师资队伍

何昆燕

 

电话: 34206124
传真:
邮箱: khe@sjtu.edu.cn
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学习经历
2003/09-2006/06, 复旦大学,神经生物学系,博士
2000/09-2003/06,华中农业大学,作物遗传育种,硕士
1996/09-2000/06,华中农业大学,作物遗传育种,学士

 

工作经历
1. 2016/1-至今,上海交通大学,系统生物医学研究院,副研究员
2. 2013/2-2015/12,上海交通大学,系统生物医学研究院,助理研究员
3. 2008/06-2012/08,美国埃默里大学,病理系,博士后,合作导师:Keqiang Ye
4. 2007/01-2008/05, 美国匹兹堡大学,神经病学系,博士后,合作导师:Michael J. Zigmond

 

人才奖项
上海交通大学“晨星青年学者奖励计划”
上海市浦江人才

 

肿瘤治疗新靶点新疗法

1. Zhang QW ; Bu SX ; Sun JY; Xu MH; Yao XF; He KY; Lai DM*. Paracrine effects of human amniotic epithelial cells protect against chemotherapy-induced ovarian damage, Stem Cell Res Ther, 2017.11.28, 8(1): 270~283
2. Yu HL, Jiang SH, Bu XL, Wang JH, Weng JY, Yang XM, He KY, Zhang ZG, Ao P, Xu J, Xu MJ. Structural diversity of anti-pancreatic cancer capsimycins identified in mangrove-derived Streptomyces xiamenensis 318 and post-modification via a novel cytochrome P450 monooxygenase. Sci Rep. 2017 Jan 18;7:40689. doi: 10.1038/srep40689
3. Shi Y, Su XB, He KY, Wu BH, Zhang BY, Han ZG. Chromatin accessibility contributes to simultaneous mutations of cancer genes. Sci Rep. 2016 Oct 20;6:35270. doi: 10.1038/srep35270.
4. Wang X., Zhang Y., Han Z., He K#. Malignancy of Cancers and Synthetic Lethal Interactions Associated With Mutations of Cancer Driver Genes. Medicine (Baltimore). 2016 Feb;95(8):e2697. doi: 10.1097/MD.0000000000002697. (#Corresponding author)
5. Han B., He K., Cai C., Tang Y., Yang L., Heinemann SH., Hoshi T., Hou S. Human EAG channels are directly modulated by PIP2 as revealed by electrophysiological and optical interference investigations. Science Report. 2016 Mar 23;6:23417. doi: 10.1038/srep23417.
6. He, K., Qi, Q., Chan,C., Xiao,G., Liu, X., Tucker-Burden, C., Wang, L., Mao, H., Lu, X., McDonald, F., Luo, H., Fan, W., Weiss, W., Sun, S., Brat, D., and Ye, K. Blockade of Glioma Proliferation Through Allosteric Inhibition of JAK2. Science Signaling, 2013. Jul 9; 6(283):ra55.
7. Qi Q, He K, Liu X, Pham C, Meyerkord C, Fu H, and Ye, K.. Disrupting the PIKE-A/Akt interaction inhibits glioblastoma cell survival, migration, invasion, and colony formation. Oncogene, 2013. Feb 21; 32(8): 1030-40.
8. Qi, Q., He, K., Yoo, M.H., Chan, C.B., Liu, X., Zhang, Z., Olson, J.J., Xiao, G., Wang, L., Mao, H., Fu, H., Sun, S.Y., Michel, P.S. and Ye, K. Acridine yellow G blocks glioblastoma growth via dual inhibition of epidermal growth factor receptor and protein kinase C Kinases. J Biol Chem, 2012, 287(9):6113-27 (Co-first author)
9. He, K., Jang, S.W., Joshi, J., Yoo, M.H. and Ye, K. Akt-phosphorylated PIKE-A Inhibits UNC5B-induced Apoptosis in Cancer Cell Lines in a P53-dependent Manner. Mol Biol Cell, 2011, 22(11):1943-1954.
10. He, K., Liu, X., Chan, C.B., Jia, Y., Luo, Y.R., France, S.A., Ye, K. Identification of a Small Molecular Activator for Insulin Receptor with Potent Anti-diabetic Effects in Mice. J Biol Chem, 2011 Oct 28; 286(43): 37379-88.
11. Chan, C.B., Liu, X., He, K., Qi, Q., Jung, D., Kim, J. and Ye, K.. The association of phosphoinositide 3-kinase enhancer A with hepatic insulin receptor enhances its kinase activity. EMBO Rep, 2011, 12(8): 847-854.
12. Liu, X., Chan, C.B., Jang, S.W., Pradoldej, S., Huang, J., He, K., Phun, L.H., France, S., Xiao, G., Jia, Y., Luo, H.R. and Ye, K. A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect. J Med Chem, 2010, 53(23): 8274-8286.
13. He, K., Yang, S., Shen, D., Zhang, L., Lu, S. and Sun, F. Excision repair cross complementing 1 express protects brain against ischemic injury following middle cerebral artery occlusion in rat brain. Gene Ther, 2009, 16(7): 840–848.

1. 国家自然科学基金中德国际合作项目,81761138045,血红素和血红素降解产物调节神经兴奋性的细胞和分子机制,2018/01-2020/12,180万,在研,参加
2. 上海交通大学医工交叉,16X190020041,GSK-3通过自噬调节血管性痴呆脑内β-淀粉样蛋白水平的研究, 2016/01-2018/12,21万元,在研,合作申请
3. 国家自然科学基金青年项目,81402950,新型EGFRvIII抑制剂对EGFRvIII+/PTEN null神经胶质瘤的抗肿瘤作用及机制研究,2015/01-2017/12,23万元,已结题,主持
4. 上海交通大学“晨星青年学者奖励计划”(B类),中药天然产物物质库靶向抗肿瘤药物筛选及其作用机理研究,2015/01-2017/12,15万元,在研,主持
5. 教育部留学回国人员启动基金, 15Z102050016, 新型EGFRvIII抑制剂抗神经胶质母细胞瘤的机制研究,2015/03-2017/12,3万元,在研,主持
6. 上海交通大学医工交叉,YG2014QN12,人羊膜上皮细胞调节颗粒细胞FHSR/EGFR信号通路促卵巢功能修复的作用机制研究,2015/01-2017/12,8万元,已结题,合作申请
7. 上海市浦江人才计划, 14PJ1404700,Akt磷酸化转录因子Pdx1调控胰岛素表达及其在糖尿病发病中的作用与机制研究,2014/07-2016/06,20万元,已结题,主持

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