学习经历
2003/09 – 2008/10，上海交通大学，生命科学技术学院，博士
1999/09 – 2003/06，华东师范大学，生命学院，学士

 

工作经历
2019/08－2020/08，Rutgers The State University of New Jersey (美国新泽西州立罗格斯大学)，Department of Biochemistry and Microbiology（生化与微生物系），访问学者
2015/01－今， 上海交通大学，系统生物医学研究院，副研究员
2011/01－2014/12，上海交通大学，系统生物医学研究院，助理研究员
2008/12－2010/12，中国科学院，上海生命科学研究院，博士后
2006/03—2007/12，雀巢研发中心（瑞士），生物分析部，博士研究生

 

人才奖项
2014/07-2017/06，上海交通大学科技创新专项资金SMC-晨星青年学者奖励计划

 

学会兼职与审稿人
审稿人
The ISME Journal (IF 9.267)
Microbiome (IF 9.133)
Scientific Reports (IF 4.122)
Critical Reviews in Food Science and Nutrition (IF 6.202)

1. 肠道菌群与新生儿和儿童疾病的关系
2. 母婴之间的共生菌垂直传递

第一/通讯作者
(1) Chen, Q., G. Wu, H. Chen, H. Li, S. Li, C. Zhang, X. Pang, L. Wang, L. Zhao and Shen, J. *（通讯作者） Quantification of Human Oral and Fecal Streptococcus parasanguinis by Use of Quantitative Real-Time PCR Targeting the groEL Gene. Frontiers in microbiology 2019, 10: 2910. doi:10.3389/fmicb.2019.02910 (IF 4.076)
(2) Wang, X., Lu, H., Feng, Z., Cao, J., Fang, C., Xu, X., Zhao, L., and Shen, J. *（通讯作者）Development of Human Breast Milk Microbiota-Associated Mice as a Method to Identify Breast Milk Bacteria Capable of Colonizing Gut. Frontiers in microbiology 2017, 8:1242; doi: 10.3389/fmicb.2017.01242 (IF 4.076)
(3) Wang, J., Tang, H., Wang, X., Zhang, X., Zhang, C., Zhang, M., Zhao, Y., Zhao, L., Shen, J. *（通讯作者）: The structural alteration of gut microbiota in low-birth-weight mice undergoing accelerated postnatal growth. Sci. Rep. 2016, 6: 27780; doi: 10.1038/srep27780 （IF 5.578）
(4) Zhang, C.#, Yin, A.#, Li, H.#, Wang, R.#, Wu, G.#, Shen, J.#（共同第一作者）, Zhang, M., Wang, L., Hou, Y., Ouyang, H., Zhang, Y., Zheng, Y., Wang, J., Lv, X., Wang, Y., Zhang, F., Zeng, B., Li, W., Yan, F., Zhao, Y., Pang, X., Zhang, X., Fu, H., Chen, F., Zhao, N., Hamaker, B.R., Bridgewater, L.C., Weinkove, D., Clement, K., Dore, J., Holmes, E., Xiao, H., Zhao, G., Yang, S., Bork, P., Nicholson, J.K., Wei, H., Tang, H.*, Zhang, X.* and Zhao, L.*: Dietary modulation of gut microbiota contributes to alleviation of both genetic and simple obesity in children. Ebiomedicine. 2015, 2: 968-984 (IF 6.183)
(5) Wang, J., H. Tang, C. Zhang, Y. Zhao, M. Derrien, E. Rocher, J. van-Hylckama Vlieg, K. Strissel, L. Zhao, M. Obin, J. Shen*（通讯作者）: Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice. ISME J 2015, 9:1-15 （IF 9.267）
(6) Feng, J., H. Tang, M. Li, X. Pang, L. Wang, M. Zhang, Y. Zhao, X. Zhang, J. Shen*（通讯作者）: The abundance of fecal Faecalibacterium prausnitzii in relation to obesity and gender in Chinese adults. Archives of Microbiology 2014, 196(1):73-77 (IF 1.8)
(7) Shen, J., M. S. Obin, L. Zhao*: The gut microbiota, obesity and insulin resistance. Molecular Aspects of Medicine 2013, 34(1):39-58 (IF 10.860)
(8) Shen, J., B. Zhang, H. Wei, C. Che, D. Ding, X. Hua, P. Bucheli, L. Wang, Y. Li, X. Pang, L. Zhao*: Assessment of the modulating effects of fructo-oligosaccharides on fecal microbiota using human flora associated piglets. Archives of Microbiology 2010, 2:959–968 (IF 1.8)
(9) Shen, J., B. Zhang, G. Wei, X. Pang, H. Wei, M. Li, Y. Zhang, W. Jia, and L. Zhao*: Molecular Profiling of the Clostridium leptum Subgroup in Human Fecal Microflora by PCR-Denaturing Gradient Gel Electrophoresis and Clone Library Analysis. Applied and Environmental Microbiology 2006, 72(8):5232-5238 (IF 3.633)
(10) 李娜，赵宇峰，申剑*（通讯作者）：人母乳葡萄球菌和链球菌菌株的抗氧化作用. 基因组学与应用生物学（ISSN：1674-568X）2020，已接受
(11) 陈秋蓉，王凌华，赵立平，申剑*（通讯作者）：细菌汞抗性基因merA特异性的三对PCR引物的检测范围的比较. 基因组学与应用生物学（ISSN：1674-568X）2019，已接受
(12) 曹杰，申剑*（通讯作者）：人母乳细菌 Streptococcus Salivarius F286 和 S. Parasanguinis F278 对 HT29 细胞的细胞毒性. 基因组学与应用生物学（ISSN：1674-568X） 2019，38(7):3030-3036
(13) 王晓鑫，申剑*（通讯作者）：线虫偏好性行为试验中两种设立方法的比较. 基因组学与应用生物学（ISSN：1674-568X） 2018, 37(6):2403-2808
(14) 唐璜，王京晶，吴欢，赵宇峰，张旭，申剑*（通讯作者）: 哺乳期过度喂养对幼鼠肥胖和肠道菌群结构的影响. 中国微生态学杂志 2013，25(8):874-881
(15) 冯洁，华蔚颖，赵立平，赵宇峰，申剑*（通讯作者）: 检测肠道细菌Feacalibacterium prausnitzii的三对PCR引物的特异性比较. 微生物学报 2011, 56(1):112-121
(16) 申剑，张宝让，魏华，庞小燕，赵立平: 三种粪便总DNA提取方法的比较. 中国微生态学杂志 2008, 20(1): 28-30
(17) 申剑，《微生物组学与精准医学》编委，赵立平主编. 2017. 上海交通大学出版社
(18) 申剑，赵立平. 第32章：以肠道菌群为靶点防治代谢综合征的研究：膳食、肠道菌群与代谢综合征. 《前沿生命的启迪》，乔中东、贺林主编. 2016. 科学出版社
其他作者
(1) Wang J, Lang T, Shen J, Dai J, Tian L and Wang X. Core Gut Bacteria Analysis of Healthy Mice. Frontiers in microbiology 2019, 10:887. doi: 10.3389/fmicb.2019.00887
(2) Tong X#*, Xu J#, Lian F#, Yu X, Zhao Y, Xu L, Zhang M, Zhao X, Shen J, Wu S, Pang X, Tian J, Zhang C, Zhou Q, Wang L, Pang B, Chen F, Peng Z, Wang J, Zhen Z, Fang C, Li M, Chen L, Zhao L*: Structural Alteration of Gut Microbiota during the Amelioration of Human Type 2 Diabetes with Hyperlipidemia by Metformin and a Traditional Chinese Herbal Formula: a Multicenter, Randomized, Open Label Clinical Trial. mBio, 2018, 9 (3). doi:10.1128/mBio.02392-17 (IF 6.956)
(3) Wang, R., Li, H., Yang, X., Xue, X., Deng, L., Shen, J., Zhang, M., Zhao, L., Zhang, C.* : Genetically Obese Human Gut Microbiota Induces Liver Steatosis in Germ-Free Mice Fed on Normal Diet. Frontiers in microbiology 2018, 9:1602; doi:10.3389/fmicb.2018.01602 (IF 4.019)
(4) Wu, G., Zhang, C., Wu, H., Wang, R., Shen, J., Wang, L., Zhao, Y., Pang, X., Zhang, X., Zhao, L., and Zhang, M.: Genomic Microdiversity of Bifidobacterium pseudocatenulatum Underlying Differential Strain-Level Responses to Dietary Carbohydrate Intervention. mBio, 2017, 8(1) doi: 10.1128/mBio.02348-16（IF 6.956）
(5) Liu, R., Zhang, C., Shi, Y., Zhang, F., Li, L., Wang, X., Ling, Y., Fu, H., Dong, W., Shen, J., Reeves, A., Greenberg, A. S., Zhao, L., Peng, Y., and Ding, X. (2017) Dysbiosis of Gut Microbiota Associated with Clinical Parameters in Polycystic Ovary Syndrome. Frontiers in microbiology 8: 324 (IF 4.076)
(6) Wu, G., Zhang, C., Wang, J., Zhang, F., Wang, R., Shen, J., Wang, L., Pang, X., Zhang, X., Zhao, L. and Zhang, M.: Diminution of the gut resistome after a gut microbiota-targeted dietary intervention in obese children. Sci. Rep. 2016; 6: 24030. （IF 5.578）
(7) Karl, J. P., Fu, X., Wang, X., Zhao, Y., Shen, J., Zhang, C., Wolfe, B. E., Saltzman, E., Zhao, L. * and Booth* S. L. *: Fecal menaquinone profiles of overweight adults are associated with gut microbiota composition during a gut microbiota-targeted dietary intervention. Am J Clin Nutr 2015, 102(1): 84-93
(8) Wei, H., J. Shen, X. Pang, D. Ding, Y. Zhang, B. Zhang, H. Lu, T. Wang, C. Zhang, X. Hua, L. Cui, L. Zhao: Fatal infection in human flora-associated piglets caused by the opportunistic pathogen Klebsiella pneumoniae from an apparently healthy human donor. Journal of veterinary medical science 2008, 70(7):715-717
(9) Zhao, L., J. Shen: Whole-body systems approaches for gut microbiota-targeted, preventive healthcare. Journal of Biotechnology 2010, 149:183-190
(10) Xiao, S., N. Fei, X. Pang, J. Shen, L. Wang, B. Zhang, M. Zhang, X. Zhang, C. Zhang, M. Li, L. Sun, Z. Xue, J. Wang, J. Feng, F. Yan, N. Zhao, J. Liu, W. Long, L. Zhao: A gut microbiota-targeted dietary intervention for amelioration of chronic inflammation underlying metabolic syndrome. FEMS Microbiology Ecology 2014 87(2):357-367
(11) Li, M., B. Wang, M. Zhang, M. Rantalainen, S. Wang, H. Zhou, Y. Zhang, J. Shen, X. Pang, M. Zhang, H. Wei, Y. Chen, H. Lu, J. Zuo, M. Su, Y. Qiu, W. Jia, C. Xiao, L. M. Smith, S. Yang, E. Holmes, H. Tang, G. Zhao, J. K. Nicholson, L. Li, and L. Zhao: Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci U S A 2008, 105:2117-22.
(12) Zhao, L., Nicholson, J.K., Lu, A., Wang, Z., Tang, H., Holmes, E., Shen, J., Zhang, X., Li, J.V., Lindon, J.C. Targeting the Human Genome-Microbiome Axis for Drug Discovery: Inspirations from Global Systems Biology and Traditional Chinese Medicine. J Proteome Res 2012,11(7):3509-3519
(13) Che, C., X. Pang, X. Hua, B. Zhang, J. Shen, J. Zhu, H. Wei, L. Sun, P. Chen, L. Cui, L. Zhao, and Q. Yang: Effects of human fecal flora on intestinal morphology and mucosal immunity in human flora-associated piglet. Scandinavian Journal of Immunology 2008, 69:223-233.4
(14) Zhao, L., J. Shen. Chapter 4: Functional Metagenomics and Systems Biology: understanding the human organismal complexity in disease and health. In Book Metagenomics: Current Innovations and Future Trends, D. Marco, ed. 2011. Caister Academic Press
(15) 方超，徐佳，李娜，张晓君，申剑，赵宇峰*: 人肠道内Faecalibacterium prausnitzii的分离、鉴定及优良菌株筛选研究. 基因组学与应用生物学（ISSN：1674-568X） 2018, 37(7):2866-2873
(16) 张宝让，王转花，庞小燕，魏华，申剑，赵立平: 健康个体粪便样本分离到的溶血菌的分离与鉴定. 中国微生态学杂志 2005, 17(6):422-424
(17) 袁军，李旻，申剑，赵立平，庞小燕: 两种粪便保存方法对肠道菌群结构研究的影响. 中国微生态学杂志 2009, 21(03):223-225

(1) 2016/01-2019/12，国家自然基金面上基金项目：肠道菌群失调在追赶生长导致的代谢综合征中的病因学作用研究。项目批准号81570809，项目主持人。
(2) 2012/01-2014/12, 国家自然基金青年科学基金项目：追赶生长、肠道菌群结构变化与罹患代谢综合征风险的关系研究。项目批准号81100632，项目主持人。
(3) 2017/01 – 2019/12，上海交通大学医工交叉研究基金面上项目：肠道菌群结构变化与儿童原发性肾病综合征激素依赖现象的相关性研究。项目负责人之一
(4) 2016/02 – 2018/01，美国NIH R21项目：Methylmercury Exposure Through Rice Ingestion, Gut Microbes, and Offspring Development。项目批准号Grant Number: 1R21ES026412-01 FAIN: R21ES026412，项目负责人之一
(5) 2016/01-2018/12，上海交通大学医工交叉研究基金面上项目：肠道菌群重建通过脑-肠-脂肪轴对多囊卵巢综合征患者糖脂代谢和生殖功能的影响。项目负责人之一。

独立指导硕士研究生8名，其中已毕业4名。
独立指导博士研究生1名，其中已毕业1名。