师资队伍

张延

 

电话: 021-34206778
传真: 021-34206778
邮箱: yanzhang2006@sjtu.edu.cn
主页: http://glycolab.sjtu.edu.cn/

学习经历
1993-1996 博士 日本 东京大学
1991-1993 硕士 日本 东京大学
1982-1986 学士 山东大学 微生物学专业

 

工作经历
2006-至今 系统生物医学研究院 研究员
糖生物学与糖组学实验室 课题组长
中日(SCSB-AIST)医学糖组学联合实验室 中方主任
2004-2006 日本国立动物卫生研究所 特别研究员
1996-2004 日本产业技术综合研究所 助理研究员
1986-1989 上海交通大学生命科学与技术系 助教

 

人才奖项
上海交通大学三八红旗手(2018)
上海浦江人才(2007)

 

学会兼职与审稿人
上海交通大学生农医药学部学位委员
上海交通大学生命学院学位委员
中国生物化学与分子生物学会糖复合物专业委员会 常务委员
中国生物工程学会糖生物工程专业委员会 常务委员
中国生物化学与分子生物学会蛋白质组学专业委员会 委员
亚洲糖组学研究联盟(ACGG) 成员
江南大学糖化学与生物学技术教育部重点实验室 学术委员
Glycoconjugate Journal、Journal of Cellular and Molecular Medicine、Frontiers in Physiology、Plos One、Hepatoma Research、分析化学、生命的化学等杂志审稿人 国家自然基金委面上、重点项目评审专家
国家精准医学重大专项评审专家
教育部评审专家
上海市科委基金评审专家

本实验室聚焦蛋白质糖基化调控和疾病糖链变化;运用多组学技术手段,研究蛋白质糖基化和糖链在疾病发生发展中的功能;致力于基于糖链的疾病诊断,药物开发等转化医学研究。主要研究方向:

1. 蛋白质糖基化调控机制研究

2. 疾病糖蛋白糖链生物标志物及其功能糖组学技术

糖科学相关研究论文(* corresponding author)
1. Shan, A. D., Lu, J. S., Xu, Z. J., Li, X.; Xu, Y. J., Li, W., Liu, F., Yang, F., Sato,T., Narimatsu, H. *, Zhang, Y.* Polypeptide N-acetylgalactosaminyltransferase 18 non-catalytically regulates the ER homeostasis and O-glycosylation. BBA-General Subjects 2019, ,1863(5),870-882
2. Yan, X. L., Lu, J. S., Zou, X., Zhang, S., Cui, Y. L., Zhou, L. Q., Liu, F., Shan, A. D., Lu, J. Y., Zheng, M. H., Feng, B.*, Zhang, Y.* The polypeptide N-acetylgalactosaminyltransferase 4 exhibits stage-dependent expression in colorectal cancer and affects tumorigenesis, invasion and differentiation. Febs J 2018, 285, 3041-3055.
3. Xu, W. P.; Wang, Z. R.; Zou, X.; Zhao, C.; Wang, R.; Shi, P. M.; Yuan, Z. L.; Yang, F.; Zeng, X.; Wang, P. Q.; Sultan, S.; Zhang, Y.*; Xie, W. F.*, Serum Wisteria floribunda agglutinin-positive Mac-2-binding protein evaluates liver function and predicts prognosis in liver cirrhosis. J Dig Dis 2018, doi: 10.1111/1751-2980.12596.
4. Zhu, M. Y.; Chen, P. Z.; Li, J.; Yu, D. M.; Huang, D.; Zhu, X. J.; Han, Y.; Chen, J.; Huang, W.; Chen, Y. Y.; Gong, Q. M.; Jiang, J. H.; Zhang, D. H.; Zhang, Y.; Zhang, J. M.; Zhang, X. X., Serum M2BPGi level is a novel predictive biomarker for the responses to pegylated interferon-alpha treatment in HBeAg-positive chronic hepatitis B patients. J Medical Virol 2018, 90(4), 721-729.
5. 崔雅璐; 徐颖姣; 贾文娟; 杨芳; 张延*, 疾病及发育中多肽:N-乙酰氨基半乳糖转移酶ppGalNAc-T的重要性. 生命科学 2018, 30(11): 1264-1274
6. Liu, F.; Xu, K.; Xu, Z. J.; de las Rivas, M.; Wang, C. R.; Li, X.; Lu, J. S.; Zhou, Y. Y.; Delso, I.; Merino, P.; Hurtado-Guerrero, R.*; Zhang, Y.*; Wu, F.*, The small molecule luteolin inhibits N-acetyl--galactosaminyltransferases and reduces mucin-type O-glycosylation of amyloid precursor protein. J Biol Chem 2017, 292(52), 21304-21319.
7. Xu, Z. J.; Li, X.; Zhou, S. M.; Xie, W. X.; Wang, J.; Cheng, L.; Wang, S.; Guo, S. J.; Xu, Z. W.; Cao, X.; Zhang, M. H.; Yu, B. A.; Narimatsu, H.; Tao, S. C.*; Zhang, Y.*, Systematic identification of the protein substrates of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T1/T2/T3 using a human proteome microarray. Proteomics 2017, 17, (11).
8. 张芳; 许之珏; 徐颖姣; 邹霞; 张延*, IgG糖基化与疾病相关性研究进展. 生命科学 2017, 04, 319-330.
9. Zhang, S.; Lu, J.; Xu, Z.; Zou, X.; Sun, X.; Xu, Y.; Shan, A.; Lu, J.; Yan, X.; Cui, Y.; Yan, W.; Du, Y.; Gu, J.; Zheng, M.; Feng, B.*; Zhang, Y.*, Differential expression of ST6GAL1 in the tumor progression of colorectal cancer. Biochem Biophys Res Commun 2017, 486(4), 1090-1096.
10. Zou, X.; Zhu, M. Y.; Yu, D. M.; Li, W.; Zhang, D. H.; Lu, F. J.; Gong, Q. M.; Liu, F.; Jiang, J. H.; Zheng, M. H.; Kuno, A.; Narimatsu, H.; Zhang, Y.*; Zhang, X. X.*, Serum WFA+-M2BP levels for evaluation of early stages of liver fibrosis in patients with chronic hepatitis B virus infection. Liver Int 2017, 37(1), 35-44.
11. Zou, X.; Yoshida, M.; Nagai-Okatani, C.; Iwaki, J.; Matsuda, A.; Tan, B.; Hagiwara, K.; Sato, T.; Itakura, Y.; Noro, E.; Kaji, H.; Toyoda, M.; Zhang, Y.; Narimatsu, H.; Kuno, A., A standardized method for lectin microarray-based tissue glycome mapping. Sci Rep 2017, 7, 43560.
12. Xu, Y.; Pang, W.; Lu, J.; Shan, A.; Zhang, Y.*, Polypeptide N-Acetylgalactosaminy ltransferase 13 Contributes to Neurogenesis via Stabilizing the Mucin-type O-Glycoprotein Podoplanin. J Biol Chem 2016, 291(45), 23477-23488.
13. Zou, X.; Chi, X.; Pan, Y.; Du, D.; Sun, H.; Matsuda, A.; Li, W.; Kuno, A.; Zhang, X.; Narimatsu, H.; Niu, J.*; Zhang, Y.*, LecT-Hepa facilitates estimating treatment outcome during interferon therapy in chronic hepatitis C patients. Clin Proteomics 2014, 11(1), 44.
14. Tan, B.; Matsuda, A.; Zhang, Y.; Kuno, A.; Narimatsu, H., Multilectin-assisted fractionation for improved single-dot tissue glycome profiling in clinical glycoproteomics. Mol Biosyst 2014, 10 (2), 201-205.
15. Yu, D. M.; Li, X. H.; Mom, V.; Lu, Z. H.; Liao, X. W.; Han, Y.; Pichoud, C.; Gong, Q. M.; Zhang, D. H.; Zhang, Y.; Deny, P.; Zoulim, F.; Zhang, X. X., N-glycosylation mutations within hepatitis B virus surface major hydrophilic region contribute mostly to immune escape. J Hepatol 2014, 60(3), 515-522.
16. Zhang, X.; Zhang, Y.*, Applications of Azide-Based Bioorthogonal Click Chemistry in Glycobiology. Molecules 2013, 18(6), 7145-7159.
17. Zou, X.; Feng, B.; Dong, T. T.; Yan, G. Q.; Tan, B. B.; Shen, H.; Huang, A.; Zhang, X.; Zhang, M. H.; Yang, P. Y.; Zheng, M. H.; Zhang, Y.*, Up-regulation of type I collagen during tumorigenesis of colorectal cancer revealed by quantitative proteomic analysis. J Proteomics 2013, 94, 473-485.
18. Tan, B. B.; Qiu, Y. P.; Zou, X.; Chen, T. L.; Xie, G. X.; Cheng, Y.; Dong, T. T.; Zhao, L. J.; Feng, B.; Hu, X. F.; Xu, L. X.; Zhao, A. H.; Zhang, M. H.; Cai, G. X.; Cai, S. J.; Zhou, Z. X.; Zheng, M. H.; Zhang, Y.*; Jia, W.*, Metabonomics Identifies Serum Metabolite Markers of Colorectal Cancer. J Proteome Res 2013, 12(6), 3000-3009.
19. Aoki-Kinoshita, K. F.; Sawaki, H.; An, H. J.; Campbell, M.; Cao, Q. C.; Cummings, R.; Hsu, D. K.; Kato, M.; Kawasaki, T.; Khoo, K. H.; Kim, J.; Kolarich, D.; Li, X. Y.; Liu, M. Q.; Matsubara, M.; Okuda, S.; Packer, N. H.; Ranzinger, R.; Shen, H. L.; Shikanai, T.; Shinmachi, D.; Toukach, P.; Yamada, I.; Yamaguchi, Y.; Yang, P. Y.; Ying, W. T.; Yoo, J. S.; Zhang, Y.; Zhang, Y.; Narimatsu, H., The Fifth ACGG-DB Meeting Report: Towards an International Glycan Structure Repository. Glycobiology 2013, 23(12), 1422-1424.
20. Li, X.; Wang, J.; Li, W.; Xu, Y. J.; Shao, D.; Xie, Y. Y.; Xie, W. X.; Kubota, T.; Narimatsu, H.; Zhang, Y*., Characterization of ppGalNAc-T18, a member of the vertebrate-specific Y subfamily of UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalacto saminyltransferases. Glycobiology 2012, 22(5), 602-615.
21. Wang, S.; Xie, W. X.; Zhang, X.; Zou, X.; Zhang, Y.*, Disulfide- and terminal alkyne-functionalized magnetic silica particles for enrichment of azido glycopeptides. Chem Commun (Camb) 2012, 48(47), 5907-5909.
22. Du, D. N.; Zhu, X. J.; Kuno, A.; Matsuda, A.; Tsuruno, C.; Yu, D. M.; Zhang, Y.; Ikehara, Y.; Tanaka, Y.; Zhang, X. X.; Narimatsu, H., Comparison of LecT-Hepa and FibroScan for assessment of liver fibrosis in hepatitis B virus infected patients with different ALT levels. Clin Chim Acta 2012, 413(21-22), 1796-1799.
23. 王静; 彭灿; 张延*, O-糖基化起始糖基转移酶的活性与结构研究. 生命科学 2011, 07, 619-629.
24. Peng, C.; Togayachi, A.; Kwon, Y. D.; Xie, C. Y.; Wu, G. D.; Zou, X.; Sato, T.; Ito, H.; Tachibana, K.; Kubota, T.; Noce, T.; Narimatsu, H.; Zhang, Y.*, Identification of a novel human UDP-GalNAc transferase with unique catalytic activity and expression profile. Biochem Biophys Res Commun 2010, 402(4), 680-686.
25. Wang, S.; Zou, X.; Zhang, Y.*, Mass Spectrometry Based Analysis of Protein O-glycosylation. Prog Chem 2010, 22(12), 2428-2435.
26. Cheng, L. M.; Tachibana, K.; Iwasaki, H.; Kameyama, A.; Zhang, Y.; Kubota, T.; Hiruma, T.; Tachibana, K.; Kudo, T.; Guo, J. M.; Narimatsu, H., Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T15. FEBS Lett 2004, 566(1-3), 17-24.
27. Zhang, Y.; Iwasaki, H.; Wang, H.; Kudo, T.; Kalka, T. B.; Hennet, T.; Kubota, T.; Cheng, L. M.; Inaba, N.; Gotoh, M.; Togayachi, A.; Guo, J. M.; Hisatomi, H.; Nakajima, K.; Nishihara, S.; Nakamura, M.; Marth, J. D.; Narimatsu, H., Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine : polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen. J Biol Chem 2003, 278(1), 573-584.
28. Wang, H.; Tachibana, K.; Zhang, Y.; Iwasaki, H.; Kameyama, A.; Cheng, L. M.; Guo, J. M.; Hiruma, T.; Togayachi, A.; Kudo, T.; Kikuchi, N.; Narimatsu, H., Cloning and characterization of a novel UDP-GaINAc : polypeptide N-acetylgalactosaminyl transferase, pp-GaINAc-T14. Biochem Biophys Res Commun 2003, 300(3), 738-744.
29. Iwasaki, H.; Zhang, Y.; Tachibana, K.; Gotoh, M.; Kikuchi, N.; Kwon, Y. D.; Togayachi, A.; Kudo, T.; Kubota, T.; Narimatsu, H., Initiation of O-glycan synthesis in IgA1 hinge region is determined by a single enzyme, UDP-N-acetyl- alpha-D- galactosamine: Polypeptide N-acetylgalactosaminyltransferase 2. J Biol Chem 2003, 278(8), 5613-5621.
30. Guo, P.; Zhang, Y.; Zhang, X. Y.; Chen, H. L.; Zhang, Y.; Wang, H.; Narimatsu, H., Analysis of lewis antigens on cell surface and alpha1,3 fucosyltransferase subtypes in H7721 human hepatocarcinoma cells. J Exp Clin Cancer Res 2003, 22(1), 135-139.
31. Kudo, T.; Iwai, T.; Kubota, T.; Iwasaki, H.; Takayma, Y.; Hiruma, T.; Inaba, N.; Zhang, Y.; Gotoh, M.; Togayachi, A.; Narimatsu, H., Molecular cloning and characterization of a novel UDP-Gal : GaINAc alpha peptide beta 1,3-galactosyltransferase (ClGal-T2), an enzyme synthesizing a core 1 structure of O-glycan. J Biol Chem 2002, 277(49), 47724-47731.
32. Iwai, T.; Inaba, N.; Naundorf, A.; Zhang, Y.; Gotoh, M.; Iwasaki, H.; Kudo, T.; Togayachi, A.; Ishizuka, Y.; Nakanishi, H.; Narimatsu, H., Molecular cloning and characterization of a novel UDP-GlcNAc: GalNAc-peptide,beta 1,3-N-acetylgluco- saminyltransferase (beta 3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycans. J Biol Chem 2002, 277(15), 12802-12809.
33. Guo, J. M.; Zhang, Y.; Cheng, L. M.; Iwasaki, H.; Wang, H.; Kubota, T.; Tachibana, K.; Narimatsu, H., Molecular cloning and characterization of a novel member of the UDP-GalNAc : polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc- T12. FEBS Lett 2002, 524(1-3), 211-218.
34. Gotoh, M.; Sato T.; Akashima T.; Iwasaki H, Kameyama A, Mochizuki H, Yada T, Inaba N, Zhang Y.; Kikuchi N.; Kwon YD, Togayachi A, Kudo T, Nishihara S, Watanabe H.; Kimata K.; Narimatsu, H., Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesis. J Biol Chem 2002, 277(41), 38189-38196.
35. Cheng, L. M.; Tachibana, K.; Zhang, Y.; Guo, J.; Tachibana, K. K.; Kameyama, A.; Wang, H.; Hiruma, T.; Iwasaki, H.; Togayachi, A.; Kudo, T.; Narimatsu, H., Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T10. FEBS Lett 2002, 531(2), 115-121.

多组学和微生物学相关文章
36. Wang, X. S., Du, H., Zhang, Y., and Xu, Y. (2018) Environmental Microbiota Drives Microbial Succession and Metabolic Profiles during Chinese Liquor Fermentation. Appl Environ Microb 2018, 84.
37. Song, Z.; Du, H.; Zhang, Y.; Xu, Y., Unraveling Core Functional Microbiota in Traditional Solid-State Fermentation by High-Throughput Amplicons and Metatranscriptomics Sequencing. Front Microbiol 2017, 8, 1294.
38. Zhu, M. Y.; Zou, X.; Li, Q.; Yu, D. M.; Yang, Z. T.; Huang, D.; Chen, J.; Gong, Q. M.; Zhang, D. H.; Zhang, Y.; Chen, L.; Chen, P. Z.; Zhang, X. X., A novel noninvasive algorithm for the assessment of liver fibrosis in patients with chronic hepatitis B virus infection. J Viral Hepat 2017, 24(7), 589-598.
39. Xu, Z. J.; Wang, Z. X.; Yuan, C.; Liu, X. P.; Yang, F.; Wang, T.; Wang, J. L.; Manabe, K.; Qin, O.; Wang, X. M.; Zhang, Y.*; Zhang, M. H.*, Dandruff is associated with the conjoined interactions between host and microorganisms. Sci Rep 2016, 6, 24877.
40. Wang, Y.; Cao, Y. F.; Huang, X. Y.; Yu, T.; Wei, Z. Y.; McGrath, J.; Xu, F.; Bi, Y.; Li, X. W.; Yang, F. P.; Li, W. D.; Zou, X.; Peng, Z. H.; Xiao, Y. Z.; Zhang, Y.; He, L.; He, G., Allele-specific expression of mutated in colorectal cancer (MCC) gene and alternative susceptibility to colorectal cancer in schizophrenia. Sci Rep 2016, 6, 26688.
41. Lu, X. W.; Wu, Q.; Zhang, Y.; Xu, Y., Genomic and transcriptomic analyses of the Chinese Maotai-flavored liquor yeast MT1 revealed its unique multi-carbon co-utilization. BMC Genomics 2015, 16, 1064.
42. Kong, Y.; Wu, Q.; Zhang, Y.; Xu, Y., In Situ Analysis of Metabolic Characteristics Reveals the Key Yeast in the Spontaneous and Solid-State Fermentation Process of Chinese Light-Style Liquor. Appl Environ Microbiol. 2014, 80(12), 3667-3676.
43. Zhu, X. J.; Gong, Q. M.; Yu, D. M.; Zhang, D. H.; Gu, L. L.; Han, Y.; Chen, J.; Zhang, Y.; Zhang, X. X., Early serum hepatitis B virus large surface protein level: A stronger predictor of virological response to peginterferon alfa-2a than that to entecavir in HBeAg-positive patients with chronic hepatitis B. J Clin Virol 2013, 57(4), 318-322.
44. Cheng, Y.; Xie, G. X.; Chen, T. L.; Qiu, Y. P.; Zou, X.; Zheng, M. H.; Tan, B. B.; Feng, B.; Dong, T. T.; He, P. A.; Zhao, L. J.; Zhao, A. H.; Xu, L. X.; Zhang, Y.*; Jia, W.*, Distinct Urinary Metabolic Profile of Human Colorectal Cancer. J Proteome Res 2012, 11(2), 1354-1363.
45. Zhang, X. W.; Yan, X. J.; Zhou, Z. R.; Yang, F. F.; Wu, Z. Y.; Sun, H. B.; Liang, W. X.; Song, A. X.; Lallemand-Breitenbach, V.; Jeanne, M.; Zhang, Q. Y.; Yang, H. Y.; Huang, Q. H.; Zhou, G. B.; Tong, J. H.; Zhang, Y.; Wu, J. H.; Hu, H. Y.; de The, H.; Chen, S. J.; Chen, Z., Arsenic Trioxide Controls the Fate of the PML-RAR alpha Oncoprotein by Directly Binding PML. Science 2010, 328(5975), 240-243.
46. Zhang, Q. Y.; Mao, J. H.; Liu, P.; Huang, Q. H.; Lu, J.; Xie, Y. Y.; Weng, L.; Zhang, Y.; Chen, Q.; Chen, S. J.; Chen, Z., A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia. Proc Natl Acad Sci U S A 2009, 106(9), 3378-3383.
47. Li, M.; Wang, B. H.; Zhang, M. H.; Rantalainen, M.; Wang, S. Y.; Zhou, H. K.; Zhang, Y.; Shen, J.; Pang, X. Y.; Zhang, M. L.; Wei, H.; Chen, Y.; Lu, H. F.; Zuo, J.; Su, M. M.; Qiu, Y. P.; Jia, W.; Xiao, C. N.; Smith, L. M.; Yang, S. L.; Holmes, E.; Tang, H. R.; Zhao, G. P.; Nicholson, J. K.; Li, L. J.; Zhao, L. P., Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci U S A 2008, 105(6), 2117-2122.
48. Wei, H.; Shen, J.; Pang, X.; Ding, D.; Zhang, Y.; Zhang, B.; Lu, H.; Wang, T.; Zhang, C.; Hua, X.; Cui, L.; Zhao, L., Fatal infection in human flora-associated piglets caused by the opportunistic pathogen Klebsiella pneumoniae from an apparently healthy human donor. J Vet Med Sci 2008, 70(7), 715-717.
49. Zhang, M. L.; Liu, B. Y.; Zhang, Y.; Wei, H.; Lei, Y. F.; Zhao, L. P., Structural shifts of mucosa-associated lactobacilli and Clostridium leptum subgroup in patients with ulcerative colitis. J Clin Microbiol 2007, 45(2), 496-500.
50. Li, K.; Guan, W.; Wei, G.; Liu, B.; Xu, J.; Zhao, L.; Zhang, Y.*, Phylogenetic analysis of intestinal bacteria in the Chinese mitten crab (Eriocheir sinensis). J Appl Microbiol 2007, 103(3), 675-682.
51. Shen, J.; Zhang, B. R.; Wei, G. F.; Pang, X.; Wei, H.; Li, M.; Zhang, Y.; Jia, W.; Zhao, L. P., Molecular profiling of the Clostridium leptum subgroup in human fecal microflora by PCR-denaturing gradient gel electrophoresis and clone library analysis. Appl Environl Microbiol 2006, 72(8), 5232-5238.
52. Hagiwara, H.; Kunihiro, S.; Nakajima, K.; Sano, M.; Masaki, H.; Yamamoto, M.; Pak, J. W.; Zhang, Y.; Takase, K.; Kuwabara, I.; Maruyama, I. N.; Machida, M., Affinity selection of DNA-binding proteins from yeast genomic DNA libraries by improved lambda phage display vector. J Biochem 2002, 132(6), 975-982.
53. Zhang, Y.; Pak, J. W.; Maruyama, I. N.; Machida, M., Affinity selection of DNA-binding proteins displayed on bacteriophage lambda. J Biochem 2000, 127(6), 1057-1063.
54. Nakajima, K.; Kunihiro, S.; Sano, M.; Zhang, Y.; Eto, S.; Chang, Y. C.; Suzuki, T.; Jigami, Y.; Machida, M., Comprehensive cloning and expression analysis of glycolytic genes from the filamentous fungus, Aspergillus oryzae. Curr Genet 2000, 37(5), 322-327.
55. Zhang, Y.; Arai, H.; Sambongi, Y.; Igarashi, Y.; Kodama, T., Heterologous expression of Hydrogenobacter thermophilus cytochrome c-552 in the periplasm of Pseudomonas aeruginosa. J Ferment Bioeng 1998, 85(3), 346-349.
56. Kimura T., Zhang, Y., Kodama, T., Omori T., Isolation and characterization of Tn 5-induced mutants deficient in carbazole catabolism. FEMS Microbiol Lett 1996, 135, 65-70.
57. Arai H., Zhang, Y., Sambongi Y., Igarashi Y., Kodama T., Production of Recombinant Cytochrome c-551 in a Pseudomonas aeruginosa Mutant Strain. J Ferment Bioeng 1995, 79(5), 489-492.
58. Ouchiyama, N.; Zhang, Y.; Omori, T.; Kodama, T., Biodegradation of Carbazole by Pseudomonas spp. CA06 and CA10. Biosci, Biotechnol, Biochem 1993, 57(3), 455-460.

学术书籍:
1.《糖组学手册》中文导读 科学书版社 2011年6月第一版
2.《2012-2013生物化学与分子生物学学科发展报告》 参编 中国科学技术出版社 2014年4月第一版

1. 国家自然科学基金面上项目,31770850,神经特异性O-GalNAc糖基转移酶在内质网中的功能机制研究,2018.01-2021.12,项目负责人
2. 国家科技重大专项课题“艾滋病和病毒性肝炎等重大传染病防治”专项,2018ZX10302205,乙肝相关肝癌异常糖链糖蛋白的新型凝集素识别技术开发与临床精准检测应用,2018.01-2020.12,子任务负责人
3. 国家自然科学基金面上项目,31570796,蛋白质O-GalNAc糖基化抑制剂的分子机制研究,2016.01-2019.12,项目负责人
4. 上海交通大学科技创新专项资金-多学科交叉项目培育(医工),YG2015ZD14,肺部GGN患者血清中免疫相关糖蛋白糖型的生物标志物研究,2016.01-2018.12,共同首席
5. 国家自然科学基金面上项目,31370806,内质网中ppGalNAc-T18的功能机制研究,2014.01-2017.12,项目负责人
6. 教育部/博士点基金博导类项目,20130073110088,O-糖基转移酶ppGalNAc-T13在神经分化中的功能机制研究,2014.01-2016.12,项目负责人
7. 国家国际科技合作政府间项目,2012DFG32190,基于糖链生物标志物的疾病早期诊断新技术,2012.06-2015.05,项目负责人
8. 上海市科委国际科技合作项目,12410707200,基于糖链生物标志物的疾病早期诊断新技术,2012.10-2014.09,项目负责人
9. 国家外专局高端外国专家项目,GDW20133100078,成松久教授,2013.04-2016.03
10. 国家重点基础研究发展计划973前沿,2012CB822103,糖链对肿瘤细胞生物学行为的影响及机制研究,2012.01-2016.08,课题子任务负责人
11. 国家高技术研究发展计划863计划,2012AA020203,凝集素芯片开发与糖链结构验证,2012.01-2015.12,子课题负责人
12. 国家自然科学基金面上项目,31170771,胞浆或核定位蛋白质的O-GalNAc糖基化研究,2012.01-2015.12,项目负责人
13. 上海市科委项目医学重点合作课题,11411950700,结直肠癌早期诊断糖基化蛋白标志物的寻找,2011.11-2014.09
14. 国家自然科学基金面上项目,30970642,P19细胞神经分化相关ppGalNAc-T13的功能解析,2010.01-2012.12,项目负责人
15. 上海市科委上海市白玉兰科技人才基金,疾病相关的糖组学研究,2010.06-2011.05,项目负责人
16. 国家自然科学基金面上项目,30770482,ppGalNAc-T在肺癌中的功能研究,2008.01-2010.12,项目负责人
17. 国家重点基础研究发展计划973蛋白质重大项目,2007CB914703,疾病以及药物治疗下蛋白质表达谱及其与代谢表达谱的相关性研究,2007.07-2011.08,课题负责人
18. 上海市科委浦江人才计划,07pj14057,多肽N乙酰氨基半乳糖基转移酶在肿瘤发生发展中的功能研究,2007.09-2009.10,项目负责人
19. 教育部留学回国人员科研启动基金,ppGalNAc-T在肺癌发生发展中的作用机理,2008.10-2009.10,项目负责人
20. 中日医学糖组学联合实验室合作项目, 项目负责人

1. 张延, 张芳, 许之珏, 杨芳, 邹霞, 姚烽, 赵珩。血清免疫球蛋白G糖链修饰在肺部磨玻璃结节早期诊断中的用途。专利申请号:CN201711070938.0
2. 邹霞,张延,杨芳,冯波,郑民华。CTx在制备诊断结直肠癌药物中的用途。中国,发明专利,专利号:ZL201310476530.9
3. 张延,王胜,谢文娴。富集叠氮标记生物大分子的磁性纳米材料及其制备与应用。中国,发明专利,专利号:ZL201110236722.3
4. 张延,庞文杰。一种针对ppGalNAc-T13多克隆抗体的特异性抗原肽及其制备与应用。中国,发明专利,专利号:ZL201110236821.1
5. 张延,彭灿,武功冬,邹霞,谢文娴。ppGalNAc-T20抗原及其多克隆抗体的制备方法。中国,发明专利,专利号:ZL201010300097.X
6. 成松久、张延。N-乙酰氨基半乳糖胺转移酶的突变体。日本,发明专利,专利号:4251402

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