学习经历
1981年9月至1986年7月 南京医科大学医疗系学习，获学士学位
1988年9月至1991年7月 南京医科大学内科（血液学专业）硕士研究生，获硕士学位
1995年9月至1998年7月 上海第二医科大学血液学研究所博士研究生，获博士学位

 

工作经历
2013年4月-迄今 上海交通大学系统生物医学研究院常务副院长、教育部系统生物医学重点实验室主任
2014年4月-迄今 上海交通大学转化医学研究院副院长。
1998年7月-迄今 国家人类基因组南方研究中心研究员、功能基因组部主任、省市共建国家重点实验室（基地）常务副主任、上海交通大学特聘教授、长江学者特聘教授
1991年7月-1995年8月 徐州医学院附属医院 助理研究员、主治医师、讲师
1986年7月-1988年8月 江苏徐州市第三医院内科 住院医师

 

人才奖项
1. 2016年高等学校科学研究优秀成果奖自然科学奖一等奖：乙型肝炎病毒感染相关肝癌的功能基因组研究（韩泽广、黄健、邓庆、郑大利）
2. 2016年 “万人计划”百千万工程领军人才
3. 2013年国家自然科学奖二等奖：日本血吸虫寄生和致病分子基础的系统生物学研究 (韩泽广、胡薇、刘锋、王升跃、冯正)
4. 2013年华夏医学科技奖:肝炎病毒感染相关肝病疾病进展的基础和临床 (谢青、韩泽广、项晓刚、黄健、王晖、邓庆、蔡伟、桂红莲 、林兰意、石翠翠、赵钢德、周惠娟)
5. 2012年上海市自然科学奖一等奖: 日本血吸虫生物特征的系统生物学研究（韩泽广、王升跃、刘锋、胡薇、冯正）
6. 2011年度上海医学科技奖一等奖：肝炎病毒感染相关肝病疾病进展的基础和临床（谢青、韩泽广、王晖、项晓刚、蔡伟、桂红莲、林兰意、石翠翠、赵钢德、周慧娟）
7. 2010年第三届“谈家桢生命科学奖” 生命科学创新奖
8. 2010年度高等学校科学研究优秀成果奖: 自然科学奖一等奖： 日本血吸虫基因组注释与寄生性适应研究的数据挖掘 （周雁,韩泽广,王升跃,钟扬,窦同海,赵国屏,顾坚磊）
9. 2009年度国家教育部长江学者特聘教授（上海交通大学）
10. 2009年“第十届上海市科技精英”提名奖
11. 2007年上海市自然科学奖二等奖: 乙型肝炎病毒相关肝癌的功能基因组学研究 （韩泽广、黄健、张新、王志勤）
12. 2006年 “新世纪百千万人才工程”国家级人选
13. 2004年国家自然科学奖二等奖：人类造血和内分泌相关细胞/组织基因表达谱和新基因识别研究 （陈竺、宋怀东、陈家伦、张庆华、韩泽广）
14. 2004年上海市科学进步奖二等奖：日本血吸虫功能基因组及其应用研究 （韩泽广、冯正、胡薇、王志勤、沈大康）
15. 2004年获得上海市优秀学科带头人计划项目
16. 2004年度国家杰出青年科学基金
17. 2003年获得国务院特殊津贴
18. 2003年上海市科学进步一等奖：造血相关基因表达谱、新基因克隆和染色体定位图谱的建立和研究 （陈竺、张庆华、韩泽广、傅刚、陈赛娟）
19. 2003年上海市科学进步二等奖：下丘脑-垂体-肾上腺轴组织基因表达谱的研究及新基因的全长cDNA克隆 （胡仁明、韩泽广、宋怀东、黄秋花、陈家伦）
20. 2000年发表在JBC杂志的文章《造血组织表达的krüppel样锌指基因结构和功能研究》（第一作者）获得全国优秀博士学位论文；此后受相关基金资助。

 

学会兼职与审稿人
中国医药生物技术协会基因检测技术分会 副主任委员
中国抗癌协会肿瘤精准治疗专业委员会 常务委员
上海市生物化学与分子生物学学会 理事
Advance in Preventive Medicine 执行主编
BMC Bioinformatics (Associate Editors)编辑
The scientific world journal编辑

1） 肿瘤（肝癌）发病机制研究：从遗传和表观遗传、细胞信号通路及代谢等方面研究与肝癌相关的重要基因的功能及其调节肿瘤发生和发展的分子机制；研究肿瘤相关重要基因突变的作用和机制；基于对肿瘤发生发展机制的研究，针对特定的靶点，应用新策略开发新疗法。
2） 功能基因组学相关技术研究和开发：目前集中进行单细胞分析及其数据分析的算法及软件研发。

发表论文130余篇，部分文章如下：

1. Hao J, Cao W, Huang J, Zou X, Han ZG. Optimal Gene Filtering for Single-Cell data (OGFSC) - a gene filtering algorithm for single-cell RNA-seq data. Bioinformatics. 2018 Dec 10. doi: 10.1093
2. Yuan Y, Shi Y, Su X, Zou X, Luo Q, Feng DD, Cai W, Han ZG. Cancer type prediction based on copy number aberration and chromatin 3D structure with convolutional neural networks. BMC Genomics. 2018 Aug 13;19(Suppl 6):565.
3. Huang LY, Zhao J, Chen H, Wan L, Inuzuka H, Guo J, Fu X, Zhai Y, Lu Z, Wang X, Han ZG, Sun Y, Wei W. SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis. Nat Commun. 2018 Sep 3;9(1):3569.
4. Huang LY, Wang X, Cui XF, Li H, Zhao J, Wu CC, Min L, Zhou Z, Wan L, Wang YP, Zhang C, Gao WQ, Sun Y, Han ZG. IRTKS is correlated with progression and survival time of patients with gastric cancer. Gut. 2018 Aug;67(8):1400-1409
5. Yuan Y, Shi Y, Su X, Zou X, Luo Q, Feng DD, Cai W, Han ZG. Cancer type prediction based on copy number aberration and chromatin 3D structure with convolutional neural networks. BMC Genomics. 2018 Aug 13;19(Suppl 6):565.
6. Su X, Shi Y, Zou X, Lu ZN, Xie G, Yang JYH, Wu CC, Cui XF, He KY, Luo Q, Qu YL, Wang N, Wang L, Han ZG. Single-cell RNA-Seq analysis reveals dynamic trajectories during mouse liver development. BMC Genomics. 2017 Dec 4;18(1):946.
7. Cheng S, Wang L, Deng CH, Du SC, Han ZG. ARID1A represses hepatocellular carcinoma cell proliferation and migration through lncRNA MVIH. Biochem Biophys Res Commun. 2017 Sep 9;491(1):178-182.
8. Xia P, Liu J, Wang S, Ye B, Du Y, Xiong Z, Han ZG, Tong L, Fan Z. WASH maintains NKp46+ ILC3 cells by promoting AHR expression. Nat Commun. 2017 Jun 7;8:15685.
9. Dai YJ, Wang YY, Huang JY, Xia L, Shi XD, Xu J, Lu J, Su XB, Yang Y, Zhang WN, Wang PP, Wu SF, Huang T, Mi JQ, Han ZG, Chen Z, Chen SJ. Conditional knockin of Dnmt3a R878H initiates acute myeloid leukemia with mTOR pathway involvement. Proc Natl Acad Sci U S A. 2017 May 16;114(20):5237-5242
10. Sagner M, McNeil A, Puska P, Auffray C, Price ND, Hood L, Lavie CJ, Han ZG, Chen Z, Brahmachari SK, McEwen BS, Soares MB, Balling R, Epel E, Arena R. The P4 Health Spectrum - A Predictive, Preventive, Personalized and Participatory Continuum for Promoting Healthspan. Prog Cardiovasc Dis. 2017 Mar - Apr;59(5):506-521
11. Cao W, Liu JN, Liu Z, Wang X, Han ZG, Ji T, Chen WT, Zou X. A three-lncRNA signature derived from the Atlas of ncRNA in cancer (TANRIC) database predicts the survival of patients with head and neck squamous cell carcinoma. Oral Oncol. 2017 Feb;65:94-101.
12. Wang X, Cao W, Zhang J, Yan M, Xu Q, Wu X, Wan L, Zhang Z, Zhang C, Qin X, Xiao M, Ye D, Liu Y, Han Z, Wang S, Mao L, Wei W, Chen W. A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination. EMBO J. 2017 May 2;36(9):1243-1260
13. Chen J, Fu Y, Day DS, Sun Y, Wang S, Liang X, Gu F, Zhang F, Stevens SM, Zhou P, Li K, Zhang Y, Lin RZ, Smith LEH, Zhang J, Sun K, Melero-Martin JM, Han Z, Park PJ, Zhang B, Pu WT. VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis. Nat Commun. 2017 Aug 29;8(1):383
14. Shi Y, Su XB, He KY, Wu BH, Zhang BY, Han ZG. Chromatin accessibility contributes to simultaneous mutations of cancer genes. Sci Rep. 2016 Oct 20;6:35270.
15. Cai CM, Xiao X, Wu BH, Wei BF, Han ZG. Targeting endogenous DLK1 exerts antitumor effect on hepatocellular carcinoma through initiating cell differentiation. Oncotarget. 2016 Nov 1;7(44):71466-71476.
16. Yin M, Liu X, Xu B, Huang J, Zheng Q, Yang Z, Feng Z, Han ZG, Hu W. Genetic variation between Schistosoma japonicum lineages from lake and mountainous regions in China revealed by resequencing whole genomes. Acta Trop. 2016 Sep;161:79-85.
17. Wu BH, Chen H, Cai CM, Fang JZ, Wu CC, Huang LY, Wang L, Han ZG. Epigenetic silencing of JMJD5 promotes the proliferation of hepatocellular carcinoma cells by down-regulating the transcription of CDKN1A. Oncotarget. 2016 Feb 9;7(6):6847-63
18. Wang X, Zhang Y, Han ZG, He KY. Malignancy of Cancers and Synthetic Lethal Interactions Associated With Mutations of Cancer Driver Genes. Medicine (Baltimore). 2016 Feb;95(8):e2697
19. Yuan Y, Shi Y, Li C, Kim J, Cai W, Han Z, Feng DD. DeepGene: an advanced cancer type classifier based on deep learning and somatic point mutations. BMC Bioinformatics. 2016 Dec 23;17(Suppl 17):476.
20. Fang JZ, Li C, Liu XY, Hu TT, Fan ZS, Han ZG. Hepatocyte-Specific Arid1a Deficiency Initiates Mouse Steatohepatitis and Hepatocellular Carcinoma. PLoS One. 2015 Nov 16;10(11):e0143042.
21. Hu T, Yang H, Han ZG. PDZRN4 acts as a suppressor of cell proliferation in human liver cancer cell lines. Cell Biochem Funct. 2015 Oct;33(7):443-9
22. Xia P, Wang S, Xiong Z, Ye B, Huang LY, Han ZG, Fan Z. IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation. Nat Commun. 2015 Sep 8;6:8132. doi: 10.1038/ncomms9132
23. Zhang ZZ, Huang J, Wang YP, Cai B, Han ZG. NOXIN as a cofactor of DNA polymerase-primase complex could promote hepatocellular carcinoma. Int J Cancer. 2015 Aug 15;137(4):765-75.
24. Liao Y, Ling J, Zhang G, Liu F, Tao S, Han Z, Chen S, Chen Z, Le H. Cordycepin induces cell cycle arrest and apoptosis by inducing DNA damage and up-regulation of p53 in Leukemia cells. Cell Cycle. 2015;14(5):761-71
25. Han ZG. Mutational landscape of hepatoblastoma goes beyond Wnt-β-catenin pathway. Hepatology. 2014; 60(5):1476-8.(editorial)
26. Wang Q, Zhai YY, Dai JH, Li KY, Deng Q, Han ZG. SAMD9L Inactivation Promotes Cell Proliferation via Facilitating G1-S Transition in Hepatitis B Virus-associated Hepatocellular Carcinoma. Int J Biol Sci. 2014 Jul 17;10(8):807-16
27. Deng Q, Li KY, Chen H, Dai JH, Zhai YY, Wang Q, Li N, Wang YP, Han ZG. RNA interference against cancer/testis genes identifies DUSP21 as a potential therapeutic target in human hepatocellular carcinoma. Hepatology. 2014 Feb;59(2):518-30
28. Stefanska B, Cheishvili D, Suderman M, Arakelian A, Huang J, Hallett M, Han ZG, Al-Mahtab M, Akbar SM, Khan WA, Raqib R, Tanvir I, Khan HA, Rabbani SA, Szyf M. Genome-wide study of hypomethylated and induced genes in patients with liver cancer unravels novel anticancer targets. Clin Cancer Res. 2014 Jun 15;20(12):3118-32
29. Wang D, Han S, Peng R, Jiao C, Wang X, Han Z, Li X. DUSP28 contributes to human hepatocellular carcinoma via regulation of the p38 MAPK signaling. Int J Oncol. 2014 Dec;45(6):2596-604
30. Zhang H, Tian Y, Shen J, Wang Y, Xu Y, Wang Y, Han Z, Li X. Upregulation of the putative oncogene COTE1 contributes to human hepatocarcinogenesis through modulation of WWOX signaling. Int J Oncol. 2014 Aug;45(2):719-31
31. Huang LY, Wang YP, Wei BF, Yang J, Wang JQ, Wu BH, Zhang ZZ, Hou YY, Sun WM, Hu RM, Ning G, Han ZG. Deficiency of IRTKS as an adaptor of insulin receptor leads to insulin resistance. Cell Res. 2013 Nov;23(11):1310-21
32. Tao HC, Wang HX, Dai M, Gu CY, Wang Q, Han ZG, Cai B. Targeting SHCBP1 Inhibits Cell Proliferation in Human Hepatocellular Carcinoma Cells. Asian Pac J Cancer Prev. 2013;14(10):5645-50.
33. Wang YP, Huang LY, Sun WM, Zhang ZZ, Fang JZ, Wei BF, Wu BH, Han ZG. Insulin receptor tyrosine kinase substrate activates EGFR/ERK signalling pathway and promotes cell proliferation of hepatocellular carcinoma. Cancer Lett. 2013 Aug 28;337(1):96-106
34. Cheng N, Li Y, Han ZG. Argonaute2 promotes tumor metastasis by way of up-regulating focal adhesion kinase expression in hepatocellular carcinoma. Hepatology 2013 May; 57(5):1906-1918
35. Li Y, Zhou B, Dai J, Liu R, Han ZG. Aberrant upregulation of LRRC1 contributes to human hepatocellular carcinoma. Mol Biol Rep. 2013 Jul;40(7):4543-51
36. Zhou B, Li Y, Deng Q, Wang H, Wang Y, Cai B, Han ZG. SRPK1 contributes to malignancy of hepatocellular carcinoma through a possible mechanism involving PI3K/Akt. Mol Cell Biochem. 2013 Jul;379(1-2):191-199
37. Liu RF, Xu X, Huang J, Fei QL, Chen F, Li YD, Han ZG. Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2. Cancer Lett. 2013 Feb 28;329(2):164-73
38. Stefanska B, Bouzelmat A, Huang J, Suderman M, Hallett M, Han ZG, Al-Mahtab M, Akbar SM, Khan WA, Raqib R, Szyf M. Discovery and validation of DNA hypomethylation biomarkers for liver cancer using HRM-specific probes. PLoS One. 2013 Aug 7;8(8):e68439.
39. Zhang J, Sun Q, Zhang Z, Ge S, Han ZG, Chen WT. Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop. Oncogene. 2013 Jan 3;32(1):61-9.
40. Deng R, Wang X, Liu Y, Yan M, Hanada S, Xu Q, Zhang J, Han Z, Chen W, Zhang P. A new gamboge derivative compound 2 inhibits cancer stem-like cells via suppressing EGFR tyrosine phosphorylation in head and neck squamous cell carcinoma. J Cell Mol Med. 2013 Nov;17(11):1422-33.
41. Tian Y, Huang C, Zhang H, Ni Q, Han S, Wang D, Han Z, Li X. CDCA7L promotes hepatocellular carcinoma progression by regulating the cell cycle. Int J Oncol. 2013 Dec;43(6):2082-90
42. Huang J, Deng Q, Wang Q, Li KY, Dai JH, Li N, Zhu ZD, Zhou B, Liu XY, Liu RF, Fei QL, Chen H, Cai B, Zhou B, Xiao HS, Qin LX, Han ZG. Exome sequencing of hepatitis B virus-associated hepatocellular carcinoma. Nat Genet. 2012 Aug 26;44(10):1117-1121 (Commentary by Zhang Z: Genomic landscape of liver cancer. Nat Genet. 2012; 44(10):1075-7)
43. Han ZG. Functional Genomic Studies: Insights into the Pathogenesis of Liver Cancer. Annu Rev Genomics Hum Genet. 2012 Sep 22;13:171-205. (invited review)
44. Wang H, Wu K, Sun Y, Li Y, Wu M, Qiao Q, Wei Y, Han ZG, Cai B. STC2 is upregulated in hepatocellular carcinoma and promotes cell proliferation and migration in vitro. BMB Rep. 2012 Nov;45(11):629-34
45. Wei YJ, Hu QQ, Gu CY, Wang YP, Han ZG, Cai B. Up-regulation of NICE-3 as a Novel EDC Gene Could Contribute to Human Hepatocellular Carcinoma. Asian Pac J Cancer Prev. 2012;13(9):4363-8.
46. Wang H, Li Y, Wang Y, Han ZG, Cai B. C9orf100, a new member of the Dbl-family guanine nucleotide exchange factors, promotes cell proliferation and migration in hepatocellular carcinoma. Mol Med Report. 2012 May;5(5):1169-74
47. Xu X, Liu RF, Zhang X, Huang LY, Chen F, Fei QL, Han ZG. DLK1 as a potential target against cancer stem/progenitor cells of hepatocellular carcinoma. Mol Cancer Ther. 2012 Mar;11(3):629-38
48. Yan B, Zhang ZZ, Huang LY, Shen HL, Han ZG. OIT3 deficiency impairs uric acid reabsorption in renal tubule. FEBS Lett. 2012 Mar 23;586(6):760-5
49. Zhang H, Huang CJ, Tian Y, Wang YP, Han ZG, Li XC. Ectopic overexpression of COTE1 promotes cellular invasion of hepatocellular carcinoma. Asian Pac J Cancer Prev. 2012;13(11):5799-804
50. Yang XH, Feng ZE, Yan M, Hanada S, Zuo H, Yang CZ, Han ZG, Guo W, Chen WT, Zhang P. XIAP is a predictor of cisplatin-based chemotherapy response and prognosis for patients with advanced head and neck cancer. PLoS One. 2012;7(3):e31601
51. Stefanska B, Huang J, Bhattacharyya B, Suderman M, Hallett M, Han ZG, Szyf M. Definition of the landscape of promoter DNA hypomethylation in liver cancer. Cancer Res. 2011 Sep 1;71(17):5891-903. (co-communicating author)
52. Xu X, Liu RF, Wan BB, Xing WM, Huang J, Han ZG. Expression of a novel gene FAM43B repressing cell proliferation is regulated by DNA methylation in hepatocellular carcinoma cell lines. Mol Cell Biochem. 2011; 354(1-2):11-20.
53. Wang KS, Chen G, Shen HL, Li TT, Chen F, Wang QW, Wang ZQ, Han ZG, Zhang X. Insulin receptor tyrosine kinase substrate enhances low levels of MDM2-mediated p53 ubiquitination. PLoS One. 2011;6(8):e23571
54. Fu Y, Huang J, Wang KS, Zhang X, Han ZG. RNA interference targeting CITRON can significantly inhibit the proliferation of hepatocellular carcinoma cells. Mol Biol Rep. 2011 Feb;38(2):693-702
55. Han ZG. Epigenetic analysis in the search for tumor suppressor genes. Epigenomics. 2010; 2(4): 489-493 (Editorial)
56. Han ZG. Systems biomedical analysis of Schistosoma japonicum. Frontiers of Medicine in China. 2010; 4(2):157-165 (invited review)
57. Deng Q, Wang Q, Zong WY, Zheng DL, Wen YX, Wang KS, Teng XM, Zhang X, Huang J, Han ZG. E2F8 Contributes to Human Hepatocellular Carcinoma via Regulating Cell Proliferation. Cancer Res. 2010 Jan 15;70(2):782-91
58. Huang J, Zheng DL, Qin FS, Cheng N, Chen H, Wan BB, Wang YP, Xiao HS, Han ZG. Genetic and epigenetic silencing of SCARA5 may contribute to hepatocellular carcinoma by activating FAK signaling. J Clin Invest. 2010 Jan;120(1):223-241(highlight in this issue: Epigenetic silencing of an HCC suppressor)(Nature China Research Highlights: Medical genetics: Silence of the gene)
59. Cao W, Zhang ZY, Xu Q, Sun Q, Yan M, Zhang J, Zhang P, Han ZG, Chen WT. Epigenetic silencing of MAL, a putative tumor suppressor gene, can contribute to human epithelium cell carcinoma. Mol Cancer. 2010 Nov 22;9:296
60. Yu Y, Ping J, Chen H, Jiao L, Zheng S, Han ZG, Hao P, Huang J. A comparative analysis of liver transcriptome suggests divergent liver function among human, mouse and rat. Genomics. 2010 Nov;96(5):281-9
61. Chuan J, Feng Z, Brindley PJ, McManus DP, Han Z, Jianxin P, Hu W. Our wormy world genomics, proteomics and transcriptomics in East and southeast Asia. Adv Parasitol. 2010;73:327-71.
62. Huang J, Pei Hao, Hui Chen, Wei Hu, Qing Yan, Feng Liu, ZG Han. Genome-wide identification of Schistosoma japonicum microRNAs using a deep sequencing approach. PLoS One 2009; 4(12): e8206
63. Wang ZQ, Xing WM, Fan HH, Wang KS, Zhang HK, Wang QW, Qi J, Yang HM, Yang J, Ren YN, Cui SJ, Zhang X, Liu F, Lin DH, Wang WH, Hoffmann MK, Han ZG. The novel lipopolysaccharide-binding protein CRISPLD2 is a critical serum protein to regulate endotoxin function. J Immunol. 2009 Nov 15;183(10):6646-56
64. Han ZG, Brindley PJ, Wang SY, Chen Z. Schistosoma genomics: new perspectives on schistosome biology and host-parasite interaction. Annu Rev Genomics Hum Genet. 2009;10:211-240 (invited review)
65. The Schistosoma japonicum Genome Sequencing and Functional Analysis Consortium. The Schistosoma japonicum genome reveals features of host-parasite interplay. Nature, 2009; 460, 345-351 (Cover) (Nature China Research Highlights) (as one of corresponding authors)
66. Liu F, Cui SJ, Hu W, Feng Z, Wang ZQ, Han ZG. Excretory/secretory proteome of the adult developmental stage of human blood fluke, Schistosoma japonicum. Mol Cell Proteomics. 2009; 8(6):1236-1251
67. Ma Y, Qi X, Du J, Song S, Feng D, Qi J, Zhu Z, Zhang X, Xiao H, Han Z, Hao X. Identification of candidate genes for human pituitary development by EST analysis. BMC Genomics. 2009 Mar 15;10:109.
68. Li T, Huang J, Jiang Y, Zeng Y, He F, Zhang MQ, Han Z, Zhang X. Multi-stage analysis of gene expression and transcription regulation in C57/B6 mouse liver development. Genomics. 2009 Mar;93(3):235-42
69. Han Z. Recent progress in genomic research of liver cancer. Sci China C Life Sci. 2009 Jan;52(1):24-30
70. Wan B, Wang XR, Zhou YB, Zhang X, Huo K, Han ZG. C12ORF39, a novel secreted protein with a typical amidation processing signal. Biosci Rep. 2009 Sep 17;30(1):1-10
71. Shen HL, Xu ZG, Huang LY, Liu D, Lin DH, Cao JB, Zhang X, Wang ZQ, Wang WH, Yang PY, Han ZG. Liver-specific ZP domain-containing protein (LZP) as a new partner of Tamm-Horsfall protein harbors on renal tubules. Mol Cell Biochem. 2009 Jan;321(1-2):73-83
72. Zheng DL, Zhang L, Cheng N, Xu X, Deng Q, Teng XM, Wang KS, Zhang X, Huang J, Han ZG. Epigenetic modification induced by hepatitis B virus X protein via interaction with de novo DNA methyltransferase DNMT3A. J Hepatol. 2009 Feb;50(2):377-387. Epub 2008 Nov 28 (Editorial for comment on this paper: Herceg Z, Paliwal A. HBV protein as a double-barrel shot-gun targets epigenetic landscape in liver cancer. J Hepatol. 2009 Feb;50(2):252-255
73. Huang J, Lin Y, Li L, Qing D, Teng XM, Zhang YL, Hu X, Hu Y, Yang P, Han ZG. ARHI, as a novel suppressor of cell growth and downregulated in human hepatocellular carcinoma, could contribute to hepatocarcinogenesis. Mol Carcinog. 2009; 48(2):130-140
74. Guo Y, Zhang X, Huang J, Zeng Y, Liu W, Geng C, Li KW, Yang D, Wu S, Wei H, Han Z, Qian X, Jiang Y, He F. Relationships between hematopoiesis and hepatogenesis in the midtrimester fetal liver characterized by dynamic transcriptomic and proteomic profiles. PLoS One. 2009 Oct 28;4(10):e7641.
75. Lin DH, Yue P, Pan CY, Sun P, Zhang X, Han Z, Roos M, Caplan M, Giebisch G, Wang WH. POSH stimulates the ubiquitination and the clathrin-independent endocytosis of ROMK1 channels. J Biol Chem. 2009 Oct 23;284(43):29614-24
76. Wan B, Zhou YB, Zhang X, Zhu H, Huo K, Han ZG. hOLFML1, a novel secreted glycoprotein, enhances the proliferation of human cancer cell lines in vitro. FEBS Lett. 2008 Sep 22;582(21-22):3185-3192
77. Liu F, Chen P, Cui SJ, Wang ZQ, Han ZG.. SjTPdb: integrated transcriptome and proteome database and analysis platform for Schistosoma japonicum. BMC Genomics. 2008 Jun 26;9:304.
78. Zhou YB, Cao JB, Wan BB, Wang XR, Ding GH, Zhu H, Yang HM, Wang KS, Zhang X, Han ZG. hBolA, novel non-classical secreted proteins, belonging to different BolA family with functional divergence. Mol Cell Biochem. 2008; 317(1-2): 61-68
79. Deng X, Chen YX, Zhang X, Zhang JP, Yin C, Yue HY, Lin Y, Han ZG, Xie WF. Hepatic stellate cells modulate the differentiation of bone marrow mesenchymal stem cells into hepatocyte-like cells. J Cell Physiol. 2008 Oct;217(1):138-44
80. Chen C, Huang C, Chen S, Liang J, Lin W, Ke G, Zhang H, Wang B, Huang J, Han Z, Ma L, Huo K, Yang X, Yang P, He F, Tao T. Subunit–subunit interactions in the human 26S proteasome. Proteomics. 2008 Feb;8(3):508-20
81. Peng H, Song K, Huang C, Ye S, Song H, Hu W, Han Z, McManus DP, Zhao G, Zhang Q. Expression, immunolocalization and serodiagnostic value of a myophilin-like protein from Schistosoma japonicum. Exp Parasitol. 2008 May;119(1):117-24
82. Huang J, Zhang YL, Teng XM, Lin Y, Zheng DL, Yang PY, Han ZG. Down-regulation of SFRP1 as a putative tumor suppressor gene can contribute to human hepatocellular carcinoma. BMC Cancer 2007, 7:126
83. Huang J, Hao P, Zhang YL, Deng FX, Deng Q, Hong Y, Wang XW, Wang Y, Li TT, Zhang XG, Li YX, Yang PY, Wang HY, Han ZG. Discovering multiple transcripts of human hepatocytes using massively parallel signature sequencing (MPSS). BMC Genomics. 2007;8(1):207
84. Zhang X, Lin DH, Jin Y, Wang KS, Zhang Y, Babilonia E, Wang Z, Wang Z, Giebisch G, Han ZG, Wang WH. Inhibitor of growth 4 (ING4) is up-regulated by a low K intake and suppresses renal outer medullary K channels (ROMK) by MAPK stimulation. Proc Natl Acad Sci U S A. 2007; 104(22):9517-9522.
85. Zhou YB, Cao JB, Yang HM, Zhu H, Xu ZG, Wang KS, Zhang X, Wang ZQ, Han ZG. hZG16, a novel human secreted protein expressed in liver, was down-regulated in hepatocellular carcinoma. Biochem Biophys Res Commun. 2007; 355(3):679-686
86. Huang J, Zhang X, Zhang M, Zhu JD, Zhang YL, Lin Y, Wang KS, Qi XF, Zhang Q, Liu GZ, Yu J, Cui Y, Yang PY, Wang ZQ, Han ZG. Up-regulation of DLK1 gene could contribute to human hepatocellular carcinoma. Carcinogenesis. 2007; 28(5):1094-1103
87. Liu F, Hu W, Cui SJ, Chi M, Fang CY, Wang ZQ, Yang PY, Han ZG. Insight into the host-parasite interplay by proteomic study of host proteins copurified with the human parasite, Schistosoma japonicum. Proteomics. 2007 Feb;7(3):450-462 [highlight/currents “Host proteins copurify with blood flukes”in Journal of Proteome Research 2007, 4(6):1239]
88. Pan Q, Zhang ZB, Zhang X, Shi J, Chen YX, Han ZG, Xie WF. Gene expression profile analysis of the spontaneous reversal of rat hepatic fibrosis by cDNA microarray. Dig Dis Sci. 2007 Oct;52(10):2591-600
89. Niu J, Xu Z, Li XN, Han Z. siRNA-mediated type 1 insulin-like growth factor receptor silencing induces chemosensitization of a human liver cancer cell line with mutant P53. Cell Biol Int. 2007 Feb;31(2):156-64
90. Shen Y, Xu Q, Han Z, Liu H, Zhou GB. Analysis of phenotype-genotype connection: the story of dissecting disease pathogenesis in genomic era in China, and beyond. Philos Trans R Soc Lond B Biol Sci. 2007 Jun 29;362(1482):1043-61.
91. Wang XR, Zhou YB, Liu F, Wang KS, Shen Y, Liu JH, Han ZG. A novel lately evolutionary gene C19orf24 encoded a nonclassical secreted protein. Cell Mol Biol Lett. 2006;11(2):161-70.
92. Huang J, Sheng HH, Shen T, Hu YJ, Xiao HS, Zhang Q, Zhang QH, Han ZG. Correlation between genomic DNA copy number alterations and transcriptional expression in hepatitis B virus-associated hepatocellular carcinoma. FEBS Lett. 2006 Jun 26;580(15):3571-81
93. Qi J, Zhang X, Zhang HK, Yang HM, Zhou YB, Han ZG. ZBTB34, a novel Human BTB/POZ Zinc Finger Protein, is a Potential Transcriptional Repressor. Mol Cell Biochem. Mol Cell Biochem. 2006 Oct;290(1-2):159-67.
94. Liu F, Lu J, Hu W, Wang SY, Cui SJ, Chi M, Yan Q, Wang XR, Song HD, Xu XN, Wang JJ, Zhang XL, Zhang X, Wang ZQ, Xue CL, Brindley PJ, McManus DP, Yang PY, Feng Z, Chen Z, Han ZG. New perspectives on the parasite-host interplay by comparative transcriptomic and proteomic analyses of the human blood fluke, Schistosoma japonicum. PLoS Pathog. 2006 Apr;2(4):e29
95. Liu F, Lu J, Fan HH, Wang ZQ, Cui SJ, Zhang GA, Chi M, Zhang X, Yang PY, Chen Z, Han ZG. Insights into human CD34-positive hematopoietic stem/progenitor cells through a systematical proteomic survey coupled with transcriptome analysis. Proteomics. 2006 May;6(9):2673-92.
96. Qiang H, Lin Y, Zhang X, Zeng X, Shi J, Chen YX, Yang MF, Han ZG, Xie WF. Differential expression genes analyzed by cDNA array in the regulation of rat hepatic fibrogenesis. Liver Int. 2006 Nov;26(9):1126-37
97. Qin XY, Shen KT, Song LJ, Zhang X, Han ZG. Regulated production of mature insulin in rat hepatoma cells: insulin production is up-regulated by dexamethasone and down-regulated by insulin. Acta Biochim Biophys Sin (Shanghai). 2006 Feb;38(2):89-94
98. Wang L, Yang Z, Li Y, Yu F, Brindley PJ, McManus DP, Wei D, Han Z, Feng Z, Li Y, Hu W. Reconstruction and in silico analysis of the MAPK signaling pathways in the human blood fluke, Schistosoma japonicum. FEBS Lett. 2006 Jun 26;580(15):3677-86.
99. Zhang X, Wang KS, Wang ZQ, Xu LS, Wang QW, Chen F, Wei DZ, Han ZG. Nuclear localization signal of ING4 play a key role in its binding to p53. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1032-8
100. Ma YY, Qi XF, Song SJ, Zhao ZY, Zhu ZD, Qi J, Zhang X, Xiao HS, Teng Y, Han ZG. cDNA Microarray Reveals Signaling Pathways Involved in Hormones Expression of Human Pituitary. Gen Comp Endocrinol. 2005 Sep 1;143(2):184-192.
101. Zeng LC, Han ZG, Ma WJ. Elucidation of subfamily segregation and intramolecular coevolution of the olfactomedin-like proteins by comprehensive phylogenetic analysis and gene expression pattern assessment. FEBS Lett. 2005 Oct 24;579(25):5443-53.
102. Zhou YB, Liu F, Zhu ZD, Zhu H, Zhang X, Wang ZQ, Liu JH, Han ZG. N-glycosylation is required for efficient secretion of a novel human secreted glycoprotein, hPAP21. FEBS Lett. 2004 Oct 22;576(3):401-7
103. Zhang X, Xu LS, Wang ZQ, Wang KS, Li N, Cheng ZH, Huang SZ, Wei DZ, Han ZG. ING4 induces G2/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells. FEBS Lett. 2004 Jul 16;570(1-3):7-12.
104. Xu ZG, Du JJ, Cui SJ, Wang ZQ, Huo KK, Li YY, Han ZG. Identification of LZP gene from Mus musculus and Rattus norvegicus coding for a novel liver-specific ZP domain-containing secretory protein. DNA SEQUENCE 2004, 15 (2): 81-87
105. Hu W, Brindley PJ, McManus DP, Feng Z, Han ZG. Schistosome transcriptomes: new insights into the parasite and schistosomiasis. Trends Mol Med. 2004, 10: 217-225.
106. McManus DP, Hu W, Brindley PJ, Feng Z, Han ZG. Schistosome transcriptome analysis at the cutting edge. Trends Parasitol. 2004 Jul;20(7):301-4.
107. Zeng LC, Liu F, Zhang X, Zhu ZD, Wang ZQ, Han ZG, Ma WJ. hOLF44, a secreted glycoprotein with distinct expression pattern, belongs to an uncharacterized olfactomedin-like subfamily newly identified by phylogenetic analysis. FEBS Lett. 2004 Jul 30;571(1-3):74-80
108. Imanishi T, …Han ZG, …Sugano S. Integrative annotation of 21,037 human genes validated by full-length cDNA clones. PLoS Biol. 2004 Jun;2(6):e162
109. Han ZG, Zhao GP, Chen Z. Transcriptome study in China. C R Biol. 2003 Oct-Nov;326(10-11):949-57 (review)
110. Liu F, Rong YP, Zeng LC, Zhang X, Han ZG. Isolation and characterization of a novel human thioredoxin-like gene hTLP19 encoding a secretory protein. Gene. 2003；315:71-78.
111. Hu W, Yan Q, Shen DK, Liu F, Zhu ZD, Song HD, Xu XR, Wang ZJ, Rong YP, Zeng LC, Wu J, Zhang X, Wang JJ, Xu XN, Wang SY, Fu G, Zhang XL, Wang ZQ, Brindley PJ, McManus DP, Xue CL, Feng Z, Chen Z, Han ZG. Evolutionary and biomedical implications of a Schistosoma japonicum complementary DNA resource. Nat Genet. 2003; 35(2):139-147.
112. Xu ZG, Du JJ, Zhang X, Cheng ZH, Ma ZZ, Xiao HS, Yu L, Wang ZQ, Li YY, Huo KK, Han ZG. A novel liver-specific zona pellucida domain containing protein that is expressed rarely in hepatocellular carcinoma. Hepatology. 2003; 38:735-744.
113. Du JJ, Dou KF, Peng SY, Qian BZ, Xiao HS, Liu F, Wang WZ, Guan WX, Gao ZQ, Liu YB, Han ZG. Expression of NGF family and their receptors in gastric carcinoma: A cDNA microarray study. World J Gastroenterol. 2003 Jul;9(7):1431-1434.
114. Zhang X, Huang QH, Han ZG. Generation of cDNA libraries for profiling gene expression of given tissues or cells. Methods Mol Biol 2003;221:179-195
115. Yang YS, Song HD, Peng YD, Huang QH, Li RY, Zhu ZD, Hu RM, Han ZG, Chen JL. The gene expression profiling of sporadic pheochromocytoma and novel full-length cDNAs cloning. Endocr Relat Cancer. 2003 Dec;10(4):621-7
116. Yang YS, Song HD, Li RY, Zhou LB, Zhu ZD, Hu RM, Han ZG, Chen JL. The gene expression profiling of human visceral adipose tissue and its secretory functions. Biochem Biophys Res Commun. 2003 Jan 24;300(4):839-46
117. Scheper GC, Parra JL, Wilson M, Van Kollenburg B, Vertegaal AC, Han ZG, Proud CG. The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization. Mol Cell Biol. 2003 Aug;23(16):5692-705
118. Xiao HS, Huang QH, Zhang FX, Bao L, Lu YJ, Guo C, Yang L, Huang WJ, Fu G, Xu SH, Cheng XP, Yan Q, Zhu ZD, Zhang X, Chen Z, Han ZG, Zhang X. Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8360-8365.
119. Yang YS, Song HD, Shi WJ, Hu RM, Han ZG, Chen JL. Chromosome localization analysis of genes strongly expressed in human visceral adipose tissue. Endocrine. 2002 Jun;18(1):57-66
120. Qin XY, Shen KT, Zhang X, Cheng ZH, Xu XR, Han ZG. Establishment of an artificial beta-cell line expressing insulin under the control of doxycycline. World J Gastroenterol. 2002 Apr;8(2):367-70
121. Xu XR, Huang J, Xu ZG, Qian BZ, Zhu ZD, Yan Q, Cai T, Zhang X, Xiao HS, Qu J, Liu F, Huang QH, Cheng ZH, Li NG, Du JJ, Hu W, Shen KT, Lu G, Fu G, Zhong M, Xu SH, Gu WY, Huang W, Zhao XT, Hu GX, Gu JR, Chen Z, Han ZG. Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. Proc. Natl. Acad. Sci. USA 2001; 98: 15089-15094
122. Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. Proc. Natl. Acad. Sci. USA 2000; 97: 9543-9548 (as one of corresponding authors)
123. Gu J, Zhang QH, Huang QH, Ren SX, Wu XY, Ye M, Huang CH, Fu G, Zhou J, Niu C, Han ZG, Chen SJ, Chen Z. Gene expression in CD34(+) cells from normal bone marrow and leukemic origins. Hematol J. 2000;1(3):206-17
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125. Han ZG, Zhang QH, Ye M, et al. Molecular cloning of six novel krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. The Journal of Biological Chemistry 1999; 274: 35741-35748
126. Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8175-80
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申请中专利：
1. OGFSC-降低单细胞转录组数据中技术噪声的新算法 CN201810828849.6 郝洁, 邹欣, 韩泽广
2. 检测人血清DLK1蛋白的ELISA试剂盒及其用途 201810027820.9 韩泽广，翟杨杨
3. 针对肝癌相关抗原DLK1为靶点的CAR-T构建方法 201810042639.4 韩泽广，翟杨杨
4. 肝癌基因检测方法，检测试剂盒及其应用 201410499216.7 韩泽广，胡涛涛
5. IRTKS基因肝脏特异性剔除的小鼠模型及构建与应用 201611089590.5 韩泽广，黄丽钰，吴崇超
6. IRTKS基因剔除的小鼠模型及其构建方法与应用 201310267704.0 韩泽广，黄丽钰

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