本课题组是一个非常年轻的研究团队，聚焦肿瘤信号通路研究，特别是泛素化修饰调控异常在肿瘤中的作用及机制。从临床样本、动物模型、细胞水平等多层次对肿瘤特别是胃癌中的关键蛋白的泛素化修饰调控及功能进行研究，寻找胃癌靶向治疗的新靶点。
课题组成员
学生：博士：傅旭宏
主要研究方向
1. 泛素化修饰异常（ubiquitination）与肿瘤的发生发展
2. 胃印戒细胞癌（signet-ring cell carcinoma）的发病机制
代表性成果
1. Huang LY#,*, Zhao J#, Chen H, Wan L, Inuzuka H, Guo J, Wang X, Han ZG, Sun Y*, Wei W*. SCFFBW7-mediated Degradation of Brg1 Suppresses Gastric Cancer Metastasis. Nat Commun. 2018 Sep 3; 9(1):3569. (#第一作者，*通讯作者)
2. Wan L†, Xu K†, Wei Y†, Zhang J†, Han T, Fry C, Zhang Z, Wang V, Huang LY, Xia W, Chang WC, Huang WC, Liu CL, Chang YC, Wu Y, Liu J, Jin VX, Li J, Dai X, Guo J, Liu J, Asara JM, Brown M, Huang MC, Wei W. Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function. Mol Cell. 2018 Jan 18; 69 (2): 219-291.
3. Huang LY#, Wang X#, Cui XF#, Li H, Zhao J, Wu CC, Min L, Zhou Z, Wan L, Wang YP, Zhang C, Gao WQ, Sun Y, Han ZG. IRTKS is correlated with progression and survival time of gastric cancer patients. Gut. 2017 Jun 24. doi: 10.1136/gutjnl-2016-313478. (#第一作者)
4. Xia P, Wang S, Xiong Z, Ye B, Huang LY, Han ZG, Fan Z. IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation. Nat Commun. 2015 Sep 8;6:8132. doi: 10.1038/ncomms9132
Huang LY#, Wang YP#, Wei BF, Yang J, Wang JQ, Wu BH, Zhang ZZ, Hou YY, Sun WM, Hu RM, Ning G, Han ZG. Deficiency of IRTKS as an adaptor of insulin receptor leads to insulin resistance. Cell Res. 2013 Jul 30. doi: 10.1038/cr.2013.99. (#第一作者)
