Including learning experience
2005-2010 Ph.D. in Physical Chemistry with Prof. Yun-Dong Wu, Peking University
2001-2005 B.Sc in Chemistry, Inner Mongolia University

 

Work Experience
2017.1-now Shanghai Jiao Tong University
2015.11-2016.12 Visiting scholar in Beijing Computational Science Research Center
2014.05-2015.11 Postdoctoral with Prof. Huan-Xiang Zhou in Florida State University
2013.09-2014.05 Postdoctoral with Prof. Xuhui Huang in Chemistry Department, HKUST
2013.03-2013.09 Visiting scholar in University of California, San Diego
2010-2013.02 Postdoctoral with Prof. Xuhui Huang in Chemistry Department, HKUST

 

Talent Awards
2017, Pujiang Talents Project

 

1. Computational Investigations on Target-site Searching and Recognition Mechanism by DNA-binding Proteins.
2. Mechanistic Investigations on the Membrane Fusion between Virus and Host Cells.
3. Development and Applications of Useful Enzymatic Tools.

1. Lingyan Wang, Kun Xi, Lizhe Zhu*, Lin-Tai Da*. DNA Deformation Exerted by Regulatory DNA-Binding Motifs in Human Alkyladenine DNA Glycosylase Promotes Base Flipping. J. Chem. Inf. Model. 2022, 62: 3213-3226.
2. Lingyan Wang, Kaiyuan Song, Lin-Tai Da*. Computational investigations on target-site searching and recognition mechanisms by thymine DNA glycosylase during DNA repair process.  Acta. Biochim. Biophys. Sin. 2022, 54: 796-806.
3. Honglin Xu, Kaiyuan Song, Lin-Tai Da*. Dynamics of peptide loading into major histocompatibility complex class I molecules chaperoned by TAPBPR. Phys. Chem. Chem. Phys. 2022, 24: 12397-12409.
4. Mengna Lin, Honglin Xu, Yi Shi*, Lin-Tai Da*. Antigenic Peptide Loading into Major Histocompatibility Complex Class I Is Driven by the Substrate N-Terminus. CCS Chemistry 2021, 3: 979-994.
5. Jiaqi Tian, Lingyan, Wang, Lin-Tai Da*. Atomic resolution of short-range sliding dynamics of thymine DNA glycosylase along DNA minor-groove for lesion recognition. Nucleic Acids Research 2021, 49: 1278-1293.
6. Yi Shi*, Mingxuan Zhang, Luming Meng*, Xianbin Su, Xueying Shang, Zehua Guo, Qingjiao Li, Mengna Lin, Xin Zou, Qing Luo, Yaoliang Yu, Yanting Wu, Lin-Tai Da*, Tom Weidong Cai*, Guang He* & Ze-Guang Han*. A novel neoantigen discovery approach based on chromatin high order conformation. BMC Med. Genomics 2020, 27: 62.
7. Yi Shi, Zehua Guo, Xianbin Su, Luming Meng, Mingxuan Zhang, Jing Sun, Chao Wu, Minhua Zheng, Xueyin Shang, Xin Zou, Wangqiu Cheng, Yaoliang Yu, Yujia Cai, Chaoyi Zhang, Weidong Cai, Lin-Tai Da*, Guang He*, Ze-Guang Han*. DeepAntigen: A Novel Method for Neoantigen Prioritization via 3D Genome and Deep Sparse Learning. Bioinformatics 2020, btaa596.
8. Shuang Li, Lin-Tai Da*. Key Structural Motifs in Thymine DNA Glycosylase Responsible for Recognizing Certain DNA Bent Conformation Revealed by Atomic Simulations. Biochemical and Biophysical Research Communications 2020, 526: 953-959.
9. Mengna Lin, Lin-Tai Da*. Refolding Dynamics of gp41 from Pre-fusion to Pre-hairpin States During HIV-1 Entry. J. Chem. Inf. Model. 2020, 60: 162-174. 
10. Jiaqi Tian#, Feng Liu#, Jingjing Shi, Zhijue Xu, Yan Zhang*, Lin-Tai Da*. Regulatory Role of One Critical Catalytic Loop of Polypeptide N-Acetyl-Galactosaminyltransferase-2 in Substrate Binding and Catalysis during Mucin-Type O-Glycosylation. ACS Catalysis 2019, 9: 10536-10550.
11. Lin-Tai Da*, Mengna Lin. Opening dynamics of HIV-1 gp120 upon receptor binding is dictated by a key hydrophobic core. Phys. Chem. Chem. Phys. 2019, 21: 26003-26016.
12. Jingyi Weng, Xuliang Bu, Beibei He, Zhuo Cheng, Jun Xu, Lin-Tai Da*, Minjuan Xu*. Rational Engineering of Amide Synthetase Enables Bioconversion to Diverse Xiamenmycin Derivatives, Chemical Communications 2019, 55: 14840-14843.
13. Shuangyan Zhou, Danfeng Shi, Xuewei Liu, Xiaojun Yao, Lin-Tai Da*, Huanxiang Liu*. pH-Induced Misfolding Mechanism of Prion Protein: Insights from Microsecond-Accelerated Molecular Dynamics Simulations. ACS Chemical Neuroscience 2019, 10: 2718-2729.
14. Hai Liu, Lin-Tai Da*, Yuan Liu*. Understanding the molecular mechanism of umami recognition by T1R1-T1R3 using molecular dynamics simulations. Biochemical and Biophysical Research Communications 2019, 514: 967-973.
15. Lin-Tai Da*, Jin Yu Base-Flipping Dynamics from an Intrahelical to an Extrahelical State Exerted by Thymine DNA Glycosylase During DNA Repair Process. Nucleic Acids Research 2018, 46: 5410-5425.
16. Lin-Tai Da*, Yi Shi, Guodong Ning, Jin Yu*. Dynamics of the Excised Base Release in Thymine DNA Glycosylase during DNA Repair Process. Nucleic Acids Research 2018, 46: 568-581.
17. Lin-Tai Da*, Chao E, Yao Shuai, Shaogui Wu, Xiao-Dong Su, and Jin Yu*. T7 RNA polymerase translocation is facilitated by a helix opening on the fingers domain that may also prevent backtracking. Nucleic Acids Research 2017, 45: 7909-7921.

Current research funding includes National Natural Science Foundation of China, Ministry of Science and Technology of Shanghai, and the Shanghai Pujiang Talents.

I had supervised 4 graduate students from biological majors, three of them completed their MS programs (by 2020, 2021, and 2022), and one completed with PhD (by 2021). The one finished PhD in 2021 won “Outstanding graduate student scholarship” of the year and “SJTU Outstanding graduate student” based on her PhD work. She continues her academic career now in university. The one finished MS in 2021 won “National scholarship” of the year and “SJTU Outstanding graduate student”. Currently, I have recruited 3 PhD students and 3 MS students into my lab. One MS student, Kaiyuan Song, won “National scholarship” in 2022, and PhD student, Lingyan Wang, won SJTU “Three goods” student in 2022 and “Ziyuan scholarship”. Moreover, I have taken charge of one PhD class for two years, during which weekly seminars were held to encourage the communications and discussions between students with different academic backgrounds.