师资队伍

吴方

 

电话: 021-34207545
传真:
邮箱: fang.wu@sjtu.edu.cn
主页: ysl.sjtu.edu.cn

学习经历
1995年-1999年,上海交通大学生物技术系;理学学士学位
1999年-2002年,中国科学院上海生命科学学院生物工程研究中心;理学硕士学位
2003年-2007年,瑞士苏黎世大学生物化学系;自然科学博士学位,主要进行酶的过渡态类似物抑制剂的设计与机理研究

 

工作经历
2002年-2003年,瑞士诺华制药公司巴塞尔总部临床前安全部门;药物研发工作
2007年-2008年,瑞士巴塞尔大学有机化学系;博士后研究,主要进行基于银离子的纳米抗菌素的研究
2008年-2010年,瑞士联邦理工大学脑思维研究所;博士后研究,主要从事老年痴呆症疾病机理和其抑制剂的研究,并负责与瑞士雀巢公司总部的项目合作。
2011年1月-现在,上海交通大学系统生物医学研究院,研究员
2011年1月-现在 上海交通大学致远学院基地班本科生遗传学课程的授课教师

 

人才奖项
2012年上海市“浦江学者”

 

学会兼职与审稿人
Nature集团SCI期刊Scientific Reports杂志编委

主要研究领域和方向:1. 高通量筛选模型;小分子药物的设计、发现、分子机制和细胞作用机理研究 2. 酶的化学生物学研究 3. 新型跨膜信号转导通路的发现

1. Youtian Hu#, Lu Wang#, Xu Han#, Yueyang Zhou, Tonghui Zhang, Li Wang, Ting Hong, Wei Zhang, Xun-Xiang Guo, Jielin Sun, Yingxin Qi, Jing Yu*, Hong Liu*, Fang Wu*.Discovery of a Bioactive Inhibitor with a New Scaffold for Cystathionine γ-Lyase. Journal of Medicinal Chemistry, 2018 Dec 18.

2. Li Wang#, Hao Cai#, Youtian Hu, Fan Liu, Shengshuo Huang, Yueyang Zhou, Jing Yu*, Jinyi Xu* and Fang Wu*. A pharmacological probe identifies cystathionine β-synthase as a new negative regulator for ferroptosis. Cell Death & Disease, 2018 Sept 26.

3. Youtian Hu#, Juan Feng, Fang Wu*. The Multiplicity of Polypeptide GalNAc-Transferase: Assays, Inhibitors and Structures. ChemBioChem, 2018 Aug 27.

4. Zhixue Du#, Jing Yu#, Fucai Li, Liyun Deng, Fang Wu, Xiangyi Huang, Jan Bergstrand, Jerker Widengren, Chaoqing Dong, and Jicun Ren. In Situ Monitoring of p53 Protein and MDM2 Protein Interaction in Single Living Cells Using Single-Molecule Fluorescence Spectroscopy. Anal Chem, 2018 May 15;90(10):6144-6151.

5. 王莉#, 周越洋, 吴方*. 胱硫醚β合酶天然产物抑制剂的高通量筛选[J]. 生物技术, 2017(2):167-173.

6. Feng Liu#, Kai Xu#, Zhijue Xu, Matilde de las Rivas, Congrong Wang, Xing Li, Jishun Lu, Yueyang Zhou, Ignacio Delso, Pedro Merino, Ramon Hurtado-Guerrero*, Yan Zhang* and Fang Wu*. The small molecule luteolin inhibits N-acetyl-α-galactosaminyltransferases and reduces mucin-type O-glycosylation of amyloid precursor protein[J]. Journal of Biological Chemistry, 2017, 292:jbc.M117.814202.

7. Hermeto Gerber#, Fang Wu#, Mitko Dimitrov , Guillermo M. Garcia Osuna , and Patrick C. Fraering. Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production. Journal of Biological Chemistry, 2017: jbc. M116. 754101.

8. Yinzhong Lu, Jun Wan#, Zhifeng Yang#, Xiling Lei, Qi Niu, Lanxin Jiang, Willemijn M. Passtoors, Aiping Zang, Patrick C. Fraering, and Fang Wu*. Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells. The FASEB Journal, 2016: fj. 201600702R.

9. ShuyangXu#, XianminZhu#, Hong Li#, Youtian Hu, JinpingZhou, Di He, Yun Feng, Lina Lu, Guizhen Du, Youjin Hu, Tiancheng Liu, ZhenWang, Guohui Ding, JiayuChen, ShaorongGao, Fang Wu, ZhigangXue, Yixue Li & Guoping Fan. The 14th Ile residue is essential for Leptin function in regulating energy homeostasis in rat. Scientific Reports, 2016 Jul 5;6:28508.

10. Shengtao Xu, Shanshan Lu, Hong Yao, Hao Cai, Xiaoming Miao, Fang Wu*, Dong-Hua Yang, Xiaoming Wu, Weijia Xie, Hequan Yao, Zhe-sheng Chen, Jinyi Xu. Probing the Anticancer Action of Oridonin with Fluorescent Analogues: Visualizing Subcellular Localization to Mitochondria. J Med. Chem. 2016

11. Xiling Lei#, Jing Yu#, Qi NIu, Jianhua Liu, Patrick C. Fraering and Fang Wu*. The FDA-approved natural product dihydroergocristine reduces the production of Alzheimer's disease amylod-abeta peptides. Scientific Reports 2015 5:16541

12. 钮琦#, 吴方*. Notch信号通路体外和细胞的药物筛选模型的建立和研究[J]. 药学学报, 2014(6):837-842.

13. Jie Ren, Yuanyuan Zhang, Huizi Jin, Jing Yu, Yueyang Zhou, Fang Wu* and Weidong Zhang.Novel Inhibitors of Human DOPA Decarboxylase Extracted from Euonymus glabra Roxb.ACS Chem Biol. 2014 9(4) 897-903. Cover Story ( IF: 5.4,上海交大SCI B类期刊)

Cited by Sina.com, 文汇报, 中国日报, 京华时报, 中国科学报, Sciencenet.com, 163.com, chinanews.com, bioon.com, ebiotrade.com等

14. Hilal A. Lashuel, Simona Eleuteri, Saviana Di Giovanni, Edward Rockenstein, Mike Mante, Antony Adame, Margarita Trejo, Fang Wu, Patrick C. Fraering, Eliezer Masliah. Novel Mechanism-based Inhibitors of Ab Aggregation and Toxicity. Neurobiology of Aging 2014:35(3) 720–721

15. Yueyang Zhou#, Jing Yu#, Xiling Lei, Jianying Wu, Qi Niu, Yixuan Zhang, Hong Liu, Philipp Christen, Heinz Gehring and Fang Wu*. High-throughput tandem-microwell assay identifies inhibitors of hydrogen sulfide signaling pathway. Chem Commun. 2013, 49, 11782-84. (IF: 6.7,上海交大SCI A类期刊)

16. Fang Wu, Philipp Christen, Heinz Gehring. A novel approach to inhibit intracellular vitamin B6-dependent enzymes: proof of principle with human and plasmodium ornithine decarboxylase and human histidine decarboxylase. FASEB J. 25 (2011), 2109-2122

博士后和博士期间:

1. Fang Wu, Claude Schweizer, Nikita Rudinskiy, David M. Taylor, Aleksey Kazantsev, Ruth Luthi-Carter and Patrick C. Fraering. Novel g-secretase inhibitors uncover a common nucleotide-binding site in JAK3, SIRT2 and PS1. FASEB J. 24 (2010), 2464-74

2. Fang Wu and Heinz Gehring.Structural requirements for novel coenzyme-substrate derivatives to inhibit intracellular human ornithine decarboxylase and cell proliferation. FASEB J. 23 (2009), 565-74

3. Ingrid B.Müller#, Fang Wu#, Bärbel Bergmann, Julia Knöckel, Rolf D. Walter, Heinz Gehring, Carsten Wrenger. Poisoning pyridoxal 5- phosphate (PLP)-dependent enzymes: A new strategy to target the malaria parasite Plasmodium falciparum. PloS ONE 4 (2009), e4406. Highlighted by peers in Faculty1000 Biology Pharmacology & Drug Discovery section. Hanjo Hellmann: Faculty of 1000 Biology, 16 Feb 2009 http://www.f1000biology.com/ article/id/ 1148087 /evaluation

4. Fang Wu, Jing Yu and Heinz Gehring. Inhibitory and structural studies of novel coenzyme-substrate analogs of human histidine decarboxylase. FASEB J. 22 (2008), 890-7

5. Fang Wu, Doris Grossenbacher and Heinz Gehring. Transition state based-inhibitor of human ornithine decarboxylase inhibiting growth of tumor cells. Molecular Cancer Therapeutics, 6 (2007), 1831-9

先后获国家自然科学基金面上项目2项、青年项目1项、重点子项目1项、973子项目1项、澳大利亚墨尔本大学国际合作项目1项等

获8项中国专项、2项英国专利授权

培养研究生10余名

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