研究组采用转化医学的方式，运用生物化学、分子生物学、细胞生物学、高通量检测、生物信息学、计算机辅助药物设计、酶动力学、疾病细胞模型、化学生物学、分子药理学等方法对酶小分子抑制剂/激活剂发现、酶底物发现和疾病机理研究、酶功能进行研究。目前已对神经退行性疾病、耐药菌、免疫、肿瘤相关疾病等的靶点蛋白酶，发现了多种结构全新的高效抑制剂和新型酶底物，并对其作用机理进行了进一步的阐述，相关研究结果发表在FASEB J.、Chem. Comm.、J. Med.Chem.、ACS Chem. Biol. (Cover Story)、Cell Death and Disease, Mol. Cancer Ther..、J. Bio. Chem.和ChemBioChem等杂志上，并申请专利多项。我们热忱欢迎杰出的研究人员加入我们的团队，或者开展科研合作，并希望得到更多临床病人的帮助。
代表性成果
1. Youtian Hu#, Lu Wang#, Xu Han#, Yueyang Zhou, Tonghui Zhang, Li Wang, Ting Hong, Wei Zhang, Xun-Xiang Guo, Jielin Sun, Yingxin Qi, Jing Yu*, Hong Liu*, Fang Wu*. Discovery of a Bioactive Inhibitor with a New Scaffold for Cystathionine γ-Lyase.
Journal of Medicinal Chemistry, 2018 62(3), 1677–1683 Cover Story
2. Li Wang#, Hao Cai#, Youtian Hu, Fan Liu, Shengshuo Huang, Yueyang Zhou, Jing Yu*, Jinyi Xu* and Fang Wu*. A pharmacological probe identifies cystathionine β-synthase as a new negative regulator for ferroptosis.
Cell Death & Disease, 2018 9: 1005
3. Yinzhong Lu, Jun Wan#, Zhifeng Yang#, Xiling Lei, Qi Niu, Lanxin Jiang, Willemijn M. Passtoors, Aiping Zang, Patrick C. Fraering, and Fang Wu*. Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells.
The FASEB Journal, Apr;31(4):1382-1397. doi: 10.1096/fj.201600702R. Epub 2016 Dec 29.
4. Jie Ren#, Yuanyuan Zhang#, Huizi Jin, Jing Yu, Yueyang Zhou, Fang Wu* and Weidong Zhang*. Novel Inhibitors of Human DOPA Decarboxylase Extracted from Euonymus glabra Roxb.
ACS Chem. Biol. 2014 9(4) 897-903. Cover Story
5. Yueyang Zhou#, Jing Yu#, Xiling Lei, Jianying Wu, Qi Niu, Yixuan Zhang, Hong Liu, Philipp Christen, Heinz Gehring and Fang Wu*. High-throughput tandem-microwell assay identifies inhibitors of hydrogen sulfide signaling pathway.
Chem Commun. 2013, 49, 11782-84.
