学习经历
2001-2006 理学博士 中科院大连化学物理研究所、中科院上海有机化学研究所（联合培养）
1997-2001 理学学士 南开大学化学系

 

工作经历
2018.04 起 上海交通大学 系统生物医学研究院 特别研究员、博士生导师、课题组组长
2015.11-2017.11 美国Scripps研究所 分子医学系 Staff Scientist
2010.01-2015.10 美国Scripps研究所 化学生理系 Research Associate
2006.11-2010.01 加拿大Alberta大学 化学系、加拿大国家糖组学中心 博士后

2013.09-2014.08 美国Cassia LLC生物技术公司 课题负责人
2010.01-2011.10 美国功能糖组学协会（CFG） 糖芯片组负责人

 

人才奖项
2013 获美国NIH的SBIR基金资助（$1.3M）

 

学会兼职与审稿人
中国生物化学与分子生物学会糖复合物专业委员会 青年委员
J Org Chem, ACS Chem Biol, Eur J Med Chem, Carbohyd. Res等杂志审稿人

本实验室结合化学生物学、细胞生物学和分子生物学等技术手段，研究糖链在免疫调节和人类疾病中的生物学功能意义，致力于糖链在转化医学和精准治疗等方面的药物开发。主要研究方向为：
1． 糖链在流行病毒学中的生物学意义
2． 发展基于糖链-凝集素轴免疫检查点的免疫治疗新方案
3． 新型功能糖芯片在糖生物/糖组学研究中的应用

PUBLICATIONS (# indicates equal contribution)

37. Zhiqiang Hao#, Qiang Guo#, Wenjie Peng*, Lintai Da*. Kinetic Model Reveals the Critical Gating Motifs for Donor-Substrate Loading into Actinobacillus pleuropneumoniae N-glycosyltransferase. Phy Chem Chem Phy 2024, accepted.

36. Andrew J. Thompson, Nicholas C. Wu, Angeles Canales, Chika Kikuchi, Xueyong Zhu, Beatriz Fernández de Toro, Francisco J. Cañada, Charli Worth, Shengyang Wang, Ryan McBride, Wenjie Peng, Corwin M. Nycholat, Jesús Jiménez-Barbero, Ian A. Wilson, James C. Paulson; Evolution of human H3N2 influenza virus receptor specificity has substantially expanded the receptor-binding domain site. Cell Host Microbe 2024, 261-275.

35. Zhiqiang Hao#, Qiang Guo#, Yuanyuan Feng, Zihan Zhang, Tiantian Li, Zhixin Tian, Jianting Zheng, Lin-Tai Da* and Wenjie Peng*; Investigation of the Catalytic Mechanism of a Soluble N-glycosyltransferase Allows Synthesis of N-glycans at Noncanonical Sequons. JACS Au 2023, 2144-2155.

34. Yingyan Yu* and Wenjie Peng*; Recent progress in targeting the sialylated glycan-SIGLEC axis in cancer immunotherapy. Cancer Biol Med 2023, 369.

33. Hua Guo, Ang Li, Hao-Feng Lin, Meiqin Liu, Jing Chen, Tingting Jiang, Bei Li, Yi Wang, Michael Letko, Wenjie Peng*, and Zheng-Li Shi*; The glycan-binding trait of Sarbecovirus spike N-terminal domain reveals an evolutionary foot-prints. J Virol 2022, jvi.00958-22.

32. Xin Zhou; Qing Long; Dongwei Li; Jingru Gao; Qikai Sun; Shaozi Sun; Yong Su; Peng Wang; Wenjie Peng*; Ming Li*; Convergent Synthesis of Branched β-Glucan Tridecasaccharides Ready for Conjugation. Synthesis 2021, 2435.

31. Sander Herfst#; Jie Zhang#; Mathilde Richard; Ryan McBride; Pascal Lexmond; Theo M. Bestebroer; Monique I.J. Spronken; Dennis de Meulder; Judith M. van den Brand; Miruna E. Rosu; Stephen R. Martin; Steve J. Gamblin; Xiaoli Xiong; Wenjie Peng; Rogier Bodewes; Erhard van der Vries; Albert D.M.E. Osterhaus; James C. Paulson; John J. Skehel; Ron A.M. Fouchier*. Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Influenza Virus between Mammals. Cell Host & Microbe 2020, 602-613.

30. de Toro B#, Peng W#, Thompson A, Dominguez G, Canada J, Perez-Castells J, Paulson J*, Jimenez-Barbero J*, Canales A*. New NMR Avenues to Characterize the Interactions of Extended N-glycans with Proteins: The Influenza Hemagglutinin Case. Angew Chem Int Engl Ed 2018, 15051.

29. Imai H, Dinis J, Zhong G, Moncla L, Lopes T, Mcbride R, Thompson A, Peng W, Le M, Hanson A, Lauck M, Sakai-Tagawa Y, Yamada S, Eggenberger J, O’Connor D, Suzuki Y, Hatta M, Paulson J, Neumann G, Friedrich T, Kawaoka Y. Diversity of Influenza A(H5N1) Viruses in Infected humans, Northern Vietnam, 2004-2010. Emerging Infectious Diseases 2018, 1128-1238.

28. Peng W, Bouwman KM, McBride R, Grant OC, Woods RJ, Verheije MH, Paulson JC, de Vries RP. Enhanced human-type receptor binding by ferret transmissible H5N1 with a K193T mutation. J Virol. 2018, 92(10): e02016-17.

27. Peng W, Paulson JC. CD22 Ligands on a Natural N-Glycan Scaffold Efficiently Delivers Toxins to B-Lymphoma Cells. J Am Chem Soc. 2017, 139(36):12450-12458.

26. Peng W*, de Vries RP* (equiv. contribution), Grant OC, Thompson A, McBride R, Tsogtbaatar B, Lee PS, Razi N, Wilson IA, Woods RJ, Paulson JC. Recent H3N2 Viruses Have Evolved for Extended Branched Human-type Receptors Conferring Potential for Increased Avidity. Cell Host & Microbe 2017, 21, 23-34.

25. de Vries RP*, Peng W* (equal contribution), Grant OC, Thompson AJ, Zhu XY, Bouwman KM, de la Pena ATT, van Breemen MJ, Ambepitiya Wichramasinghe IN, de Haan CAM, Yu W, McBride R, Sanders RW, Woods RJ, Verheije MH, Wilson IA, Paulson JC. Three Mutations Switch H7N9 Influenza to Human-type Receptor Specificty. Plos Pathogens 2017, 13(6): e1006390.

24. Li W, Hulswit RJG, Widjaja I, Raj VS, McBride R, Peng W, Widagdo W, Tortorici MA, van Dieren B, Lang Y, van Lent JWM, Paulson JC, de Haan CAM, de Groot RJ, van Kuppeveld FJM, Haagmans BL, Bosch BJ. Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein. Proc Natl Acad Sci U S A. 2017,114(40): E8508-E8517.

23. de Vries RP*, Tzarum N*, Peng W* (equal contribution), Thompson AJ*, Ambepitiya Wickramasinghe IN, de la Pena ATT, van Breemen MJ, Bouwman KM, Zhu X, McBride R, Yu W, Sanders RW, Verheije MH, Wilson IA, Paulson JC. A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human-type receptors. EMBO Mol Med. 2017, 9(9):1314-1325.

22. Tzarum N, McBride R, Nycholat CM, Peng W, Paulson JC, Wilson IA. Unique Structural Features of Influenza H15 HA. J Virol 2017, e00046-17.

21. Tzarum N, de Vries RP, Peng W, Thompson A, Bouwman K, McBride R, Yu W, Zhu X, Verheije M, Paulson J, Wilson I. The 150-loop Restricts the Host Specificity of Human H10N8 Influenza Virus. Cell Reports 2017, 235-245.

20. Dai MD, Mcbride R, Dortmans J, Peng W, Bakkers M, van Kuppeveld F, Paulson J, de Vries E, de Haan C. Mutation of the 2nd Sialic Acid-Binding Site Resulting in Reduced Neuraminidase Activity Preceded Emergence of H7N9 Influenza A Virus. J. Virol. 2017, e00049-17.

19. Guo H, de Vries E, Mcbride R, Dekkers J, Peng W, Bouwman K, Nycholat C, Verheije H, Paulson J, van Kuppeveld F, de Haan C. Highly Pathogenic Influenza A(H5Nx) Viruses with Altered H5 Receptor-Binding Specificity. Emerg Infect Dis 2017, 23, 220-231.

18. Hiono T, Okamatsu M, Igarashi M, McBride R, de Vries RP, Peng W, Paulson JC, Sakoda Y, Kida H. (2015) Amino acid residues at positions 222 and 227 of the hemagglutinin together with the neuraminidase determine binding of H5 avian influenza viruses to sialyl Lewis X. J Arch Virol. 2015, 161(2):307-316.

17. Macauley MS, Kawasaki N, Peng W, Wang SH, He Y, Arlian BM, McBride R, Kanagi R, Khoo KH, Paulson JC. Unmasking of CD22 on germinal center B-cells occurs by alternative mechanisms in mouse and man. J Biol Chem. 2015;290(50):30066-77.

16. Ambepitiya WI, de Vries RP, Weerts EA. van Beruden SJ, Peng W, McBride R, Ducatez M, Guy J, Brown P, Eterradossi N, Grone A, Paulson JC, Verheije MH. Novel receptor specificity of avian gammacoronaviruses That Cause Enteritis. J Virol. 2015, 89, 8783.

15. Blattner C, Lee JH, Sliepen K, Derking R, Falkowska E, de la Peña AT, Cupo A, Julien JP, van Gils M, Lee PS, Peng W, Paulson JC, Poignard P, Burton DR, Moore JP, Sanders RW, Wilson IA, Ward AB. Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers. Immunity 2014, 40:669-680.

14. Nycholat C*, Peng W* (equal contribution), McBride R, Antonopoulos A, de Vries RP, Polonskaya Z, Finn MG, Dell A, Haslam SM, Paulson JC. Synthesis of biologically active N- and O-linked glycans with multi-sialylated poly-N-acetyllactosamine extensions using P. damsela alpha 2,6-sialyltransferase. J Am Chem Soc 2013, 135: 18280-18283.

13. Wang Z, Chinoy Z, Ambere S, Peng W, McBride R, de Vries RP, Glushka J, Paulson JC, Boons G. A general strategy for the chemoenzymatic synthesis of asymmetrically branched N-glycans. Science 2013; 341(6144):379-83.

12. Peng W, Zou L, Bhamidi S, McNeil MR, Lowary TL. The galactosamine residue in mycobacterial arabinogalactan is alpha-linked. J Org Chem. 2012, 77(21):9826-32.

11. Peng W, Pranskevich J, Nycholat C, Gilbert M, Wakarchuk W, Paulson JC, Razi N. Helicobacter pylori beta1,3-N-acetylglucosaminyltransferase for versatile synthesis of type 1 and type 2 poly-LacNAcs on N-linked, O-linked and I-antigen glycans. Glycobiology. 2012, 22(11):1453-64.

10. Nycholat CM, McBride R, Ekiert DC, Xu R, Rangarajan J, Peng W, Razi N, Gilbert M, Wakarchuk W, Wilson IA, Paulson JC. Recognition of sialylated poly-N-acetyllactosamine chains on N- and O-linked glycans by human and avian influenza A virus hemagglutinins. Angew Chem Int Ed Engl. 2012, 51(20):4860-3.

9. Peng W, Jayasuriya AB, Imamura A, Lowary TL. Synthesis of the 6-O-methyl-D-glycero-alpha-L-gluco-heptopyranose moiety present in the capsular polysaccharide from Campylobacter jejuni NCTC 11168. Org Lett. 2011, 13(19):5290-3.

8. Peng W, Tang P, Hu X, Liu JO, Yu B. Synthesis of the A,B-ring-truncated OSW saponin analogs and their antitumor activities. Bioorg Med Chem Lett. 2007, 17(20):5506-9.

7. Zhu C, Peng W, Li Y, Han X, Yu B. Synthesis of 3-O-(beta-D-xylopyranosyl-(1-->2)-beta-D-glucopyranosyl)-3'-O-(beta-D-gluc opyranosyl)tamarixetin, the putative structure of aescuflavoside A from the seeds of Aesculus chinensis. Carbohydr Res. 2006, 341(8):1047-51.

6. Peng W, Han X, Yu B. Synthesis of C-Aryl-flavonoid Derivatives via Suzuki-Miyaura Coupling Reaction. Chinese J Chemistry. 2006, 24(9):1154-62.

5. Peng W, Li Y, Zhu C, Han X, Yu B. Synthesis of tamarixetin and isorhamnetin 3-O-neohesperidoside. Carbohydr Res. 2005, 340(10):1682-8.

4. Li Y, Jiang Y, Yan XP, Peng WJ, Wu YY. A flow injection on-line multiplexed sorption preconcentration procedure coupled with flame atomic absorption spectrometry for determination of trace lead in water, tea, and herb medicines. Anal Chem. 2002, 74(5):1075-80.

3. Peng W, Sun J, Lin F, Han X, Yu B. Facile Synthesis of Ginsenoside Ro. Synlett. 2004, 2:259-62.

2. Peng W, Han X, Yu B. Synthesis of a Typical Glucuronide-Containing Saponin, 28-O-β-D-Glucopyranosyl Oleanate 3-O-β-D-Galactopyranosyl-(1→2)- [β-D-glucopyranosyl-(1→3)]-β-D-glucuronopyranoside. Synthesis. 2004, 10:1641-47.

1. Lin F, Peng W, Xu W, Han X, Yu B. A facile preparation of uronates via selective oxidation with TEMPO/KBr/Ca(OCl)2 under aqueous conditions. Carbohydr Res. 2004, 339(6):1219-23.

BOOK CHAPTER
1. Peng W, Nycholat CM, Razi N. Glycan Microarray Screening Assay for Glycosyltransferase Specificities. In Glycosyltransferases: Methods and Protocols (Methods in Molecular Biology book series, 2013 edition); Inka Brockhausen; Humana Press, Springer Science (June 30, 2013); ISBN-13: 978-1627034647

2. Jayasuiya AB, Peng W, Lowary TL. Ethyl 1-thio--D-galactofuranoside. In Carbohydrate Chemistry: Proven Synthetic Methods (Volume 3); Rene Roy, Sebastien Vidal; CRC Press (January 5, 2015); ISBN 9781466583573-CAT# K18997.

6. 上海市科委面上项目，2023.04-2026.03，项目负责人
5. 上海交通大学医工交叉重点项目，2022.01-2024.12，共同主持
4. 上海交通大学“基础研究特区计划”，2021.11-2024.10，子课题负责人
3. 国家自然科学基金面上项目，2022.01-2025.12，项目负责人
2. 国家自然科学基金面上项目，2020.01-2023.12，项目负责人
1. 国家自然科学基金重大研究计划，2019.01-2021.12，项目负责人

1. “Synthesis of glucuronide oleanane-type triterpene saponin with bisdesmoside” B. Yu, W. Peng, F. Lin, CN 1295246 C
2. “Synthesis and application of Ornithogalum saundersiae saponin OSW 1 two-ring analog without A and B rings” B. Yu, W. Peng, CN 101089008 B

博士生：
郭强（2018级），李甜甜（2019级），胡帅（2023级）

硕士生：
蒋翠萍（2021级），高英东（2021级），张舒琪（2022级），赵茜（2022级）

Alumni
Shrawan Ratan Chavan (博士后)，王姝垚（博士后），黄犇（2019级硕士）