学习经历
2003.09-2007.06 华中科技大学同济医学院，药学，学士
2007.09-2010.07 中国科学院上海药物研究所，药物发现，硕士
2010.10-2014.06 德国慕尼黑工业大学，肿瘤蛋白质组学，博士
工作经历
2021-至今 上海交通大学系统生物医学研究院 副研究员
2015-2020 上海交通大学系统生物医学研究院 助理研究员
2014-2015 苏黎世联邦理工大学 博士后
人才奖项
2016年度上海市科技英才扬帆计划
学会兼职与审稿人
Scientific Report审稿人
蛋白质组学 肿瘤药理学 生物标志物
21. Zhou Z, Lu Y, Gu Z, Sun Q, Fang W, Yan W, Ku X*, Liang Z*, Hu G*. HNRNPA2B1 as a potential therapeutic target for thymic epithelial tumor recurrence: An integrative network analysis. Comput. Biol. Med. 2023 Mar;155:106665 (*Corresponding author)
20. Xin Ku, Jinghan Wang, Haikuo Li, Chen Meng, Fang Yu, Wenjuan Yu, Zhongqi Li, Ziqi Zhou, Can Zhang, Ying Hua, Wei Yan & Jie Jin. Proteomic Portrait of Human Lymphoma Reveals Protein Molecular Fingerprint of Disease Specific Subtypes and Progression. Phenomics. 2022.
19. Fei Zhu; Sijie Yang; Fanwang Meng; Yuxiang Zheng; Xin Ku; Cheng Luo; Guang Hu; Zhongjie Liang. Leveraging Protein Dynamics to Identify Functional Phosphorylation Sites using Deep Learning Models. Journal of Chemical Information and Modeling. 2022 Jul 25;62(14):3331-3345
18. Severin Lechner, Martin Ian P. Malgapo, Christian Grätz, Raphael R. Steimbach, Agnes Baron, Patrick Rüther, Simon Nadal, Carmen Stumpf, Christina Loos, Xin Ku, Polina Prokofeva, Ludwig Lautenbacher, Tino Heimburg, Vivian Würf, Chen Meng, Mathias Wilhelm, Wolfgang Sippl, Karin Kleigrewe, Josch K. Pauling, Karl Kramer, Aubry K. Miller, Michael W. Pfaffl, Maurine E. Linder, Bernhard Kuster & Guillaume Médard. Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target. Nature Chemical Biology. 2022 April 28.
17. Jingjing Shi*, Xin Ku*, Xia Zou, Jingli Hou, Wei Yan, Yan Zhang. Comprehensive analysis of O-glycosylation of amyloid precursor protein (APP) using targeted and multi-fragmentation MS strategy. BBA-General Subject. 2021 Jul; 1865(10):129954 (*Co-first author)
16. Zhijue Xu, Xin Ku, Azusa Tomioka, Wenxian Xie, Tao Liang, Xia Zou, Yalu Cui, Takashi Sato, Hiroyuki Kaji, Hisashi Narimatsu, Wei Yan, Yan Zhang. O-linked N-acetylgalactosamine modification is present on the tumor suppressor p53. BBA-General Subject. 2020 Aug;1864(8):129635.
15. Minghui Chen, Tingxiang Yan, Liyun Ji, Dong Yu, Simone Sidoli, Zuofei Yuan, Chunlin Cai, Jiwei Chen, Yueli Tang, Qian Shen, Qifang Pan, Xueqing Fu, Ku Xin, Lujian liao, Benjamin A. Garcia, Wei Yan and Kexuan Tang. Comprehensive map of the Artemisia annua proteome and quantification of differential protein expression in chemotypes producing high vs low content of artemisinin. Proteomics. 2020 May;20(10):e1900310.
14. Xin Ku*, Chunlin Cai, Yan Xu, Su Chen, Zhenhua Zhou, Jianru Xiao and Wei Yan. Data Independent Acquisition-Mass Spectrometry (DIA-MS)-based Comprehensive Profiling of Bone Metastatic Cancers Revealed Molecular Fingerprints to Assist Clinical Classifications for Bone Metastasis of Unknown Primary (BMUP). Translational Cancer Research. 2020;9(4):2390-2401. (* corresponding author)
13. Xin Ku*, Qiangling Sun*, Lei Zhu, Zhitao Gu, Yuchen Han, Ning Xu, Chen Meng, Xiaohua Yang, Wei Yan, and Wentao Fang. Deciphering tissue‐based proteome signatures revealed novel subtyping and prognostic markers for thymic epithelial tumors. Molecular Oncology 14 (2020) 721–741. (*Co-first author)
12. Xin Ku*, Yan Xu, Chunlin Cai, Yi-Li Yang, Long Cui, and Wei Yan. In-depth Characterization of Mass Spectrometry-based Proteomic Profiles revealed Novel Signature Proteins Associated with Liver Metastatic Colorectal Cancers. Analytical Cellular Pathology. 2019. doi.org/10.1155/2019/7653230. (* corresponding author)
11. Xin Ku and Wei Yan. Discovering Protein Biomarkers from Clinical Peripheral Blood Mononuclear Cells Using Data-Independent Acquisition Mass Spectrometry. Methods Mol Biol. 2019;1959:151-161. doi: 10.1007/978-1-4939-9164-8_10.
10. Qiangling Sun*, Xin Ku*, Ning Xu, Xuefei Zhang, Wei Yan, Wentao Fang. Investigation of an optimal lysis method for the study of thymus and thymoma by mass spectrometry-based proteomics. Transl. Cancer Res. 2018;7(2):391-400. doi: 10.21037/tcr.2018.03.35 (Co-first author)
9. Yan Xu, Xin Ku, Chunrong Wu, Chunlin Cai, Jianguo Tang and Wei Yan. Exosomal proteome analysis of human plasma to monitor sepsis progression. Biochemical and Biophysical Research Communications. 499 (2018) 856e861. doi: 10.1016/j.bbrc.2018.04.006.
8. Yiqing Tong, Xin Ku, Chunrong Wu, Jianjun Liu, Chunhui Yang, Wenzhi Tang, Wei Yan, Jianguo Tang. Data‐independent acquisition‐based quantitative proteomic analysis reveals differences in host immune response of peripheral blood mononuclear cells to sepsis. Scand J Immunol. 2019;89:e12748. doi: 10.1111/sji.12748
7. Xin Ku, Sabine Schweizer, Iris Antes and Bernhard Kuster. Expanding kinome coverage: Discovery and characterization of a new probe for VEGFR drug selectivity profiling using quantitative chemical proteomics. Journal of Proteome Research. 2014, 13 (5), pp 2445–2452.
6. Xin Ku, Stephanie Heinzlmeir, Xiaofeng Liu, Guillaume Médard and Bernhard Kuster. A new chemical probe for quantitative proteomic profiling of fibroblast growth factor receptor and its inhibitors. Journal of Proteomics. 2014 Jan; 96:44-55.
5. Xin Ku, He Huang, Hualiang Jiang and Hong Liu. Efficient Iron/Copper Cocatalyzed S–Arylations of Thiols with Aryl Halides. ACS Combinatorial Sciences, 2009, 11, 338–340. (Highlighted by ChemInform Abstract, Wiley. Volume 40, Issue 39, September 29, 2009)
4. Guillaume Médard, Fiona Pachl, Benjamin Ruprecht, Susan Kläger, Stephanie Heinzlmeir, Dominic Helm, Huichao Qiao, Xin Ku, Mathias, Wilhelm, Thomas Kuehne, Zhixiang Wu， Antje Dittmann, Carsten Hopf, Karl Kramer and Bernhard Kuster. Optimized chemical proteomics assay for kinase inhibitor profiling. Journal of Proteome Research. 2015, 14 (3), pp 1574–1586.
3. Wei Zhou, Xiaofeng Liu, Zhengchao Tu, Lianwen Zhang, Xin Ku, Fang Bai, Zhenjiang Zhao, Yufang Xu,, Ke Ding, Honglin Li. Discovery of pteridin-7(8H)-one-based Irreversible Inhibitors targeting Epidermal Growth Factor Receptor (EGFR) Kinase T790M/L858R mutant. Journal of Medicinal Chemistry. 2013, 56, 7821−7837.
2. Jiayu Gong, Chaoqian Cai, Xiaofeng Liu, Xin Ku, Hualiang Jiang, Daqi Gao and Honglin Li. ChemMapper: a versatile web server for exploring pharmacology and chemical structure association based on molecular 3D similarity method. Bioinformatics, 2013. 29(14) : 1827-1829
1. He Huang, Qin Chen, Xin Ku, Linghua Meng, Liping Lin, Caihua Zhu, Zhi Chen, Ming Li, Hualiang Jiang, Kaixian Chen, Jian Ding and Hong Liu. A class of Novel alpha-Heterocyclic Carboxaldehyde Thiosemicarbazones Inhibit Topoisomerase II-alpha catalytic activity. Journal of Medicinal Chemistry. Journal of Medicinal Chemistry, 2010, 53 (8), 3048–3064
主持
1. 上海交通大学医工交叉 面上项目 “靶向蛋白组学筛选胸腺瘤恶性转化及病理分型相关标记物”在研，合作主持，21万元 2017-2019
2. 国家自然科学基金青年项目，在研，主持，25万，2018-2020
3. 上海市青年科技英才“扬帆计划”已结题，主持，20万元，2016-2019
4. 上海交大青年教师启动基金，已结题，主持，10万元，2015-2018
参与
1. 2016年国家重点研发计划“基于组学特征谱的未知原发灶骨转移癌的分子分型研究” 2016YFC0902101，课题骨干
2. 2016年国家重点研发计划“病原菌核糖体新调节因子的发现、鉴定及调控机制研究” 2016YFA0500600，课题骨干
3. 上海交通大学医工交叉 重点项目A类，基于DIA定量蛋白质组学技术进行胸腺肿瘤的精准分型 2019-2021，课题骨干
