Xie, W.; Liang, T.; Zou, X.; Cui, Y.; Sato, T.; Kaji, H.; Narimatsu, H.; Yan, W.; Zhang, Y.*, O-linked N-acetylgalactosamine modification is present on the tumor suppressor p53. Biochim Biophys Acta Gen Subj 2020, 1864 (8), 129635.
10. Liang, T.; Xu, Z.; Jia, W.; Zhang, H.; Yang, F.; Zou, X.; Zhang, Y.*, A simple bacterial expression system for human ppGalNAc-T and used for the synthesis of O-GalNAc glycosylated interleukin 2. Biochem Biophys Res Commun 2020, 529 (1), 57-63.
11. Li, X.; Xu, Z.; Hong, X.; Zhang, Y.*; Zou, X.*, Databases and Bioinformatic Tools for Glycobiology and Glycoproteomics. Int J Mol Sci 2020, 21 (18).
12. Zou, X.; Yao, F.; Yang, F.; Zhang, F.; Xu, Z.; Shi, J.; Kuno, A.; Zhao, H.; Zhang, Y.*, Glycomic Signatures of Plasma IgG Improve Preoperative Prediction of the Invasiveness of Small Lung Nodules. Molecules 2019, 25 (1).
13. Zhou, L.; Zhang, S.; Zou, X.; Lu, J.; Yang, X.; Xu, Z.; Shan, A.; Jia, W.; Liu, F.; Yan, X.; Su, H.; Liang, T.; Zheng, M.; Zhang, Y.*; Feng, B.*, The beta-galactoside alpha2,6-sialyltranferase 1 (ST6GAL1) inhibits the colorectal cancer metastasis by stabilizing intercellular adhesion molecule-1 via sialylation. Cancer Manag Res 2019, 11, 6185-6199.
14. Zhang, S.; Bai, L.; Chen, Q.; Ren, Y.; Zhang, K.; Wu, Q.; Huang, H.; Li, W.; Zhang, Y.*; Zhang, J.*; Liu, Y.*, Identification of the O-GalNAcylation site(s) on FOXA1 catalyzed by ppGalNAc-T2 enzyme in vitro. Biochem Biophys Res Commun 2019, 514 (1), 157-165.
15. Tian, J. Q.; Liu, F.; Xu, Z. J.; Shi, J. J.; Liang, T.; Zhang, Y.*; Da, L. T.*, Regulatory Role of One Critical Catalytic Loop of Polypeptide N-Acetyl-Galactosaminyltransferase-2 in Substrate Binding and Catalysis during Mucin-Type O-Glycosylation. Acs Catal 2019, 9 (11), 10536-10550.
16. Shan, A. D.; Lu, J. S.; Xu, Z. J.; Li, X.; Xu, Y. J.; Li, W.; Liu, F.; Yang, F.; Sato, T.; Narimatsu, H.*; Zhang, Y.*, Polypeptide N-acetylgalactosaminyltransferase 18 non-catalytically regulates the ER homeostasis and O-glycosylation. Biochim Biophys Acta Gen Subj 2019, 1863 (5), 870-882.
17. Liu, F.; Cui, Y.; Yang, F.; Xu, Z.; Da, L. T.; Zhang, Y.*, Inhibition of polypeptide N-acetyl-alpha-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis. Bioorg Med Chem 2019, 27 (15), 3372-3382.
18. Liu, T., Sun, Y., Zhou, J., Yang, F., Zou, X., Wang, L., Wu, X., Chen, Y., Piao, H., Lu, L., Jiang, W., Xu, Y., Feng, B., Nan, Y., Xie, W., Chen, G., Zheng, H., Li, H., Ding, H., Liu, H., Wang, T., Ou, X., Wu, S., Kong, Y., Wang, P., Cong, M., Zhang, Y., You, H.*, and Jia, J.* On-treatment changes of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein are associated with the regression of liver fibrosis in chronic hepatitis B patients on interferon alpha add-on therapy. J Med Virol. 2019;91(8):1499-1509.
19. Shan, A. D., Lu, J. S., Xu, Z. J., Li, X.; Xu, Y. J., Li, W., Liu, F., Yang, F., Sato,T., Narimatsu, H. *, Zhang, Y.* Polypeptide N-acetylgalactosaminyltransferase 18 non-catalytically regulates the ER homeostasis and O-glycosylation. BBA-General Subjects 2019, ,1863(5),870-882
20. Yan, X. L., Lu, J. S., Zou, X., Zhang, S., Cui, Y. L., Zhou, L. Q., Liu, F., Shan, A. D., Lu, J. Y., Zheng, M. H., Feng, B.*, Zhang, Y.* The polypeptide N-acetylgalactosaminyltransferase 4 exhibits stage-dependent expression in colorectal cancer and affects tumorigenesis, invasion and differentiation. Febs J 2018, 285, 3041-3055.
21. Xu, W. P.; Wang, Z. R.; Zou, X.; Zhao, C.; Wang, R.; Shi, P. M.; Yuan, Z. L.; Yang, F.; Zeng, X.; Wang, P. Q.; Sultan, S.; Zhang, Y.*; Xie, W. F.*, Serum Wisteria floribunda agglutinin-positive Mac-2-binding protein evaluates liver function and predicts prognosis in liver cirrhosis. J Dig Dis 2018, doi: 10.1111/1751-2980.12596. 
22. Zhu, M. Y.; Chen, P. Z.; Li, J.; Yu, D. M.; Huang, D.; Zhu, X. J.; Han, Y.; Chen, J.; Huang, W.; Chen, Y. Y.; Gong, Q. M.; Jiang, J. H.; Zhang, D. H.; Zhang, Y.; Zhang, J. M.; Zhang, X. X., Serum M2BPGi level is a novel predictive biomarker for the responses to pegylated interferon-alpha treatment in HBeAg-positive chronic hepatitis B patients. J Medical Virol 2018, 90(4), 721-729.
23. 崔雅璐; 徐颖姣; 贾文娟; 杨芳; 张延*, 疾病及发育中多肽:N-乙酰氨基半乳糖转移酶ppGalNAc-T的重要性. 生命科学 2018, 30(11): 1264-1274
24. Liu, F.; Xu, K.; Xu, Z. J.; de las Rivas, M.; Wang, C. R.; Li, X.; Lu, J. S.; Zhou, Y. Y.; Delso, I.; Merino, P.; Hurtado-Guerrero, R.*; Zhang, Y.*; Wu, F.*, The small molecule luteolin inhibits N-acetyl--galactosaminyltransferases and reduces mucin-type O-glycosylation of amyloid precursor protein. J Biol Chem 2017, 292(52), 21304-21319.
25. Xu, Z. J.; Li, X.; Zhou, S. M.; Xie, W. X.; Wang, J.; Cheng, L.; Wang, S.; Guo, S. J.; Xu, Z. W.; Cao, X.; Zhang, M. H.; Yu, B. A.; Narimatsu, H.; Tao, S. C.*; Zhang, Y.*, Systematic identification of the protein substrates of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T1/T2/T3 using a human proteome microarray. Proteomics 2017, 17, (11).
26. 张芳; 许之珏; 徐颖姣; 邹霞; 张延*, IgG糖基化与疾病相关性研究进展. 生命科学 2017, 04, 319-330.
27. Zhang, S.; Lu, J.; Xu, Z.; Zou, X.; Sun, X.; Xu, Y.; Shan, A.; Lu, J.; Yan, X.; Cui, Y.; Yan, W.; Du, Y.; Gu, J.; Zheng, M.; Feng, B.*; Zhang, Y.*, Differential expression of ST6GAL1 in the tumor progression of colorectal cancer. Biochem Biophys Res Commun 2017, 486(4), 1090-1096.
28. Zou, X.; Zhu, M. Y.; Yu, D. M.; Li, W.; Zhang, D. H.; Lu, F. J.; Gong, Q. M.; Liu, F.; Jiang, J. H.; Zheng, M. H.; Kuno, A.; Narimatsu, H.; Zhang, Y.*; Zhang, X. X.*, Serum WFA+-M2BP levels for evaluation of early stages of liver fibrosis in patients with chronic hepatitis B virus infection. Liver Int 2017, 37(1), 35-44.
29. Zou, X.; Yoshida, M.; Nagai-Okatani, C.; Iwaki, J.; Matsuda, A.; Tan, B.; Hagiwara, K.; Sato, T.; Itakura, Y.; Noro, E.; Kaji, H.; Toyoda, M.; Zhang, Y.; Narimatsu, H.; Kuno, A., A standardized method for lectin microarray-based tissue glycome mapping. Sci Rep 2017, 7, 43560.
30. Xu, Y.; Pang, W.; Lu, J.; Shan, A.; Zhang, Y.*, Polypeptide N-Acetylgalactosaminy ltransferase 13 Contributes to Neurogenesis via Stabilizing the Mucin-type O-Glycoprotein Podoplanin. J Biol Chem 2016, 291(45), 23477-23488.
31. Zou, X.; Chi, X.; Pan, Y.; Du, D.; Sun, H.; Matsuda, A.; Li, W.; Kuno, A.; Zhang, X.; Narimatsu, H.; Niu, J.*; Zhang, Y.*, LecT-Hepa facilitates estimating treatment outcome during interferon therapy in chronic hepatitis C patients. Clin Proteomics 2014, 11(1), 44.
32. Tan, B.; Matsuda, A.; Zhang, Y.; Kuno, A.; Narimatsu, H., Multilectin-assisted fractionation for improved single-dot tissue glycome profiling in clinical glycoproteomics. Mol Biosyst 2014, 10 (2), 201-205.
33. Yu, D. M.; Li, X. H.; Mom, V.; Lu, Z. H.; Liao, X. W.; Han, Y.; Pichoud, C.; Gong, Q. M.; Zhang, D. H.; Zhang, Y.; Deny, P.; Zoulim, F.; Zhang, X. X., N-glycosylation mutations within hepatitis B virus surface major hydrophilic region contribute mostly to immune escape. J Hepatol 2014, 60(3), 515-522.
34. Zhang, X.; Zhang, Y.*, Applications of Azide-Based Bioorthogonal Click Chemistry in Glycobiology. Molecules 2013, 18(6), 7145-7159.
35. Zou, X.; Feng, B.; Dong, T. T.; Yan, G. Q.; Tan, B. B.; Shen, H.; Huang, A.; Zhang, X.; Zhang, M. H.; Yang, P. Y.; Zheng, M. H.; Zhang, Y.*, Up-regulation of type I collagen during tumorigenesis of colorectal cancer revealed by quantitative proteomic analysis. J Proteomics 2013, 94, 473-485.
36. Tan, B. B.; Qiu, Y. P.; Zou, X.; Chen, T. L.; Xie, G. X.; Cheng, Y.; Dong, T. T.; Zhao, L. J.; Feng, B.; Hu, X. F.; Xu, L. X.; Zhao, A. H.; Zhang, M. H.; Cai, G. X.; Cai, S. J.; Zhou, Z. X.; Zheng, M. H.; Zhang, Y.*; Jia, W.*, Metabonomics Identifies Serum Metabolite Markers of Colorectal Cancer. J Proteome Res 2013, 12(6), 3000-3009.
37. Aoki-Kinoshita, K. F.; Sawaki, H.; An, H. J.; Campbell, M.; Cao, Q. C.; Cummings, R.; Hsu, D. K.; Kato, M.; Kawasaki, T.; Khoo, K. H.; Kim, J.; Kolarich, D.; Li, X. Y.; Liu, M. Q.; Matsubara, M.; Okuda, S.; Packer, N. H.; Ranzinger, R.; Shen, H. L.; Shikanai, T.; Shinmachi, D.; Toukach, P.; Yamada, I.; Yamaguchi, Y.; Yang, P. Y.; Ying, W. T.; Yoo, J. S.; Zhang, Y.; Zhang, Y.; Narimatsu, H., The Fifth ACGG-DB Meeting Report: Towards an International Glycan Structure Repository. Glycobiology 2013, 23(12), 1422-1424.
38. Li, X.; Wang, J.; Li, W.; Xu, Y. J.; Shao, D.; Xie, Y. Y.; Xie, W. X.; Kubota, T.; Narimatsu, H.; Zhang, Y*., Characterization of ppGalNAc-T18, a member of the vertebrate-specific Y subfamily of UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalacto saminyltransferases. Glycobiology 2012, 22(5), 602-615.
39. Wang, S.; Xie, W. X.; Zhang, X.; Zou, X.; Zhang, Y.*, Disulfide- and terminal alkyne-functionalized magnetic silica particles for enrichment of azido glycopeptides. Chem Commun (Camb) 2012, 48(47), 5907-5909.
40. Du, D. N.; Zhu, X. J.; Kuno, A.; Matsuda, A.; Tsuruno, C.; Yu, D. M.; Zhang, Y.; Ikehara, Y.; Tanaka, Y.; Zhang, X. X.; Narimatsu, H., Comparison of LecT-Hepa and FibroScan for assessment of liver fibrosis in hepatitis B virus infected patients with different ALT levels. Clin Chim Acta 2012, 413(21-22), 1796-1799.
41. 王静; 彭灿; 张延*, O-糖基化起始糖基转移酶的活性与结构研究. 生命科学 2011, 07, 619-629.
42. Peng, C.; Togayachi, A.; Kwon, Y. D.; Xie, C. Y.; Wu, G. D.; Zou, X.; Sato, T.; Ito, H.; Tachibana, K.; Kubota, T.; Noce, T.; Narimatsu, H.; Zhang, Y.*, Identification of a novel human UDP-GalNAc transferase with unique catalytic activity and expression profile. Biochem Biophys Res Commun 2010, 402(4), 680-686.
43. Wang, S.; Zou, X.; Zhang, Y.*, Mass Spectrometry Based Analysis of Protein O-glycosylation. Prog Chem 2010, 22(12), 2428-2435.
44. Cheng, L. M.; Tachibana, K.; Iwasaki, H.; Kameyama, A.; Zhang, Y.; Kubota, T.; Hiruma, T.; Tachibana, K.; Kudo, T.; Guo, J. M.; Narimatsu, H., Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T15. FEBS Lett 2004, 566(1-3), 17-24.
45. Zhang, Y.; Iwasaki, H.; Wang, H.; Kudo, T.; Kalka, T. B.; Hennet, T.; Kubota, T.; Cheng, L. M.; Inaba, N.; Gotoh, M.; Togayachi, A.; Guo, J. M.; Hisatomi, H.; Nakajima, K.; Nishihara, S.; Nakamura, M.; Marth, J. D.; Narimatsu, H., Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine : polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen. J Biol Chem 2003, 278(1), 573-584.
46. Wang, H.; Tachibana, K.; Zhang, Y.; Iwasaki, H.; Kameyama, A.; Cheng, L. M.; Guo, J. M.; Hiruma, T.; Togayachi, A.; Kudo, T.; Kikuchi, N.; Narimatsu, H., Cloning and characterization of a novel UDP-GaINAc : polypeptide N-acetylgalactosaminyl transferase, pp-GaINAc-T14. Biochem Biophys Res Commun 2003, 300(3), 738-744.
47. Iwasaki, H.; Zhang, Y.; Tachibana, K.; Gotoh, M.; Kikuchi, N.; Kwon, Y. D.; Togayachi, A.; Kudo, T.; Kubota, T.; Narimatsu, H., Initiation of O-glycan synthesis in IgA1 hinge region is determined by a single enzyme, UDP-N-acetyl- alpha-D- galactosamine: Polypeptide N-acetylgalactosaminyltransferase 2. J Biol Chem 2003, 278(8), 5613-5621.
48. Guo, P.; Zhang, Y.; Zhang, X. Y.; Chen, H. L.; Zhang, Y.; Wang, H.; Narimatsu, H., Analysis of lewis antigens on cell surface and alpha1,3 fucosyltransferase subtypes in H7721 human hepatocarcinoma cells. J Exp Clin Cancer Res 2003, 22(1), 135-139.
49. Kudo, T.; Iwai, T.; Kubota, T.; Iwasaki, H.; Takayma, Y.; Hiruma, T.; Inaba, N.; Zhang, Y.; Gotoh, M.; Togayachi, A.; Narimatsu, H., Molecular cloning and characterization of a novel UDP-Gal : GaINAc alpha peptide beta 1,3-galactosyltransferase (ClGal-T2), an enzyme synthesizing a core 1 structure of O-glycan. J Biol Chem 2002, 277(49), 47724-47731.
50. Iwai, T.; Inaba, N.; Naundorf, A.; Zhang, Y.; Gotoh, M.; Iwasaki, H.; Kudo, T.; Togayachi, A.; Ishizuka, Y.; Nakanishi, H.; Narimatsu, H., Molecular cloning and characterization of a novel UDP-GlcNAc: GalNAc-peptide,beta 1,3-N-acetylgluco- saminyltransferase (beta 3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycans. J Biol Chem 2002, 277(15), 12802-12809.
51. Guo, J. M.; Zhang, Y.; Cheng, L. M.; Iwasaki, H.; Wang, H.; Kubota, T.; Tachibana, K.; Narimatsu, H., Molecular cloning and characterization of a novel member of the UDP-GalNAc : polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc- T12. FEBS Lett 2002, 524(1-3), 211-218.
52. Gotoh, M.; Sato T.; Akashima T.; Iwasaki H, Kameyama A, Mochizuki H, Yada T, Inaba N, Zhang Y.; Kikuchi N.; Kwon YD, Togayachi A, Kudo T, Nishihara S, Watanabe H.; Kimata K.; Narimatsu, H., Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesis. J Biol Chem 2002, 277(41), 38189-38196.
53. Cheng, L. M.; Tachibana, K.; Zhang, Y.; Guo, J.; Tachibana, K. K.; Kameyama, A.; Wang, H.; Hiruma, T.; Iwasaki, H.; Togayachi, A.; Kudo, T.; Narimatsu, H., Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T10. FEBS Lett 2002, 531(2), 115-121.
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73. Shen, J.; Zhang, B. R.; Wei, G. F.; Pang, X.; Wei, H.; Li, M.; Zhang, Y.; Jia, W.; Zhao, L. P., Molecular profiling of the Clostridium leptum subgroup in human fecal microflora by PCR-denaturing gradient gel electrophoresis and clone library analysis. Appl Environl Microbiol 2006, 72(8), 5232-5238.
74. Hagiwara, H.; Kunihiro, S.; Nakajima, K.; Sano, M.; Masaki, H.; Yamamoto, M.; Pak, J. W.; Zhang, Y.; Takase, K.; Kuwabara, I.; Maruyama, I. N.; Machida, M., Affinity selection of DNA-binding proteins from yeast genomic DNA libraries by improved lambda phage display vector. J Biochem 2002, 132(6), 975-982.
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78. Kimura T., Zhang, Y., Kodama, T., Omori T., Isolation and characterization of Tn 5-induced mutants deficient in carbazole catabolism. FEMS Microbiol Lett 1996, 135, 65-70.
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1. National Natural Science Foundation of China Project, The mechanism of ppGalNAc-T18 regulating the maturation and secretion of O-glycoylated protein in cells, 2021/01-2024/12, PI.
2. National Natural Science Foundation of China Project, Functional Study of a Neural-specific O-GalNAc Glycosyltransferase in Mouse, 2018/01-2021/12, PI.
3. Ministry of Science and Technology of China, The National Science and Technology Major Project of China, Development and Clinical Application of Novel Lectin Recognition Technology for Abnormal Glycoproteins in Hepatitis B-related Hepatocellular Carcinoma, 2018/1-2020/12, PI
4. National Natural Science Foundation of China Project, Research on the Molecular Mechanism of Inhibitor of Protein O-GalNAc Glycosylation, 2016/1-2019/12, PI.
5. Interdisciplinary Project of Science and Technology Innovation Foundation of Shanghai Jiao Tong University, Discovery of Plasma Glycobiomarker for Small Pulmonary Ground-Glass Nodules, 2016/1-2018/12, PI.
6. National Natural Science Foundation of China Project, The Essential Role of ppGalNAc-T18 in Endoplasmic Reticulum, 2014/1-2017/12, PI.
7. Ministry of Science and Technology of China, The International Science & Technology Cooperation Program of China, A Novel Technology based on the Glyobiomarker for Early Diagnosis of Disease, 2012/6-2015/5, PI.
8. The Shanghai International Science & Technology Cooperation Program of China, A Novel Technology based on the Glycobiomarker for Early Diagnosis of Disease, 2012/10-2014/9, PI.
9. Ministry of Science and Technology of China, The National Basic Research Program of China/973 project, Research on the Function and Molecular Mechanism of Glycans in Biological Behavior of Cancer Cells, 2012/1-2016/8, PI.
10. Ministry of Science and Technology of China,The National High Technology Research and Development Program of China/863 project, Development of Lectin microarray and Verification of Glycan structure, 2012/1-2015/12, PI
11. National Natural Science Foundation of China Project, Functional Study of the Novel O-GalNAc Glycosylation on Cytoplasmic Protein, 2012/1-2015/12, PI.
12. National Natural Science Foundation of China Project, Functional Study of ppGalNAc-T13 During the Process of Neural Differentiation in P19 Cells, 2010/1-2012/12, PI
13. National Natural Science Foundation of China Project, Functional Study of ppGalNAc-T in Lung Cancer, 2008/1-2010/12, PI.
14. Ministry of Science and Technology of China,The National Basic Research Program of China/973-project, Proteomics Study and its Correlation With Metabolome in Disease and Drug Treatment, 2007/7-2011/8, PI
15. Shanghai Pujiang Talents Program, Functional Study of Polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-T) in Tumorigenesis, 2007/10-2009/9, PI.

1. Yan Zhang, Han Zhang, Zhijue Xu, Fang Yang. Prokaryotic expression system for mucin type o-glycosylated protein, and preparation method of mucin type o-glycosylated protein. P.R.C. Patent No.CN202111031228.3. (Pending)
2. Yan Zhang, Tao Liang, Zhijue Xu, Wenjuan Jia. Method for preparing N-acetyl-galactose aminotransferase, P.R.C. Patent No. ZL201911267015.3. (Granted)
3. Yan Zhang, Fang Zhang, Zhijue Xu, Fang Yang, Xia Zou, Feng Yao, Heng Zhao. Application of Serum IgG Glycosylation in Early Diagnosis of Small Pulmonary Ground-Glass Nodules, P.R.C. Patent No. ZL201711070938.0(Granted)
4. Xia Zou, Yan Zhang, Fang Yang, Bo Feng, Minhua Zheng. Application of CTx in The Drug Discovery for The Diagnosis of Colorectal Cancer, P.R.C. Patent No. ZL201310476530.9 (Granted)
5. Yan Zhang, Sheng Wang, Wenxian Xie. The Synthesis and Application of Magnetic Nanoparticles Enriching Azido Labelled Biomacromolecules. P.R.C. Patent No. ZL201110236722.3 (Granted)
6. Yan Zhang, Wenjie Pang. The Synthesis and Application of a Specific Antigen Peptide for PPGalNAc-T13 Polyclonal Antibody. P.R.C. Patent No. ZL201110236821.1 (Granted)
7. Yan Zhang, Can Peng, Gongdong Wu, Xia Zou, Wenxian Xie. Preparation of ppGalNAc-T20 Antigen and Its Polyclonal Antibody. P.R.C. Patent No. ZL201010300097.X (Granted)
8. Hisashi Narimatsu, Yan Zhang. Mutant of N-acetylgalactosaminotransferase. JPN. Patent No. 4251402 (Granted)

1. Academic Supervisions
PhD students: 4
Master students: 3
PhD. Graduates: 7 (Graduated with PhD Degree)
Certificate of Graduation for PhD course: 2
Master Graduates: 11 (Graduated with MS Degree)
Postdoctors: 3
2. Students’ Honors & Awards
Three PhD. Graduates awarded the National Scholarship for Doctoral Students of China (2013/2016/2018)
Three PhD. Graduates awarded the Outstanding Graduate of Shanghai Jiao Tong University (2014/2017/2019)
One PhD. student awarded the Outstanding Graduate of Shanghai Municipality (2017)