课题组长:严威
课题组成员
工作人员:库鑫 张灿
主要研究方向
1. 疾病蛋白质组学
2. 质谱分析的临床应用
3. 癌症诊断蛋白质生物标志物研发蛋白质组学
代表性成果
1. Wei Yan, Brenda Schilke, Chris Pfund, William Walter, Suwon Kim and Elizabeth A. Craig (1998) “Zuo1, a ribosome-associated DnaJ molecular chaperone” EMBO Journal 17: 4809-4817
2. Wei Yan, Christopher L. Frank, Marcus J. Korth, Bryce L. Sopher, Isabel Novoa, David Ron, and Michael G. Katze (2002) “Control of PERK eIF-2 kinase activity by the ER stress-induced molecular chaperone P58IPK” Proceedings of the National Academy of Sciences USA 99:15920-15925 (track II article, corresponding author)
3. Wei Yan, Hookeun Lee, Eugene YI, Paul Shannon, David Reiss, Bartlomiej Kwieciszewski, Xiao-Jun Li, Andrew Keller, Jimmy Eng, Tim Galitski, David Goodlett, Ruedi Aebersold, and Michael Katze (2004) “System-based proteomic analysis of the interferon response in human liver cells” Genome Biology 5 (8): R54. (corresponding author, highly accessed article)
4. Wei Yan, Jie Luo, Max Robinson, Jimmy Eng, Ruedi Aebersold, Jeffrey Ranish* (2011) “Index-ion triggered MS2 Ion Quantification: A Novel Proteomics Approach for Reproducible Quantification of Targeted Proteins in Complex Mixtures” Molecular and Cellular Proteomics, 10(3):M110.005611, (co-first and co-corresponding author)
5. Ting Xue, Ping Liu,Yong Zhou, Kun Liu, Li Yang, Robert Moritz, Wei Yan, Lisa X.Xu (2016) "Interleukin-6 Induced “Acute” Phenotypic Microenvironment Promotes Th1 Anti-Tumor Immunity In Cryo-Thermal Therapy Revealed By Shotgun And Parallel Reaction Monitoring Proteomics” Theranostics 6(6): 773-794 (co-corresponding author)
6. Chandrababu Rejeeth , Xuechao Pang , Ru Zhang, Wei Xu, Xuming Sun, Bin Liu, Jiatao Lou, Jingjing Wan, Hongchen Gu, Wei Yan, and Kun Qian (2018) “Extraction, detection, and profiling of serum biomarkers using designed Fe3O4@SiO2@HA core–shell particles” Nano Research 11(1): 68-79, DOI 10.1007/s12274‐017‐1591‐6 (co-corresponding author)