Name CHEN, Zhu
Professional Title Professor
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​M.D., Ph.D.  in Oncology, University of Paris Diderot, Paris 7, Insitute of hematology
Professor, Member of Chinese Academy of Sciences
Vice chairman of the Standing Committee of the twelfth CPPCC National Committee, chairman of the Chinese Peasants and Workers Democratic Party

    According to the concept of integrative biology- a strategy for systems biomedicine, we have aimed to clarify the molecular regulatory networks related to targeting therapy for leukemia, to apply new approaches for disease prevention, diagnosis and treatment, to explore the fundamental targeting intervention strategies for leukemia therapy fundamentally.
1)    Wang L, Zhou GB, Liu P, Song JH, Liang Y, Yang XJ, Xu F, Wang BS, Mao JH, Shen ZY, Chen SJ, Chen Z. Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia. Proc Natl Acid Sci USA 2008; 105: 4826-4831. IF:9.598

2)    Zhang SJ, Ma LY, Huang QH, Li G, Gu BW, Gao XD, Shi JX, Wang YY, Gao L, Cai X, Ren RB, Zhu J, Chen Z, Chen SJ. Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemia. Proc Natl Acid Sci USA 2008;105:2076-2081. IF:9.598
3)    Sun XJ, Xu PF, Zhou T, Hu M, Fu CT, Zhang Y, Jin Y, Chen Y, Chen SJ, Huang QH, Liu TX, Chen Z. Genome-wide survey and development expression mapping of zebrafish SET domain-containing genes. PLoS ONE 2008; 3: e1499. IF:3.534
4)    Wang ZY, Chen Z. Acute promyelocytic leukemia: from highly fatal to highly curable. Blood 2008; 111:2505-2515. IF:9.775
5)    Zhang NN, Shen SH, Jiang LJ, Zhang W, Zhang HX, Sun YP, Li XY, Huang QH, Ge BX, Chen SJ, Wang ZG, Chen Z, Zhu J. RIG-I plays a critical role in negatively regulating granulocytic proliferation. Proc Natl Acid Sci USA 2008; 105: 10553-10558. IF:9.598
6)    Le HY, Zhang Y, Liu H, Ma LH, Jin Y, Huang QH, Deng M, Chen Y, Chen Z, Chen SJ, Liu TX. EENA promotes myeloid proliferation through stimulating ERK1/2 phosphorylation in zebrafish. JBC 2008; 283:17652-17661. IF:4.6

7)    Zhang Y, Bai XT, Zhu KY, Jin Y, Deng M, Le HY, Fu YF, Chen Y, Zhu J, Chen Z, John Kanki, A. Thomas Look, Chen SJ, Liu TX. In vivo interstitial migration of primitive macrophages mediated by JNK-Mmp13 signaling in response to acute inflammation. The Journal of Immunology 2008; 181:2155-2164. IF:5.362

1)Hu J, Liu YF, Wu CF, Xu F, Shen ZX, Zhu YM, Li JM, Tang W, Zhao WL, Wu W, Sun HP, Chen QS, Chen B, Zhou GB, Zelent A, Waxman S, Wang ZY, Chen SJ, Chen Z. Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide based therapy in newly diagnosed acute promyelocytic leukemia. Proc Natl Acad Sci USA 2009;106:3342-3347. IF:9.598
2)Zhang QY, Mao JH, Liu P, Huang QH, Lu J, Xie YY, Weng L, Zhang Y, Chen Q, Chen SJ, Chen Z. A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL associated leukemia. Proc Natl Acad Sci USA 2009;106: 3378-3383. IF:9.598
3)Song HD, Liang J, Shi JY, Zhao SX, Liu Z, Zhao JJ, Peng YD, Gao GQ, Tao J, Pan CM, Shao L, Cheng F, Wang Y, Yuan GY, Xu C, Han B, Huang W, Chu X, Chen Y, Sheng Y, Li RY, Su Q, Gao L, Jia WP, Jin L, Chen MD, Chen SJ, Chen Z, Chen JL. Functional SNPs in the SCGB3A2 promoter are associated with susceptibility to Graves' disease. Hum Mol Genet. 2009; 18:1156-1170.IF:6.677
Hu M, Sun XJ, Zhang YL, Kuang Y, Wu CQ, Wu WL, Shen SH, Du TT, Li H, He F, Xiao HS, Wang ZG, Liu TX, Lu H, Huang QH, Chen SJ, Chen Z. Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling. Proc Natl Acad Sci USA 2010; 107:2956-2961. IF:9.598
1) Yan XJ, Xu J, Gu ZH, Pan CM, Lu G, Shen Y, Shi JY, Zhu YM, Tang L, Zhang XW, Liang WX, Mi JQ, Song HD, Li KQ, Chen Z, Chen SJ. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nature Genetics 2011; 43:309-315. IF:29.648
2)  Chen SJ, Zhou GB, Zhang XW, Mao JH, de Thé H, Chen Z. From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia. Blood 2011;117:6425-6437. IF:9.775
1) Liu JX, Zhou GB, Chen SJ, Chen Z. Arsenic compounds: revived ancient remedies in the fight against human malignancies.Curr Opin Chem Biol. 2012; 16:92-98. IF:7.652
2)  Zhen T, Wu CF, Liu P, Wu HY, Zhou GB, Lu Y, Liu JX, Liang Y, Li KQ, Wang YY, Xie YY, He MM, Cao HM, Zhang WN, Chen LM, Petrie K, Chen SJ, Chen Z. Targeting of AML1-ETO in t(8;21) leukemia by oridonin generates a tumor suppressor-like protein. Science Translational Medicine 2012; 4:127ra38. IF:14.414
1)Wang JH, Chen WL, Li JM, Wu SF, Chen TL, Zhu YM, Zhang WN, Li Y, Qiu YP, Zhao AH, Mi JQ, Jin J, Wang YG, Ma QL, Huang H, Wu DP, Wang QR, Li Y, Yan XJ, Yan JS, Li JY, Wang S, Huang XJ, Wang BS, Jia W, Shen Y, Chen Z, Chen SJ. Prognostic significance of 2-hydroxyglutarate levelsin acute myeloid leukemia in China.Proc Natl Acad Sci USA2013; 110:17017-17022. IF:9.598
2)Shen Y, Wang JH, Chen WL, Jia W, Chen SJ, Chen Z. Reply to Struys: Role of biomarker of 2-hydroxyglutarate in acute myeloid leukemia.PNAS 2013;110:4940. IF:9.809
3)  Zheng HJ, Zhang WB, Zhang L, Zhang ZZ, Li J, Lu G, Zhu YQ, Wang YZ, Huang Y, Liu J, Kang H, Chen J, Wang LJ, Chen AJ, Yu ST, Gao ZC, Jin L, Gu WY, Wang ZQ, Zhao L, Shi BX, Wen H, Lin RY, Malcolm K Jones, Brona Brejova, Tomas Vinar, Zhao GP, Donald P McManus, Chen Z, Zhou Y, Wang SY. The genome of the hydatid tapeworm Echinococcus granulosus. Nature Genetics 2013; 45:1168-1177.IF:29.648

4) Xiao R, Xi XD, Chen Z, Chen SJ, Meng G. Structural framework of c-Src activation by integrin β3. Blood 2013;121:700-6 IF:9.775

1.    Cai L, Deng SL, Liang L, Pan H, Zhou J, Wang MY, Yue J, Wan CL, He G, He L. Identification of genetic associations of SP110/MYBBP1A/RELA with pulmonary tuberculosis in the Chinese Han population. Hum Genet. 2013 Mar;132(3):265-73
2.    Cao X, Liang Y, Zhao L, Le H. Mobility of Pb, Cu, and Zn in the phosphorus-amended contaminated soils under simulated landfill and rainfall conditions. Environ Sci Pollut Res Int. 2013 Sep;20(9):5913-21

3.    Chen Y, Yang LN, Cheng L, Tu S, Guo SJ, Le HY, Xiong Q, Mo R, Li CY, Jeong JS, Jiang L, Blackshaw S, Bi LJ, Zhu H, Tao SC, Ge F. Bcl2-associated Athanogene 3 Interactome Analysis Reveals a New Role in Modulating Proteasome Activity. Mol Cell Proteomics. 2013 Oct;12(10):2804-19.

4.    Wu, S. and H. Le. Dual roles of PKM2 in cancer metabolism. Acta Biochimica Et Biophysica Sinica 2013 Jan;45(1):27-35.
5.    Yang J, Chen T, Sun L, Zhao Z, Qi X, Zhou K, Cao Y, Wang X, Qiu Y, Su M, Zhao A, Wang P, Yang P, Wu J, Feng G, He L, Jia W, Wan C. Potential metabolite markers of schizophrenia. Mol Psychiatry. 2013 Jan; 18(1): 67–78. 

​      Our clinical research group has made a major breakthrough in treatment of acute promyelocytic leukemia. Clinical data showed that 5-year event-free survival for the whole group was over 90%. What’s more, we first elucidated rationales and molecular mechanisms of the compatibility of “Jun”, “Chen”, “Zuo” and “Shi” in the treatment of APL with Realgar-Indigo naturalis formula, contributing to helping to the elucidation of clarify the mechanisms of multi-target therapy of Traditional Chinese Medicine (TCM). We also found Oridonin exert the most sensitive effect in AML-M2b cells. The oridonin-based combination therapy is expected to become an optimizedation scheme for AML-M2b.
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