师资概况
姓名 吴强
职称 教授、研究员
电话
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邮箱qiangwuATsjtu.edu.cn
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学习工作经历:

                  1998获美国纽约州立大学石溪分校和冷泉港实验室细胞发育生物学博士

                  1999年获得哈佛大学Damon Runyon Fellowship

                  上海交通大学特聘教授,系统生物医学教育部重点实验室常务副主任

                  上海交通大学比较生物医学中心主任,科技部重大科学研究计划项目首席科学家

                  中美生命科学家学会终身会员

人才奖项:       
                  上海市浦江学者



研究方向:

           用比较生物医学手段,通过实验动物建模,研究原钙黏蛋白在脑发育和脑功能中的细胞分子机制及UGT家族在药物代谢中的结构功能和表达调控机制,以小鼠为模式动物研究人类重要常见复杂神经疾病的发生发展机理,为最终对其有效治疗提供理论基础。

发表论文:

  1. Huang H, Wu Q. CRISPR Double Cutting through the Labyrinthine Architecture of 3D Genomes. Journal of Genetics and Genomics. 2016;43(5):273-88.
  2. 2.Yanan Z, Quan X, Ya G, Qiang W. Characterization of a cluster of CTCF-binding sites in a protocadherin regulatory region. Yi chuan = Hereditas. 2016;38(4):323-36.
  3. Yanan Z, Quan X, Ya G, Qiang W. Characterization of a cluster of CTCF-binding sites in a protocadherin regulatory region. Yi chuan = Hereditas. 2016;38(4):323-36.
  4. Guo Y., Monahan K., Wu H., Varley KE., Gertz J., Li W., Myers RM., Maniatis T., Wu Q. (2012) CTCF/Cohesin-mediated DNA Looping is required for protocadherin alpha promoter choice. Proc Natl Acad Sci USA 109: 21081-21086.
  5. Suo L., Lu H., Ying G., Capecchi M.R., Wu, Q. (2012) Protocadherin clusters and cell adhesion kinase regulate dendrite complexity through Rho GTPase. J Mol Cell Biol 4: 362-376. Cover Article
  6. Huang, HY; WU, Q. (2010). Cloning and comparative analyses of the zebrafish Ugt repertoire reveal Its evolutionary diversity. PLoS One 5: e9144.
  7. Ying, G., Wu, S., Hou, R., Huang, W., Capecchi, M., Wu, Q. (2009). Protocadherin Celsr3 is required for interneuron migration in the mouse forebrain. Molecular and Cellular Biology 29: 3045-3061.
  8. Wu, S., Ying, G., Wu, Q., and Capecchi, M.R. (2007). Towards simpler and faster genome-wide mutagenesis in mice. Nature Genetics 39: 922-930.
  9.  Zou, C., Huang, W., Ying, G., and Wu, Q. (2007). Sequence analysis and expression mapping of the rat clustered protocadherin gene repertoires. Neuroscience 144:579-603.
  10. Wu, Q. (2005). Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes. Genetics 169:2179-2188.
  11. Zhang, T., Haws, P., and Wu, Q. (2004) Multiple variable first exons: a mechanism for cell- and tissue- specific gene regulation. Genome Research 14: 70-89.
  12. Wu, Q. and Maniatis, T. (1999) A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell 97: 779-790.
  13. Wu, Q. and Krainer, A.R. (1996) U1-mediated exon definition interactions between AT-AC and GT-AG introns. Science 274: 1005-1008.

      


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